GREMLIN Database
AsmA_1 - AsmA-like C-terminal region
PFAM: PF13109 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 214 (204)
Sequences: 1073 (822)
Seq/√Len: 57.5
META: 0.89

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_I124_I5.2311.00
144_K190_D4.8711.00
203_L206_P3.6281.00
140_D143_K3.6241.00
114_L119_L3.4101.00
137_G148_L3.3051.00
124_I135_G3.2671.00
62_G112_F3.2201.00
145_T188_P2.8691.00
135_G150_L2.5871.00
208_N211_K2.5791.00
35_L38_L2.5241.00
199_A202_I2.3651.00
113_S122_D2.1941.00
89_S92_T2.1831.00
148_L185_I2.1221.00
14_I30_F2.0991.00
110_I121_I1.9901.00
79_N82_A1.9281.00
146_I189_L1.9031.00
138_Y147_D1.8741.00
117_G142_K1.8621.00
74_F78_N1.8030.99
58_K146_I1.7670.99
210_I213_T1.7580.99
132_D156_K1.7500.99
111_K123_D1.7490.99
200_K207_L1.7420.99
118_I140_D1.7000.99
208_N213_T1.7000.99
173_L179_I1.6990.99
80_I194_V1.6960.99
27_A30_F1.6800.99
205_A209_I1.6460.99
188_P191_D1.6380.99
77_L131_I1.6160.99
198_L206_P1.5640.98
13_K17_K1.5590.98
93_F96_P1.5480.98
205_A208_N1.5390.98
11_N15_K1.5040.98
144_K188_P1.4720.98
106_K127_D1.4660.97
69_G75_K1.4160.97
90_L93_F1.4110.97
79_N97_G1.4010.97
151_T180_S1.3810.96
78_N82_A1.3810.96
71_I78_N1.3720.96
75_K78_N1.3570.96
10_K33_K1.3570.96
201_D206_P1.3470.96
11_N17_K1.3380.96
34_F38_L1.3270.95
102_G128_G1.3240.95
197_N201_D1.3110.95
126_L139_I1.3100.95
156_K159_N1.3060.95
119_L124_I1.3020.95
124_I150_L1.3020.95
32_D35_L1.2970.95
184_K195_T1.2820.94
103_L128_G1.2790.94
10_K14_I1.2750.94
153_V178_S1.2670.94
63_K111_K1.2460.94
88_P108_G1.2420.93
78_N98_L1.2190.93
117_G140_D1.2070.92
118_I138_Y1.1890.92
198_L201_D1.1740.91
34_F37_A1.1720.91
111_K168_V1.1380.90
66_I69_G1.1280.90
99_S169_G1.1280.90
89_S133_I1.1250.90
107_E163_G1.1140.89
189_L192_P1.1110.89
19_K22_K1.1090.89
12_G30_F1.0690.87
151_T177_G1.0680.87
48_R68_N1.0660.87
117_G121_I1.0630.87
122_D165_I1.0610.87
69_G85_N1.0610.87
104_P128_G1.0540.86
81_L128_G1.0530.86
163_G169_G1.0480.86
103_L159_N1.0450.86
36_N41_F1.0400.85
85_N88_P1.0400.85
23_F26_K1.0400.85
135_G183_F1.0390.85
150_L185_I1.0260.85
201_D208_N1.0200.84
86_T89_S1.0120.84
78_N86_T1.0110.84
169_G173_L0.9990.83
78_N85_N0.9940.83
82_A86_T0.9830.82
130_S133_I0.9810.82
158_L165_I0.9790.82
116_D195_T0.9730.81
46_G115_K0.9640.81
22_K26_K0.9610.81
155_A159_N0.9540.80
168_V172_L0.9520.80
160_K164_K0.9420.79
37_A41_F0.9360.79
173_L176_D0.9360.79
88_P91_L0.9340.79
68_N84_I0.9270.78
87_I96_P0.9270.78
79_N85_N0.9210.78
26_K29_N0.9120.77
204_K208_N0.9100.77
105_F154_P0.9070.77
69_G74_F0.9050.76
10_K64_I0.9020.76
131_I152_L0.8970.76
82_A85_N0.8970.76
18_K29_N0.8940.76
20_N24_T0.8880.75
53_G112_F0.8870.75
89_S93_F0.8780.74
153_V159_N0.8770.74
112_F181_T0.8750.74
27_A31_N0.8710.74
81_L131_I0.8660.73
206_P210_I0.8660.73
83_F183_F0.8630.73
105_F183_F0.8570.72
25_L28_K0.8560.72
107_E160_K0.8550.72
119_L141_L0.8540.72
35_L119_L0.8540.72
14_I119_L0.8450.71
149_D158_L0.8430.71
79_N83_F0.8420.71
133_I164_K0.8380.71
186_K195_T0.8350.70
64_I125_Y0.8120.68
117_G124_I0.8010.67
35_L41_F0.7950.67
22_K140_D0.7890.66
79_N86_T0.7770.65
23_F27_A0.7770.65
53_G60_L0.7750.65
13_K19_K0.7750.65
21_N117_G0.7750.65
139_I189_L0.7730.64
198_L202_I0.7670.64
23_F38_L0.7670.64
114_L172_L0.7630.63
12_G31_N0.7560.63
82_A96_P0.7550.63
126_L150_L0.7550.63
17_K28_K0.7530.62
48_R67_K0.7490.62
57_D128_G0.7480.62
16_F24_T0.7470.62
80_I98_L0.7470.62
24_T28_K0.7470.62
110_I124_I0.7430.61
139_I144_K0.7400.61
62_G126_L0.7380.61
197_N206_P0.7380.61
162_I173_L0.7360.61
103_L170_Y0.7310.60
75_K85_N0.7310.60
71_I195_T0.7310.60
170_Y173_L0.7290.60
35_L40_N0.7280.60
113_S141_L0.7280.60
84_I147_D0.7270.60
32_D40_N0.7220.59
71_I107_E0.7220.59
140_D145_T0.7220.59
128_G156_K0.7220.59
104_P131_I0.7160.59
62_G176_D0.7140.58
13_K20_N0.7110.58
200_K204_K0.7100.58
84_I103_L0.7090.58
190_D193_K0.7080.58
15_K22_K0.7000.57
91_L132_D0.7000.57
116_D172_L0.6990.57
79_N212_R0.6980.57
132_D150_L0.6980.57
80_I112_F0.6960.56
123_D210_I0.6960.56
42_K46_G0.6950.56
186_K193_K0.6940.56
128_G196_T0.6880.56
13_K16_F0.6870.55
168_V171_I0.6850.55
17_K71_I0.6840.55
83_F97_G0.6820.55
89_S97_G0.6810.55
208_N212_R0.6800.55
31_N34_F0.6800.55
82_A98_L0.6760.54
126_L133_I0.6740.54
17_K21_N0.6720.54
67_K78_N0.6720.54
49_L109_Y0.6710.54
61_K113_S0.6680.53
200_K203_L0.6660.53
28_K31_N0.6620.53
92_T100_G0.6620.53
70_T210_I0.6610.53
24_T148_L0.6600.52
18_K24_T0.6580.52
134_L160_K0.6550.52
199_A204_K0.6540.52
88_P98_L0.6520.52
79_N88_P0.6520.52
32_D39_L0.6460.51
154_P159_N0.6420.51
35_L39_L0.6400.50
17_K26_K0.6390.50
45_K72_K0.6390.50
95_L128_G0.6360.50
209_I212_R0.6330.50
21_N113_S0.6320.49
14_I18_K0.6290.49
107_E127_D0.6290.49
66_I162_I0.6270.49
55_G59_N0.6260.49
88_P92_T0.6220.48
36_N39_L0.6210.48
164_K167_L0.6200.48
150_L209_I0.6200.48
11_N31_N0.6200.48
74_F152_L0.6180.48
151_T182_S0.6150.48
64_I211_K0.6130.47
15_K24_T0.6110.47
79_N170_Y0.6060.47
126_L185_I0.6040.46
159_N181_T0.6030.46
36_N44_F0.6020.46
198_L208_N0.6020.46
20_N23_F0.6020.46
179_I189_L0.6000.46
127_D189_L0.5950.45
136_K139_I0.5950.45
81_L202_I0.5860.44
69_G78_N0.5850.44
24_T27_A0.5830.44
77_L152_L0.5820.44
73_D81_L0.5820.44
97_G170_Y0.5790.44
14_I22_K0.5780.43
44_F125_Y0.5770.43
29_N191_D0.5770.43
31_N35_L0.5770.43
15_K26_K0.5770.43
186_K194_V0.5690.43
10_K13_K0.5690.43
10_K15_K0.5670.42
10_K18_K0.5650.42
12_G16_F0.5620.42
11_N18_K0.5610.42
83_F181_T0.5610.42
60_L140_D0.5610.42
82_A88_P0.5610.42
64_I142_K0.5590.41
104_P110_I0.5570.41
50_D67_K0.5560.41
78_N89_S0.5560.41
116_D142_K0.5550.41
156_K169_G0.5540.41
64_I110_I0.5530.41
143_K188_P0.5500.40
145_T191_D0.5490.40
198_L203_L0.5490.40
22_K56_P0.5480.40
120_T138_Y0.5450.40
60_L70_T0.5420.40
155_A202_I0.5420.40
63_K130_S0.5420.40
29_N37_A0.5380.39
107_E110_I0.5370.39
49_L156_K0.5370.39
121_I182_S0.5350.39
80_I183_F0.5320.39
88_P135_G0.5310.39
11_N29_N0.5280.38
65_K167_L0.5280.38
79_N98_L0.5240.38
47_G69_G0.5190.37
16_F27_A0.5180.37
53_G110_I0.5180.37
201_D204_K0.5160.37
51_F114_L0.5150.37
10_K17_K0.5150.37
15_K19_K0.5140.37
56_P59_N0.5120.37
25_L37_A0.5110.36
104_P129_P0.5110.36
79_N171_I0.5070.36
183_F202_I0.5060.36
162_I174_G0.5000.35
58_K191_D0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kt5A 2 0.486 11.6 0.947 Contact Map
4qq0A 1 0.6776 4.1 0.957 Contact Map
3d33A 1 0.3084 3 0.959 Contact Map
2ovsA 2 0.4907 2.7 0.961 Contact Map
4nurA 2 0.4112 1.9 0.964 Contact Map
2cfuA 2 0.4206 1.9 0.964 Contact Map
3sd2A 2 0.3084 1.7 0.965 Contact Map
2ks0A 2 0.2664 1.5 0.966 Contact Map
3go5A 1 0.4112 1.4 0.966 Contact Map
4g75A 1 0.271 1.3 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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