AsmA_1 - PFAM28P - GREMLIN Contacts

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AsmA_1 - AsmA-like C-terminal region

PFAM:	PF13109	Sequences: DNITAQLKYKNGKIKFKKKNNKFTLKAKNFNDKFLNALLNFKGFKGGRLDFKGKGPDKNLKGKIKIKNGTIKDFKALNNILAFINTIPSLLTFSLPGLSGEGLPFKEGYIKFSLKDGILTIDDIYLDGPSIDILGKGYIDLKKKTIDLDLTLVPAKTLNKIIGKIPLVGYILLGKDGSISTSFKIKGPLDDPKVTTNLAKDILKAPLNIIKRTL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	214 (204)
Sequences:	1073 (822)
Seq/√Len:	57.5
META:	0.89

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
121_I	124_I	5.231	1.00
144_K	190_D	4.871	1.00
203_L	206_P	3.628	1.00
140_D	143_K	3.624	1.00
114_L	119_L	3.410	1.00
137_G	148_L	3.305	1.00
124_I	135_G	3.267	1.00
62_G	112_F	3.220	1.00
145_T	188_P	2.869	1.00
135_G	150_L	2.587	1.00
208_N	211_K	2.579	1.00
35_L	38_L	2.524	1.00
199_A	202_I	2.365	1.00
113_S	122_D	2.194	1.00
89_S	92_T	2.183	1.00
148_L	185_I	2.122	1.00
14_I	30_F	2.099	1.00
110_I	121_I	1.990	1.00
79_N	82_A	1.928	1.00
146_I	189_L	1.903	1.00
138_Y	147_D	1.874	1.00
117_G	142_K	1.862	1.00
74_F	78_N	1.803	0.99
58_K	146_I	1.767	0.99
210_I	213_T	1.758	0.99
132_D	156_K	1.750	0.99
111_K	123_D	1.749	0.99
200_K	207_L	1.742	0.99
118_I	140_D	1.700	0.99
208_N	213_T	1.700	0.99
173_L	179_I	1.699	0.99
80_I	194_V	1.696	0.99
27_A	30_F	1.680	0.99
205_A	209_I	1.646	0.99
188_P	191_D	1.638	0.99
77_L	131_I	1.616	0.99
198_L	206_P	1.564	0.98
13_K	17_K	1.559	0.98
93_F	96_P	1.548	0.98
205_A	208_N	1.539	0.98
11_N	15_K	1.504	0.98
144_K	188_P	1.472	0.98
106_K	127_D	1.466	0.97
69_G	75_K	1.416	0.97
90_L	93_F	1.411	0.97
79_N	97_G	1.401	0.97
151_T	180_S	1.381	0.96
78_N	82_A	1.381	0.96
71_I	78_N	1.372	0.96
75_K	78_N	1.357	0.96
10_K	33_K	1.357	0.96
201_D	206_P	1.347	0.96
11_N	17_K	1.338	0.96
34_F	38_L	1.327	0.95
102_G	128_G	1.324	0.95
197_N	201_D	1.311	0.95
126_L	139_I	1.310	0.95
156_K	159_N	1.306	0.95
119_L	124_I	1.302	0.95
124_I	150_L	1.302	0.95
32_D	35_L	1.297	0.95
184_K	195_T	1.282	0.94
103_L	128_G	1.279	0.94
10_K	14_I	1.275	0.94
153_V	178_S	1.267	0.94
63_K	111_K	1.246	0.94
88_P	108_G	1.242	0.93
78_N	98_L	1.219	0.93
117_G	140_D	1.207	0.92
118_I	138_Y	1.189	0.92
198_L	201_D	1.174	0.91
34_F	37_A	1.172	0.91
111_K	168_V	1.138	0.90
66_I	69_G	1.128	0.90
99_S	169_G	1.128	0.90
89_S	133_I	1.125	0.90
107_E	163_G	1.114	0.89
189_L	192_P	1.111	0.89
19_K	22_K	1.109	0.89
12_G	30_F	1.069	0.87
151_T	177_G	1.068	0.87
48_R	68_N	1.066	0.87
117_G	121_I	1.063	0.87
122_D	165_I	1.061	0.87
69_G	85_N	1.061	0.87
104_P	128_G	1.054	0.86
81_L	128_G	1.053	0.86
163_G	169_G	1.048	0.86
103_L	159_N	1.045	0.86
36_N	41_F	1.040	0.85
85_N	88_P	1.040	0.85
23_F	26_K	1.040	0.85
135_G	183_F	1.039	0.85
150_L	185_I	1.026	0.85
201_D	208_N	1.020	0.84
86_T	89_S	1.012	0.84
78_N	86_T	1.011	0.84
169_G	173_L	0.999	0.83
78_N	85_N	0.994	0.83
82_A	86_T	0.983	0.82
130_S	133_I	0.981	0.82
158_L	165_I	0.979	0.82
116_D	195_T	0.973	0.81
46_G	115_K	0.964	0.81
22_K	26_K	0.961	0.81
155_A	159_N	0.954	0.80
168_V	172_L	0.952	0.80
160_K	164_K	0.942	0.79
37_A	41_F	0.936	0.79
173_L	176_D	0.936	0.79
88_P	91_L	0.934	0.79
68_N	84_I	0.927	0.78
87_I	96_P	0.927	0.78
79_N	85_N	0.921	0.78
26_K	29_N	0.912	0.77
204_K	208_N	0.910	0.77
105_F	154_P	0.907	0.77
69_G	74_F	0.905	0.76
10_K	64_I	0.902	0.76
131_I	152_L	0.897	0.76
82_A	85_N	0.897	0.76
18_K	29_N	0.894	0.76
20_N	24_T	0.888	0.75
53_G	112_F	0.887	0.75
89_S	93_F	0.878	0.74
153_V	159_N	0.877	0.74
112_F	181_T	0.875	0.74
27_A	31_N	0.871	0.74
81_L	131_I	0.866	0.73
206_P	210_I	0.866	0.73
83_F	183_F	0.863	0.73
105_F	183_F	0.857	0.72
25_L	28_K	0.856	0.72
107_E	160_K	0.855	0.72
119_L	141_L	0.854	0.72
35_L	119_L	0.854	0.72
14_I	119_L	0.845	0.71
149_D	158_L	0.843	0.71
79_N	83_F	0.842	0.71
133_I	164_K	0.838	0.71
186_K	195_T	0.835	0.70
64_I	125_Y	0.812	0.68
117_G	124_I	0.801	0.67
35_L	41_F	0.795	0.67
22_K	140_D	0.789	0.66
79_N	86_T	0.777	0.65
23_F	27_A	0.777	0.65
53_G	60_L	0.775	0.65
13_K	19_K	0.775	0.65
21_N	117_G	0.775	0.65
139_I	189_L	0.773	0.64
198_L	202_I	0.767	0.64
23_F	38_L	0.767	0.64
114_L	172_L	0.763	0.63
12_G	31_N	0.756	0.63
82_A	96_P	0.755	0.63
126_L	150_L	0.755	0.63
17_K	28_K	0.753	0.62
48_R	67_K	0.749	0.62
57_D	128_G	0.748	0.62
16_F	24_T	0.747	0.62
80_I	98_L	0.747	0.62
24_T	28_K	0.747	0.62
110_I	124_I	0.743	0.61
139_I	144_K	0.740	0.61
62_G	126_L	0.738	0.61
197_N	206_P	0.738	0.61
162_I	173_L	0.736	0.61
103_L	170_Y	0.731	0.60
75_K	85_N	0.731	0.60
71_I	195_T	0.731	0.60
170_Y	173_L	0.729	0.60
35_L	40_N	0.728	0.60
113_S	141_L	0.728	0.60
84_I	147_D	0.727	0.60
32_D	40_N	0.722	0.59
71_I	107_E	0.722	0.59
140_D	145_T	0.722	0.59
128_G	156_K	0.722	0.59
104_P	131_I	0.716	0.59
62_G	176_D	0.714	0.58
13_K	20_N	0.711	0.58
200_K	204_K	0.710	0.58
84_I	103_L	0.709	0.58
190_D	193_K	0.708	0.58
15_K	22_K	0.700	0.57
91_L	132_D	0.700	0.57
116_D	172_L	0.699	0.57
79_N	212_R	0.698	0.57
132_D	150_L	0.698	0.57
80_I	112_F	0.696	0.56
123_D	210_I	0.696	0.56
42_K	46_G	0.695	0.56
186_K	193_K	0.694	0.56
128_G	196_T	0.688	0.56
13_K	16_F	0.687	0.55
168_V	171_I	0.685	0.55
17_K	71_I	0.684	0.55
83_F	97_G	0.682	0.55
89_S	97_G	0.681	0.55
208_N	212_R	0.680	0.55
31_N	34_F	0.680	0.55
82_A	98_L	0.676	0.54
126_L	133_I	0.674	0.54
17_K	21_N	0.672	0.54
67_K	78_N	0.672	0.54
49_L	109_Y	0.671	0.54
61_K	113_S	0.668	0.53
200_K	203_L	0.666	0.53
28_K	31_N	0.662	0.53
92_T	100_G	0.662	0.53
70_T	210_I	0.661	0.53
24_T	148_L	0.660	0.52
18_K	24_T	0.658	0.52
134_L	160_K	0.655	0.52
199_A	204_K	0.654	0.52
88_P	98_L	0.652	0.52
79_N	88_P	0.652	0.52
32_D	39_L	0.646	0.51
154_P	159_N	0.642	0.51
35_L	39_L	0.640	0.50
17_K	26_K	0.639	0.50
45_K	72_K	0.639	0.50
95_L	128_G	0.636	0.50
209_I	212_R	0.633	0.50
21_N	113_S	0.632	0.49
14_I	18_K	0.629	0.49
107_E	127_D	0.629	0.49
66_I	162_I	0.627	0.49
55_G	59_N	0.626	0.49
88_P	92_T	0.622	0.48
36_N	39_L	0.621	0.48
164_K	167_L	0.620	0.48
150_L	209_I	0.620	0.48
11_N	31_N	0.620	0.48
74_F	152_L	0.618	0.48
151_T	182_S	0.615	0.48
64_I	211_K	0.613	0.47
15_K	24_T	0.611	0.47
79_N	170_Y	0.606	0.47
126_L	185_I	0.604	0.46
159_N	181_T	0.603	0.46
36_N	44_F	0.602	0.46
198_L	208_N	0.602	0.46
20_N	23_F	0.602	0.46
179_I	189_L	0.600	0.46
127_D	189_L	0.595	0.45
136_K	139_I	0.595	0.45
81_L	202_I	0.586	0.44
69_G	78_N	0.585	0.44
24_T	27_A	0.583	0.44
77_L	152_L	0.582	0.44
73_D	81_L	0.582	0.44
97_G	170_Y	0.579	0.44
14_I	22_K	0.578	0.43
44_F	125_Y	0.577	0.43
29_N	191_D	0.577	0.43
31_N	35_L	0.577	0.43
15_K	26_K	0.577	0.43
186_K	194_V	0.569	0.43
10_K	13_K	0.569	0.43
10_K	15_K	0.567	0.42
10_K	18_K	0.565	0.42
12_G	16_F	0.562	0.42
11_N	18_K	0.561	0.42
83_F	181_T	0.561	0.42
60_L	140_D	0.561	0.42
82_A	88_P	0.561	0.42
64_I	142_K	0.559	0.41
104_P	110_I	0.557	0.41
50_D	67_K	0.556	0.41
78_N	89_S	0.556	0.41
116_D	142_K	0.555	0.41
156_K	169_G	0.554	0.41
64_I	110_I	0.553	0.41
143_K	188_P	0.550	0.40
145_T	191_D	0.549	0.40
198_L	203_L	0.549	0.40
22_K	56_P	0.548	0.40
120_T	138_Y	0.545	0.40
60_L	70_T	0.542	0.40
155_A	202_I	0.542	0.40
63_K	130_S	0.542	0.40
29_N	37_A	0.538	0.39
107_E	110_I	0.537	0.39
49_L	156_K	0.537	0.39
121_I	182_S	0.535	0.39
80_I	183_F	0.532	0.39
88_P	135_G	0.531	0.39
11_N	29_N	0.528	0.38
65_K	167_L	0.528	0.38
79_N	98_L	0.524	0.38
47_G	69_G	0.519	0.37
16_F	27_A	0.518	0.37
53_G	110_I	0.518	0.37
201_D	204_K	0.516	0.37
51_F	114_L	0.515	0.37
10_K	17_K	0.515	0.37
15_K	19_K	0.514	0.37
56_P	59_N	0.512	0.37
25_L	37_A	0.511	0.36
104_P	129_P	0.511	0.36
79_N	171_I	0.507	0.36
183_F	202_I	0.506	0.36
162_I	174_G	0.500	0.35
58_K	191_D	0.500	0.35

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4kt5A	2	0.486	11.6	0.947	Contact Map
4qq0A	1	0.6776	4.1	0.957	Contact Map
3d33A	1	0.3084	3	0.959	Contact Map
2ovsA	2	0.4907	2.7	0.961	Contact Map
4nurA	2	0.4112	1.9	0.964	Contact Map
2cfuA	2	0.4206	1.9	0.964	Contact Map
3sd2A	2	0.3084	1.7	0.965	Contact Map
2ks0A	2	0.2664	1.5	0.966	Contact Map
3go5A	1	0.4112	1.4	0.966	Contact Map
4g75A	1	0.271	1.3	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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