GREMLIN Database
DUF3891 - Protein of unknown function (DUF3891)
PFAM: PF13030 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 218 (216)
Sequences: 3165 (2317)
Seq/√Len: 157.6
META: 0.891

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_S97_D4.3191.00
99_Y149_N4.0931.00
65_D76_E3.5081.00
128_Q131_R3.4561.00
87_R127_E3.1951.00
105_S128_Q2.7861.00
41_R45_L2.6021.00
91_D131_R2.4801.00
105_S132_Q2.3881.00
28_A203_A2.3661.00
50_E53_D2.3621.00
110_G150_Y2.1981.00
200_W206_P2.1441.00
26_A156_C2.1311.00
19_A22_A2.1101.00
23_G49_A2.1021.00
109_T132_Q2.0631.00
191_G194_R2.0511.00
94_A134_R2.0431.00
27_R49_A2.0251.00
24_Q27_R2.0111.00
3_V12_L2.0031.00
14_T17_D1.9921.00
188_R196_T1.9701.00
31_N34_F1.9691.00
48_A156_C1.9431.00
36_R41_R1.9171.00
97_D100_A1.9111.00
57_E88_R1.8801.00
160_S164_C1.8571.00
39_P149_N1.8321.00
93_L101_G1.8311.00
44_V103_L1.7851.00
65_D68_T1.7701.00
72_Y78_P1.7701.00
131_R135_L1.7181.00
17_D20_R1.6981.00
63_T72_Y1.6371.00
46_L50_E1.6001.00
173_E176_V1.5881.00
123_A127_E1.5771.00
63_T81_E1.5681.00
197_L202_F1.5611.00
53_D92_R1.5581.00
6_T9_G1.5561.00
143_E147_E1.5421.00
78_P81_E1.5401.00
177_P180_P1.5161.00
176_V179_G1.5121.00
134_R138_E1.4511.00
93_L100_A1.4431.00
94_A101_G1.4331.00
118_R122_D1.4231.00
6_T11_L1.4121.00
29_W201_P1.3991.00
27_R45_L1.3761.00
57_E92_R1.3431.00
106_M146_L1.3391.00
136_R143_E1.3191.00
136_R146_L1.2861.00
21_L163_F1.2701.00
86_W108_G1.2581.00
147_E150_Y1.2581.00
28_A207_L1.2581.00
110_G154_Q1.2511.00
50_E96_Q1.2461.00
102_L132_Q1.2451.00
93_L104_V1.2431.00
21_L25_L1.2421.00
168_P171_G1.2331.00
13_I164_C1.2281.00
9_G215_R1.2201.00
113_E116_Y1.2191.00
106_M150_Y1.2061.00
93_L97_D1.2051.00
172_R175_E1.2041.00
86_W89_G1.1831.00
80_E120_E1.1831.00
4_R11_L1.1821.00
82_H112_Y1.1721.00
17_D212_E1.1691.00
179_G183_A1.1671.00
23_G48_A1.1571.00
20_R24_Q1.1561.00
122_D126_A1.1291.00
200_W204_G1.1271.00
22_A160_S1.1261.00
98_P138_E1.1191.00
171_G174_L1.1181.00
133_A137_A1.1151.00
159_L197_L1.1091.00
102_L139_L1.1041.00
47_A104_V1.0940.99
16_P59_D1.0910.99
185_L197_L1.0820.99
6_T215_R1.0770.99
53_D89_G1.0720.99
105_S109_T1.0690.99
30_G34_F1.0680.99
168_P175_E1.0670.99
59_D77_V1.0630.99
119_P123_A1.0630.99
22_A156_C1.0610.99
4_R13_I1.0530.99
128_Q132_Q1.0510.99
168_P173_E1.0490.99
173_E177_P1.0380.99
176_V181_D1.0000.99
44_V149_N0.9970.99
25_L156_C0.9970.99
21_L209_V0.9890.99
39_P44_V0.9890.99
94_A131_R0.9800.99
171_G175_E0.9730.99
85_L89_G0.9710.99
75_L165_L0.9670.99
130_A133_A0.9550.99
108_G112_Y0.9550.99
112_Y125_L0.9510.99
106_M147_E0.9500.99
58_W63_T0.9360.98
202_F207_L0.9360.98
53_D56_A0.9250.98
46_L96_Q0.9230.98
170_E173_E0.9190.98
25_L209_V0.9030.98
73_D76_E0.8940.98
46_L100_A0.8920.98
180_P183_A0.8910.98
90_I128_Q0.8900.98
110_G116_Y0.8830.98
126_A129_E0.8760.97
15_Q18_H0.8730.97
177_P181_D0.8680.97
130_A134_R0.8670.97
176_V180_P0.8670.97
14_T59_D0.8620.97
178_L182_G0.8580.97
3_V10_W0.8510.97
175_E179_G0.8510.97
26_A48_A0.8510.97
11_L213_A0.8430.97
175_E178_L0.8430.97
89_G93_L0.8430.97
128_Q135_L0.8380.97
178_L183_A0.8360.97
82_H85_L0.8350.97
5_E10_W0.8330.97
168_P172_R0.8320.97
178_L181_D0.8310.97
38_E41_R0.8290.96
188_R191_G0.8280.96
150_Y154_Q0.8140.96
84_A88_R0.8120.96
55_W77_V0.8090.96
82_H89_G0.8050.96
81_E84_A0.8030.96
89_G108_G0.8000.96
45_L48_A0.7990.96
102_L106_M0.7960.96
30_G39_P0.7930.95
77_V81_E0.7930.95
64_L69_G0.7920.95
74_F161_L0.7890.95
43_S100_A0.7870.95
16_P56_A0.7810.95
19_A23_G0.7800.95
46_L97_D0.7790.95
124_F128_Q0.7730.95
120_E123_A0.7700.95
43_S46_L0.7700.95
21_L164_C0.7620.94
80_E117_D0.7610.94
11_L215_R0.7610.94
72_Y76_E0.7590.94
15_Q19_A0.7540.94
106_M132_Q0.7500.94
168_P177_P0.7470.94
133_A143_E0.7450.94
171_G176_V0.7450.94
23_G26_A0.7450.94
25_L159_L0.7440.94
119_P122_D0.7410.94
110_G147_E0.7400.94
46_L92_R0.7400.94
55_W59_D0.7350.93
174_L177_P0.7340.93
190_L194_R0.7330.93
30_G37_P0.7310.93
159_L187_L0.7310.93
27_R42_E0.7300.93
22_A48_A0.7280.93
23_G27_R0.7270.93
29_W155_F0.7260.93
77_V85_L0.7260.93
175_E182_G0.7230.93
18_H51_H0.7190.93
147_E151_R0.7180.92
55_W85_L0.7130.92
48_A150_Y0.7090.92
55_W89_G0.7080.92
187_L197_L0.7070.92
154_Q158_L0.7050.92
86_W90_I0.7050.92
127_E130_A0.7030.92
170_E174_L0.7000.92
63_T80_E0.6990.91
185_L188_R0.6960.91
31_N37_P0.6940.91
172_R177_P0.6920.91
54_G86_W0.6860.91
168_P174_L0.6850.91
179_G182_G0.6850.91
66_P72_Y0.6830.90
123_A133_A0.6830.90
16_P20_R0.6820.90
47_A103_L0.6820.90
77_V86_W0.6820.90
155_F185_L0.6790.90
94_A135_L0.6770.90
86_W97_D0.6760.90
5_E70_R0.6740.90
140_G145_E0.6690.90
91_D127_E0.6690.90
54_G85_L0.6640.89
14_T214_R0.6640.89
155_F159_L0.6610.89
115_R150_Y0.6600.89
174_L187_L0.6600.89
173_E186_T0.6590.89
70_R76_E0.6580.89
129_E133_A0.6570.89
136_R140_G0.6570.89
150_Y158_L0.6560.89
55_W62_P0.6520.88
123_A126_A0.6490.88
82_H86_W0.6490.88
19_A164_C0.6480.88
116_Y150_Y0.6470.88
152_L202_F0.6460.88
167_E171_G0.6430.88
109_T125_L0.6420.88
42_E45_L0.6380.87
58_W85_L0.6360.87
98_P135_L0.6340.87
37_P152_L0.6340.87
175_E180_P0.6300.87
16_P19_A0.6280.86
90_I124_F0.6250.86
103_L153_L0.6240.86
28_A204_G0.6240.86
19_A53_D0.6230.86
129_E132_Q0.6200.86
185_L189_P0.6200.86
88_R92_R0.6200.86
31_N203_A0.6180.86
184_R187_L0.6150.85
83_L112_Y0.6150.85
90_I108_G0.6130.85
88_R91_D0.6130.85
80_E84_A0.6120.85
25_L163_F0.6090.85
99_Y103_L0.6090.85
172_R178_L0.6070.85
50_E92_R0.5990.84
132_Q136_R0.5960.83
186_T194_R0.5960.83
99_Y152_L0.5950.83
205_D208_E0.5950.83
12_L16_P0.5920.83
162_Y165_L0.5920.83
123_A134_R0.5870.83
200_W207_L0.5870.83
169_G172_R0.5860.82
109_T129_E0.5780.82
32_D38_E0.5770.81
19_A160_S0.5750.81
117_D122_D0.5740.81
195_V207_L0.5730.81
75_L111_L0.5720.81
50_E93_L0.5710.81
74_F160_S0.5700.81
163_F209_V0.5610.80
63_T77_V0.5610.80
57_E123_A0.5600.80
17_D211_V0.5570.79
173_E182_G0.5540.79
170_E181_D0.5510.78
73_D108_G0.5500.78
162_Y187_L0.5490.78
102_L146_L0.5480.78
45_L49_A0.5440.78
144_E148_R0.5430.77
134_R137_A0.5410.77
22_A164_C0.5410.77
58_W84_A0.5400.77
3_V141_A0.5370.77
198_D203_A0.5360.77
103_L149_N0.5340.76
59_D165_L0.5340.76
196_T205_D0.5340.76
55_W86_W0.5330.76
90_I105_S0.5310.76
31_N36_R0.5310.76
176_V182_G0.5310.76
112_Y165_L0.5300.76
79_L83_L0.5280.75
30_G35_A0.5260.75
89_G104_V0.5250.75
73_D116_Y0.5240.75
74_F165_L0.5230.75
13_I62_P0.5170.74
38_E145_E0.5150.74
64_L216_L0.5140.74
32_D35_A0.5130.73
8_D217_P0.5120.73
177_P182_G0.5100.73
22_A155_F0.5100.73
209_V216_L0.5080.73
144_E147_E0.5060.72
170_E175_E0.5030.72
52_D161_L0.5020.72
53_D57_E0.5020.72
133_A136_R0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ljxA 1 0.422 21 0.951 Contact Map
2dvzA 1 0.6376 18.2 0.952 Contact Map
3m1tA 1 0.5138 17.8 0.953 Contact Map
4r8zA 2 0.6101 15.8 0.954 Contact Map
3tm8A 1 0.4679 15.1 0.954 Contact Map
2qpqA 1 0.6376 13 0.956 Contact Map
2f5xA 1 0.6468 9.2 0.958 Contact Map
3i7aA 1 0.5 9.1 0.959 Contact Map
3memA 1 0.5138 8.5 0.959 Contact Map
3hc1A 1 0.5642 7.5 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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