GREMLIN Database
DUF3899 - Domain of unknown function (DUF3899)
PFAM: PF13038 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (84)
Sequences: 1048 (956)
Seq/√Len: 104.3
META: 0.651

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_G77_L3.4561.00
49_E57_E2.9841.00
24_G27_D2.8621.00
50_S53_E2.5791.00
20_V25_F2.3241.00
52_Y56_E2.2571.00
15_G73_G2.0221.00
8_G80_S1.8751.00
3_A7_V1.8701.00
13_I17_L1.8531.00
12_L73_G1.8291.00
20_V23_G1.8161.00
16_L19_F1.7171.00
51_Y55_K1.7091.00
5_F80_S1.6551.00
37_F40_F1.6401.00
4_L79_L1.6381.00
51_Y54_Y1.6311.00
31_Y54_Y1.5731.00
1_I5_F1.5041.00
6_I9_L1.4971.00
19_F23_G1.4311.00
11_L70_L1.3841.00
18_L22_N1.3711.00
1_I4_L1.3560.99
50_S54_Y1.3090.99
67_L70_L1.3080.99
1_I84_L1.2400.99
20_V26_F1.2350.99
17_L27_D1.2210.99
46_K50_S1.1380.98
15_G74_L1.1270.98
9_L13_I1.1000.98
1_I83_L1.0860.98
22_N27_D1.0800.97
71_I74_L1.0770.97
48_K51_Y1.0500.97
17_L30_S1.0410.97
27_D32_G1.0220.96
12_L16_L0.9980.96
13_I80_S0.9970.96
75_I81_I0.9970.96
79_L83_L0.9830.96
34_R43_K0.9760.95
1_I81_I0.9600.95
14_I69_L0.9600.95
32_G36_L0.9550.95
35_K41_F0.9420.94
18_L72_V0.9340.94
27_D55_K0.9290.94
75_I79_L0.9240.94
48_K54_Y0.9200.94
70_L74_L0.9010.93
33_F37_F0.9000.93
8_G73_G0.8680.92
4_L7_V0.8540.91
25_F28_G0.8470.91
30_S58_K0.8400.90
11_L32_G0.8340.90
71_I82_I0.8310.90
72_V75_I0.8250.89
69_L72_V0.8180.89
68_P71_I0.8130.89
5_F26_F0.8060.88
23_G29_F0.7990.88
30_S34_R0.7960.88
65_S74_L0.7930.87
35_K46_K0.7840.87
76_L80_S0.7720.86
17_L24_G0.7700.86
22_N33_F0.7550.85
31_Y35_K0.7430.84
56_E59_K0.7370.83
27_D33_F0.7360.83
6_I10_L0.7330.83
54_Y58_K0.7300.83
13_I16_L0.7300.83
54_Y57_E0.7220.82
22_N66_T0.7150.81
49_E53_E0.7120.81
15_G80_S0.7100.81
1_I30_S0.7030.80
52_Y59_K0.6990.80
4_L72_V0.6940.80
9_L18_L0.6930.79
46_K49_E0.6910.79
74_L78_L0.6840.79
10_L44_K0.6800.78
45_K49_E0.6790.78
5_F77_L0.6740.78
23_G28_G0.6600.76
47_K51_Y0.6600.76
28_G35_K0.6590.76
30_S57_E0.6480.75
22_N32_G0.6270.72
46_K56_E0.6220.72
39_R51_Y0.6180.71
24_G32_G0.6170.71
62_K69_L0.6110.70
15_G70_L0.6090.70
1_I21_S0.5960.68
13_I34_R0.5930.68
29_F33_F0.5920.68
48_K63_K0.5890.68
49_E71_I0.5850.67
11_L73_G0.5810.67
72_V76_L0.5770.66
32_G40_F0.5710.65
3_A8_G0.5670.65
5_F25_F0.5640.64
59_K84_L0.5630.64
63_K66_T0.5590.64
46_K60_E0.5440.61
38_R47_K0.5440.61
72_V79_L0.5410.61
16_L63_K0.5410.61
41_F44_K0.5340.60
55_K59_K0.5290.59
13_I18_L0.5240.59
12_L77_L0.5220.58
19_F68_P0.5170.58
4_L80_S0.5090.56
66_T70_L0.5080.56
18_L74_L0.5040.56
2_N70_L0.5020.55
37_F77_L0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3owqA 1 0 8 0.856 Contact Map
3j9pD 4 0.9412 6.7 0.861 Contact Map
2bg9A 1 0.9412 6.6 0.862 Contact Map
4r1iA 2 0.4353 6.4 0.863 Contact Map
4nv5A 1 0.3059 5.3 0.868 Contact Map
4r0cA 3 0.2941 5.3 0.868 Contact Map
2kncA 1 0.4824 5.2 0.869 Contact Map
2bg9B 1 0.9412 5.1 0.869 Contact Map
2onkC 2 0.2588 5.1 0.869 Contact Map
2bg9E 1 0.9412 4.6 0.872 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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