GREMLIN Database
TRL - TRL-like protein family
PFAM: PF13146 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (75)
Sequences: 3751 (2842)
Seq/√Len: 328.1
META: 0.951

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_C71_T3.7701.00
42_E46_K3.1121.00
55_H75_Y2.9321.00
27_A39_A2.9061.00
45_A53_I2.0311.00
24_E71_T1.9531.00
38_D43_A1.9011.00
52_K77_E1.7651.00
28_T69_K1.7091.00
9_G58_Y1.6391.00
26_C69_K1.6371.00
24_E73_I1.5981.00
30_I36_T1.5461.00
24_E59_E1.5211.00
61_T69_K1.5171.00
6_D59_E1.4591.00
43_A47_N1.4431.00
59_E71_T1.3941.00
56_V74_V1.3881.00
41_I56_V1.3721.00
62_N68_A1.3601.00
58_Y70_Y1.3361.00
25_A44_A1.3201.00
19_G54_S1.3101.00
28_T36_T1.3061.00
8_K59_E1.3041.00
63_I67_Y1.2761.00
60_V68_A1.2551.00
15_S18_V1.2311.00
23_G44_A1.2151.00
60_V70_Y1.2111.00
54_S77_E1.1851.00
44_A48_G1.1621.00
29_S35_A1.1541.00
22_V75_Y1.1191.00
28_T67_Y1.1121.00
59_E73_I1.0851.00
43_A46_K1.0751.00
21_K50_I1.0531.00
20_S77_E1.0501.00
61_T67_Y1.0301.00
22_V73_I0.9861.00
21_K51_T0.9401.00
29_S68_A0.9161.00
14_T18_V0.9101.00
11_V58_Y0.9081.00
41_I53_I0.9061.00
40_S43_A0.8931.00
50_I53_I0.8911.00
45_A54_S0.8701.00
62_N65_G0.8441.00
42_E45_A0.8171.00
28_T61_T0.8081.00
14_T17_A0.8041.00
39_A72_T0.7831.00
58_Y72_T0.7731.00
6_D61_T0.7701.00
6_D36_T0.7581.00
9_G60_V0.7581.00
54_S75_Y0.7470.99
13_A16_N0.7460.99
21_K48_G0.7440.99
27_A37_G0.7310.99
41_I45_A0.7300.99
40_S57_D0.7220.99
21_K49_G0.7220.99
7_V60_V0.7220.99
50_I74_V0.7150.99
29_S37_G0.7130.99
19_G77_E0.7120.99
19_G55_H0.7020.99
29_S33_L0.6890.99
25_A72_T0.6860.99
12_A18_V0.6820.99
30_I67_Y0.6790.99
10_P13_A0.6790.99
53_I74_V0.6770.99
65_G68_A0.6750.99
39_A70_Y0.6500.98
27_A35_A0.6490.98
13_A17_A0.6440.98
25_A43_A0.6420.98
48_G74_V0.6320.98
25_A48_G0.6240.98
18_V54_S0.6230.98
33_L36_T0.6110.98
37_G67_Y0.6080.98
45_A52_K0.6050.98
23_G47_N0.6040.98
45_A48_G0.6020.97
17_A52_K0.6000.97
35_A39_A0.5990.97
12_A15_S0.5920.97
8_K73_I0.5850.97
25_A47_N0.5670.96
49_G53_I0.5670.96
40_S72_T0.5650.96
32_G68_A0.5630.96
10_P15_S0.5540.96
6_D69_K0.5520.96
63_I69_K0.5490.96
30_I34_V0.5470.96
8_K40_S0.5370.95
50_I54_S0.5240.94
44_A74_V0.5150.94
5_T62_N0.5140.94
12_A17_A0.5100.94
36_T61_T0.5040.93
48_G53_I0.5040.93
11_V16_N0.5030.93
35_A63_I0.5030.93
46_K51_T0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dfsA 2 0.7532 2.4 0.913 Contact Map
2v26A 1 0.7532 2.3 0.914 Contact Map
2xb0X 1 0.7792 2.3 0.914 Contact Map
1w7jA 2 0.7532 2 0.917 Contact Map
1g8xA 2 0.7532 2 0.917 Contact Map
1w9iA 1 0.7532 1.7 0.92 Contact Map
1m6bA 1 0.2078 1.6 0.921 Contact Map
4qbdA 1 0.7532 1.6 0.921 Contact Map
4akgA 2 0.987 1.6 0.921 Contact Map
1kk8A 1 0.7532 1.5 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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