GREMLIN Database
DUF3892 - Protein of unknown function (DUF3892)
PFAM: PF13031 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (85)
Sequences: 5995 (4780)
Seq/√Len: 518.4
META: 0.901

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_E67_K5.0641.00
39_G45_W2.7241.00
4_C21_G2.5621.00
19_H30_K2.5001.00
20_V69_L2.4911.00
60_V70_R2.2871.00
58_I72_E2.2361.00
31_L39_G2.0731.00
20_V36_A2.0541.00
39_G47_F2.0441.00
50_S54_R2.0341.00
74_D79_D1.9941.00
46_T56_D1.9321.00
32_T35_E1.9141.00
31_L36_A1.7721.00
38_A42_S1.7181.00
22_G25_G1.7071.00
2_I20_V1.6531.00
6_R30_K1.6001.00
56_D72_E1.5981.00
41_E59_V1.5151.00
61_V67_K1.4701.00
31_L47_F1.4591.00
8_D18_T1.4091.00
6_R19_H1.3861.00
34_E38_A1.3491.00
37_I59_V1.3351.00
36_A69_L1.3141.00
35_E38_A1.2981.00
62_S65_G1.2311.00
39_G44_T1.2221.00
1_Q50_S1.1911.00
33_R66_R1.1431.00
77_W83_S1.1041.00
35_E39_G1.1001.00
8_D12_D1.0951.00
19_H32_T1.0741.00
58_I70_R1.0541.00
71_T80_N0.9961.00
74_D80_N0.9911.00
53_K76_T0.9881.00
31_L35_E0.9351.00
7_K82_L0.9321.00
9_D12_D0.9191.00
12_D15_E0.9171.00
57_V69_L0.9071.00
70_R73_A0.8901.00
61_V64_N0.8771.00
37_I41_E0.8751.00
75_G78_P0.8721.00
62_S66_R0.8601.00
48_Y54_R0.8551.00
52_G55_A0.8501.00
31_L45_W0.8331.00
21_G30_K0.8121.00
40_I47_F0.8021.00
36_A39_G0.7991.00
72_E77_W0.7951.00
20_V33_R0.7931.00
50_S53_K0.7921.00
1_Q48_Y0.7741.00
16_R33_R0.7721.00
22_G28_R0.7651.00
48_Y56_D0.7571.00
45_W48_Y0.7471.00
36_A40_I0.7441.00
8_D11_G0.7401.00
49_V55_A0.7361.00
7_K11_G0.7331.00
60_V68_Y0.7311.00
8_D15_E0.7151.00
25_G29_W0.7091.00
62_S67_K0.7021.00
73_A80_N0.6981.00
25_G28_R0.6951.00
80_N83_S0.6951.00
22_G27_T0.6931.00
33_R68_Y0.6921.00
37_I67_K0.6891.00
36_A47_F0.6891.00
20_V40_I0.6891.00
59_V67_K0.6811.00
1_Q23_P0.6731.00
17_I20_V0.6681.00
41_E61_V0.6651.00
33_R69_L0.6651.00
23_P28_R0.6591.00
28_R39_G0.6531.00
27_T31_L0.6271.00
37_I40_I0.6271.00
10_R13_P0.6221.00
72_E78_P0.6041.00
11_G16_R0.6031.00
23_P27_T0.6001.00
73_A77_W0.5940.99
81_L84_L0.5810.99
58_I77_W0.5780.99
55_A58_I0.5760.99
72_E75_G0.5730.99
20_V57_V0.5720.99
70_R79_D0.5680.99
29_W47_F0.5660.99
38_A41_E0.5640.99
53_K56_D0.5600.99
5_I17_I0.5580.99
70_R77_W0.5560.99
43_G46_T0.5550.99
24_D27_T0.5520.99
57_V60_V0.5520.99
3_T22_G0.5510.99
51_G76_T0.5440.99
49_V80_N0.5410.99
37_I69_L0.5390.99
29_W39_G0.5350.99
34_E37_I0.5330.99
23_P26_G0.5330.99
53_K79_D0.5290.99
4_C7_K0.5270.99
46_T49_V0.5260.99
78_P82_L0.5250.99
38_A44_T0.5250.99
6_R10_R0.5200.99
70_R74_D0.5180.99
70_R78_P0.5160.99
63_R76_T0.5160.99
40_I43_G0.5070.98
75_G80_N0.5040.98
61_V66_R0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r4fA 4 0.8588 5.4 0.884 Contact Map
2hhzA 2 0.6471 5 0.886 Contact Map
1efvA 1 0.4353 3.4 0.895 Contact Map
3j60K 1 0.7412 3.2 0.896 Contact Map
3k2tA 1 0.6118 3.2 0.897 Contact Map
4ekxC 2 0.2941 3.1 0.897 Contact Map
1o97D 1 0.4235 3.1 0.898 Contact Map
3a98B 1 0.8588 3 0.898 Contact Map
4lo6A 1 0.4235 2.8 0.899 Contact Map
2fiyA 1 0.9059 2.7 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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