GREMLIN Database
Nterm_IS4 - Insertion element 4 transposase N-terminal
PFAM: PF13006 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 95 (93)
Sequences: 8186 (4181)
Seq/√Len: 433.6
META: 0.954

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_R95_E2.8721.00
74_S77_A2.6691.00
17_D36_R2.6291.00
22_A92_A2.5181.00
38_V81_A2.4291.00
27_E35_A2.2001.00
81_A84_R2.1841.00
23_T92_A2.0991.00
51_L59_K1.9901.00
21_A26_A1.9831.00
39_V90_L1.9601.00
13_P17_D1.9151.00
77_A80_Q1.8881.00
16_V39_V1.8341.00
45_M53_Y1.8301.00
35_A85_L1.8281.00
76_S80_Q1.8271.00
15_L19_V1.7541.00
79_S83_Q1.7101.00
16_V40_Y1.5871.00
15_L18_E1.5811.00
18_E22_A1.5731.00
33_L38_V1.5331.00
19_V92_A1.4751.00
54_R75_K1.4561.00
57_L78_I1.4171.00
44_A56_V1.4101.00
92_A95_E1.3781.00
41_L53_Y1.3591.00
75_K79_S1.2991.00
6_V9_R1.2881.00
13_P36_R1.2791.00
86_G89_P1.2201.00
51_L55_E1.2121.00
20_L26_A1.2101.00
55_E58_R1.2001.00
74_S80_Q1.1891.00
87_A91_R1.1841.00
38_V41_L1.1701.00
25_R35_A1.1651.00
19_V23_T1.1601.00
39_V85_L1.1271.00
42_V45_M1.1031.00
11_I43_L1.1031.00
41_L45_M1.0891.00
32_R71_R1.0711.00
58_R72_V1.0401.00
76_S79_S1.0211.00
88_E91_R1.0181.00
5_G8_T1.0171.00
48_F59_K1.0041.00
30_R36_R0.9921.00
31_R34_P0.9901.00
39_V93_L0.9581.00
35_A84_R0.9551.00
38_V85_L0.9431.00
20_L35_A0.9321.00
32_R73_P0.9241.00
43_L46_A0.9151.00
3_S6_V0.9131.00
19_V22_A0.8981.00
30_R34_P0.8971.00
23_T89_P0.8851.00
40_Y43_L0.8761.00
38_V42_V0.8661.00
27_E36_R0.8301.00
55_E59_K0.8131.00
27_E30_R0.8081.00
89_P93_L0.8001.00
14_E18_E0.7931.00
41_L78_I0.7901.00
70_W73_P0.7711.00
6_V10_V0.7611.00
73_P77_A0.7541.00
35_A38_V0.7531.00
61_V64_L0.7531.00
3_S8_T0.7521.00
17_D21_A0.7411.00
52_S55_E0.7311.00
20_L27_E0.7291.00
34_P81_A0.7221.00
20_L23_T0.7121.00
46_A53_Y0.7041.00
88_E92_A0.7031.00
89_P92_A0.6991.00
76_S81_A0.6901.00
8_T11_I0.6881.00
46_A49_R0.6711.00
90_L93_L0.6641.00
17_D26_A0.6641.00
57_L62_E0.6540.99
67_L70_W0.6520.99
45_M78_I0.6510.99
57_L72_V0.6510.99
34_P37_V0.6430.99
12_P15_L0.6410.99
7_L43_L0.6400.99
19_V93_L0.6390.99
48_F56_V0.6310.99
28_Q35_A0.6240.99
39_V43_L0.6120.99
63_G66_G0.6090.99
73_P78_I0.6080.99
31_R77_A0.6000.99
55_E75_K0.5980.99
5_G47_L0.5850.99
15_L93_L0.5840.99
44_A47_L0.5830.99
52_S56_V0.5820.99
80_Q83_Q0.5820.99
65_R68_A0.5820.99
49_R55_E0.5800.99
62_E67_L0.5760.99
19_V89_P0.5740.99
25_R88_E0.5740.99
41_L75_K0.5620.98
23_T88_E0.5610.98
13_P40_Y0.5570.98
44_A60_L0.5530.98
15_L49_R0.5520.98
4_L8_T0.5500.98
59_K75_K0.5450.98
83_Q92_A0.5420.98
45_M56_V0.5410.98
28_Q31_R0.5340.98
44_A48_F0.5270.98
54_R73_P0.5270.98
41_L57_L0.5260.98
21_A28_Q0.5250.98
4_L11_I0.5240.98
24_G28_Q0.5240.98
83_Q87_A0.5220.98
33_L78_I0.5180.97
37_V57_L0.5180.97
67_L72_V0.5130.97
50_D53_Y0.5120.97
50_D65_R0.5050.97
54_R72_V0.5040.97
57_L70_W0.5000.97
25_R86_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4d0h0 3 0.3895 4.6 0.906 Contact Map
2q1fA 1 0.4316 3.5 0.911 Contact Map
2eqaA 1 0.5684 3.4 0.912 Contact Map
1vsy5 1 0.8737 3.4 0.912 Contact Map
1pdnC 1 0.8526 3.3 0.912 Contact Map
1k78A 1 0.8842 3 0.915 Contact Map
3p8cB 1 0.2632 2.7 0.916 Contact Map
1k7jA 1 0.5789 2.5 0.918 Contact Map
1p4wA 1 0.7895 2.3 0.92 Contact Map
1yubA 1 0.5263 2.2 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0052 seconds.