GREMLIN Database
DUF3943 - Domain of unknown function (DUF3943)
PFAM: PF13084 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 107 (104)
Sequences: 5103 (2893)
Seq/√Len: 283.6
META: 0.966

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_F99_L3.5911.00
33_N36_E3.4741.00
38_F71_S3.3491.00
27_A40_Y3.0901.00
42_F67_P2.9211.00
32_L40_Y2.3501.00
43_A47_L2.3051.00
24_Y34_F2.2251.00
32_L36_E2.1511.00
46_L50_Y1.7421.00
89_A93_P1.7351.00
92_G96_W1.7321.00
24_Y41_A1.7301.00
7_D56_E1.7281.00
39_L43_A1.6821.00
84_I104_I1.6431.00
94_R98_E1.5841.00
47_L51_F1.5561.00
42_F63_L1.5431.00
96_W100_G1.5201.00
2_W50_Y1.5011.00
78_F82_S1.4871.00
49_E56_E1.4581.00
38_F67_P1.4561.00
11_T15_G1.4211.00
23_Y44_G1.4041.00
85_L101_A1.3691.00
13_Q65_N1.3221.00
99_L103_L1.2821.00
93_P97_R1.2701.00
15_G19_Q1.2621.00
43_A46_L1.2581.00
22_L26_A1.2571.00
21_S73_L1.2501.00
19_Q23_Y1.2461.00
3_V56_E1.2341.00
34_F71_S1.2281.00
12_N49_E1.2231.00
39_L42_F1.2221.00
10_S14_F1.2111.00
94_R97_R1.1931.00
3_V57_P1.1611.00
99_L102_A1.1501.00
41_A67_P1.1421.00
75_E78_F1.1121.00
81_S85_L1.1071.00
76_A80_L1.0951.00
84_I100_G1.0941.00
65_N69_G1.0881.00
25_N105_D1.0841.00
35_W39_L1.0761.00
64_I68_I1.0681.00
25_N77_L1.0601.00
80_L83_L1.0381.00
27_A32_L1.0371.00
33_N37_S1.0351.00
38_F42_F1.0201.00
2_W63_L1.0191.00
38_F68_I1.0081.00
90_T94_R0.9971.00
26_A30_N0.9951.00
8_P11_T0.9901.00
3_V7_D0.9441.00
92_G99_L0.9351.00
63_L67_P0.9231.00
45_S66_T0.9181.00
23_Y66_T0.9171.00
82_S85_L0.9101.00
48_W75_E0.9101.00
78_F105_D0.8921.00
46_L63_L0.8901.00
96_W99_L0.8581.00
37_S41_A0.8551.00
25_N78_F0.8321.00
50_Y58_P0.8291.00
49_E59_S0.8201.00
68_I72_F0.8171.00
93_P98_E0.8171.00
98_E102_A0.8040.99
47_L52_G0.8020.99
10_S15_G0.7970.99
91_G94_R0.7950.99
34_F79_R0.7900.99
21_S25_N0.7860.99
42_F46_L0.7810.99
89_A92_G0.7750.99
24_Y71_S0.7730.99
90_T93_P0.7700.99
91_G98_E0.7620.99
77_L80_L0.7410.99
75_E79_R0.7400.99
29_S78_F0.7290.99
77_L81_S0.7240.99
18_Y22_L0.7150.99
86_D91_G0.7060.99
21_S77_L0.6970.98
34_F38_F0.6930.98
6_N56_E0.6830.98
92_G95_F0.6670.98
95_F100_G0.6600.98
41_A71_S0.6510.98
82_S105_D0.6440.97
65_N68_I0.6440.97
11_T19_Q0.6430.97
100_G104_I0.6430.97
5_D12_N0.6420.97
97_R104_I0.6420.97
4_W60_I0.6330.97
3_V60_I0.6310.97
89_A94_R0.6280.97
88_R92_G0.6270.97
36_E40_Y0.6240.97
50_Y57_P0.6240.97
47_L50_Y0.6240.97
64_I67_P0.6080.96
13_Q17_P0.6060.96
72_F87_N0.6000.96
25_N29_S0.6000.96
100_G103_L0.5920.96
22_L77_L0.5900.96
42_F68_I0.5900.96
19_Q22_L0.5900.96
61_N69_G0.5900.96
56_E59_S0.5880.96
12_N16_H0.5840.95
3_V6_N0.5810.95
81_S84_I0.5800.95
46_L67_P0.5800.95
24_Y37_S0.5800.95
59_S62_D0.5700.95
52_G56_E0.5680.95
86_D89_A0.5600.94
46_L66_T0.5480.94
85_L105_D0.5430.93
66_T69_G0.5410.93
50_Y63_L0.5390.93
50_Y60_I0.5370.93
88_R94_R0.5370.93
79_R83_L0.5360.93
80_L84_I0.5300.92
86_D93_P0.5290.92
92_G100_G0.5270.92
9_F13_Q0.5210.92
2_W6_N0.5180.92
73_L76_A0.5180.92
92_G97_R0.5130.91
89_A97_R0.5130.91
29_S81_S0.5110.91
31_G82_S0.5110.91
22_L25_N0.5070.91
95_F102_A0.5070.91
96_W103_L0.5070.91
49_E62_D0.5060.91
97_R101_A0.5040.90
23_Y49_E0.5020.90
82_S87_N0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v0aB 1 0.486 4.2 0.941 Contact Map
3lvhD 1 0 3.2 0.944 Contact Map
3b8cA 1 0.4953 2.7 0.947 Contact Map
4rp9A 2 0.9626 2.5 0.948 Contact Map
2kv5A 1 0.3084 2.2 0.949 Contact Map
3vuoA 1 0.4673 2 0.95 Contact Map
4o9uB 2 0.8505 1.8 0.951 Contact Map
3q9oA 1 0.8505 1.6 0.953 Contact Map
1i1qA 2 0.2991 1.6 0.953 Contact Map
3cbjA 1 0.3832 1.4 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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