GREMLIN Database
DUF3881 - Domain of unknown function, E. rectale Gene description (DUF3881)
PFAM: PF12997 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 283 (283)
Sequences: 700 (534)
Seq/√Len: 31.7
META: 0.79

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_G258_V5.2971.00
243_E262_K5.0941.00
173_A178_D4.8961.00
212_Y226_L4.8271.00
46_E73_Y4.4261.00
234_E262_K4.3591.00
51_I244_I4.1541.00
48_A51_I3.9611.00
2_R264_D3.4801.00
90_H95_S3.4691.00
199_R203_E3.4131.00
234_E243_E3.0581.00
78_G136_T2.9281.00
44_S54_A2.9091.00
236_K241_G2.8171.00
2_R141_S2.7671.00
236_K243_E2.6401.00
76_G136_T2.6021.00
200_I205_V2.5371.00
225_I249_L2.5241.00
177_G181_A2.4220.99
234_E245_Y2.3410.99
8_K263_K2.2350.99
260_I265_L2.2140.99
174_A181_A2.1470.98
232_V271_V2.1220.98
91_A222_Q2.0580.98
89_R94_E1.9800.97
227_G249_L1.9770.97
256_F281_L1.9440.97
90_H97_A1.9300.97
48_A235_V1.8640.96
261_N264_D1.8300.96
150_I207_S1.7750.95
245_Y262_K1.7590.95
38_T58_E1.7500.95
19_L23_I1.7490.95
46_E50_G1.7290.94
174_A177_G1.7270.94
21_D25_N1.7180.94
235_V246_I1.7080.94
99_V108_S1.7040.94
94_E123_K1.6620.93
7_S242_E1.6110.92
74_L246_I1.5630.90
140_L282_Q1.5450.90
152_K210_D1.5130.89
199_R208_I1.5090.89
227_G258_V1.4980.88
74_L259_C1.4930.88
90_H222_Q1.4900.88
18_L49_E1.4890.88
141_S277_G1.4880.88
1_L53_I1.4740.88
113_L119_Y1.4590.87
268_E273_R1.4540.87
27_D45_K1.4100.85
136_T256_F1.4080.85
15_L70_Y1.4010.85
51_I235_V1.4010.85
77_S257_D1.3820.84
212_Y224_S1.3780.84
46_E75_R1.3770.84
163_E206_F1.3600.83
18_L239_L1.3310.82
147_L208_I1.3150.81
78_G257_D1.3030.80
21_D47_F1.3030.80
152_K156_Q1.2950.80
230_L255_I1.2880.79
23_I41_A1.2800.79
19_L67_Y1.2780.79
61_E239_L1.2760.79
123_K150_I1.2760.79
232_V247_M1.2730.79
88_E99_V1.2660.78
170_L181_A1.2500.77
3_A141_S1.2500.77
203_E207_S1.2430.77
173_A176_N1.2430.77
246_I257_D1.2300.76
71_F263_K1.2250.76
30_K121_K1.2200.76
186_T191_D1.2200.76
27_D46_E1.2130.75
267_G274_R1.2070.75
107_V114_Q1.2040.75
216_Y278_N1.2030.75
248_T257_D1.1700.72
20_T64_K1.1690.72
3_A142_L1.1650.72
164_S168_N1.1610.72
76_G257_D1.1580.72
146_I249_L1.1550.71
99_V218_V1.1520.71
34_N38_T1.1480.71
2_R47_F1.1350.70
90_H93_K1.1340.70
109_L211_T1.1230.69
22_V141_S1.1190.69
56_C92_D1.1110.68
203_E208_I1.0980.68
146_I277_G1.0950.67
273_R279_I1.0940.67
208_I226_L1.0920.67
146_I275_F1.0910.67
97_A218_V1.0910.67
4_I140_L1.0890.67
147_L206_F1.0880.67
179_E183_E1.0870.67
74_L257_D1.0850.67
104_R224_S1.0830.66
36_E190_M1.0800.66
90_H198_R1.0760.66
81_S105_V1.0720.66
218_V222_Q1.0710.66
121_K226_L1.0670.65
113_L210_D1.0550.64
46_E245_Y1.0530.64
259_C282_Q1.0440.64
23_I63_D1.0360.63
31_Y39_L1.0320.63
179_E188_E1.0300.63
234_E244_I1.0240.62
95_S112_Y1.0210.62
9_I15_L1.0190.62
276_K280_W1.0190.62
80_S104_R1.0190.62
213_F251_C1.0080.61
90_H112_Y1.0070.61
38_T120_L1.0030.60
57_G65_F1.0010.60
23_I67_Y1.0010.60
80_S254_L0.9960.60
78_G256_F0.9930.60
60_D102_D0.9910.59
28_E75_R0.9810.59
84_D135_V0.9800.59
49_E233_R0.9780.58
260_I264_D0.9780.58
214_M228_E0.9730.58
43_F208_I0.9720.58
18_L62_D0.9710.58
103_I171_I0.9710.58
249_L258_V0.9610.57
274_R283_G0.9590.57
15_L19_L0.9500.56
55_V175_R0.9470.56
101_D188_E0.9420.56
217_G221_D0.9420.56
107_V184_S0.9390.55
92_D95_S0.9380.55
55_V67_Y0.9340.55
52_G57_G0.9340.55
104_R139_G0.9310.55
167_R276_K0.9260.54
69_Y93_K0.9240.54
106_G109_L0.9220.54
154_E158_K0.9200.54
36_E250_E0.9200.54
41_A59_Y0.9190.54
97_A222_Q0.9170.54
244_I249_L0.9120.53
48_A238_S0.9070.53
143_E211_T0.9070.53
152_K228_E0.9010.52
186_T189_D0.9010.52
170_L184_S0.9000.52
97_A214_M0.8990.52
144_G275_F0.8990.52
178_D212_Y0.8930.52
170_L174_A0.8920.52
23_I55_V0.8920.52
167_R193_Y0.8810.51
91_A146_I0.8780.50
61_E93_K0.8660.49
40_L120_L0.8640.49
145_K208_I0.8590.49
8_K164_S0.8510.48
262_K268_E0.8510.48
269_P274_R0.8470.48
260_I275_F0.8460.48
178_D181_A0.8420.47
54_A102_D0.8410.47
170_L276_K0.8400.47
244_I259_C0.8370.47
70_Y186_T0.8370.47
12_R66_H0.8340.47
250_E255_I0.8290.46
45_K73_Y0.8210.46
277_G283_G0.8120.45
231_D248_T0.8090.45
181_A185_L0.8080.45
246_I259_C0.8060.44
19_L70_Y0.8040.44
85_V133_T0.7960.44
40_L116_V0.7930.43
168_N207_S0.7900.43
35_D41_A0.7900.43
267_G272_G0.7880.43
29_R99_V0.7860.43
209_V226_L0.7860.43
242_E261_N0.7830.43
125_L139_G0.7810.42
170_L185_L0.7750.42
46_E249_L0.7740.42
147_L153_D0.7720.42
56_C116_V0.7710.42
187_L191_D0.7710.42
253_D281_L0.7680.41
18_L29_R0.7650.41
126_G241_G0.7640.41
173_A214_M0.7630.41
77_S233_R0.7550.40
118_E132_G0.7540.40
126_G281_L0.7520.40
32_T117_I0.7510.40
188_E245_Y0.7450.40
90_H218_V0.7440.40
270_A273_R0.7430.39
247_M260_I0.7410.39
20_T23_I0.7400.39
247_M272_G0.7380.39
248_T255_I0.7370.39
111_F240_T0.7370.39
108_S196_I0.7340.39
50_G235_V0.7330.39
97_A108_S0.7300.38
10_K168_N0.7230.38
118_E122_E0.7210.38
91_A97_A0.7190.38
43_F59_Y0.7190.38
192_T195_M0.7170.37
118_E201_Q0.7170.37
23_I101_D0.7160.37
274_R277_G0.7160.37
103_I196_I0.7130.37
161_K253_D0.7130.37
90_H183_E0.7050.37
53_I241_G0.7030.36
129_P132_G0.7000.36
99_V187_L0.6960.36
129_P133_T0.6950.36
50_G246_I0.6940.36
158_K161_K0.6930.36
183_E218_V0.6930.36
8_K14_E0.6910.36
265_L275_F0.6900.35
265_L269_P0.6890.35
107_V194_S0.6880.35
74_L102_D0.6870.35
146_I163_E0.6870.35
275_F283_G0.6860.35
141_S275_F0.6830.35
147_L199_R0.6800.35
88_E214_M0.6790.35
167_R171_I0.6790.35
7_S165_K0.6780.35
13_K245_Y0.6780.35
154_E157_K0.6780.35
45_K212_Y0.6780.35
95_S99_V0.6750.34
86_S206_F0.6740.34
96_Y170_L0.6720.34
116_V120_L0.6710.34
146_I271_V0.6700.34
233_R253_D0.6690.34
193_Y273_R0.6690.34
232_V245_Y0.6620.33
214_M218_V0.6600.33
43_F205_V0.6580.33
113_L175_R0.6570.33
50_G60_D0.6560.33
229_I237_N0.6530.33
221_D276_K0.6500.33
221_D280_W0.6490.32
1_L5_G0.6450.32
14_E17_K0.6450.32
42_E56_C0.6430.32
269_P283_G0.6420.32
2_R142_L0.6420.32
82_Y107_V0.6410.32
151_E247_M0.6410.32
230_L236_K0.6400.32
222_Q278_N0.6400.32
189_D197_S0.6390.32
4_I10_K0.6360.32
37_G165_K0.6350.31
205_V276_K0.6320.31
189_D219_E0.6310.31
59_Y65_F0.6300.31
42_E259_C0.6280.31
88_E97_A0.6280.31
40_L117_I0.6280.31
30_K33_S0.6260.31
189_D213_F0.6260.31
141_S261_N0.6240.31
267_G283_G0.6230.31
108_S143_E0.6230.31
273_R276_K0.6210.30
28_E37_G0.6210.30
214_M220_C0.6210.30
10_K207_S0.6200.30
86_S102_D0.6160.30
55_V75_R0.6150.30
119_Y171_I0.6150.30
43_F211_T0.6140.30
87_V132_G0.6130.30
45_K238_S0.6130.30
153_D156_Q0.6120.30
168_N172_A0.6110.30
141_S260_I0.6110.30
155_E192_T0.6070.29
141_S264_D0.6020.29
85_V136_T0.6010.29
8_K62_D0.6010.29
94_E163_E0.6000.29
236_K262_K0.6000.29
220_C228_E0.6000.29
38_T66_H0.6000.29
39_L208_I0.5980.29
166_N169_K0.5960.29
79_I134_S0.5960.29
56_C71_F0.5950.29
139_G171_I0.5910.28
80_S98_G0.5910.28
82_Y184_S0.5880.28
159_K247_M0.5870.28
230_L250_E0.5870.28
70_Y110_I0.5870.28
182_I233_R0.5870.28
112_Y200_I0.5870.28
212_Y281_L0.5840.28
131_K271_V0.5810.28
165_K243_E0.5810.28
176_N206_F0.5810.28
74_L139_G0.5800.28
10_K36_E0.5800.28
252_N273_R0.5800.28
13_K244_I0.5800.28
33_S37_G0.5780.28
69_Y221_D0.5750.27
159_K233_R0.5730.27
40_L56_C0.5730.27
236_K249_L0.5720.27
57_G113_L0.5690.27
87_V123_K0.5690.27
231_D247_M0.5670.27
189_D193_Y0.5660.27
181_A191_D0.5660.27
9_I24_E0.5640.27
96_Y207_S0.5570.26
101_D148_L0.5560.26
56_C107_V0.5550.26
234_E241_G0.5550.26
27_D235_V0.5540.26
258_V263_K0.5530.26
61_E127_K0.5530.26
227_G237_N0.5530.26
83_E261_N0.5520.26
268_E279_I0.5510.26
159_K190_M0.5510.26
191_D194_S0.5500.26
73_Y184_S0.5490.26
76_G193_Y0.5480.26
30_K40_L0.5450.25
171_I251_C0.5430.25
128_L138_S0.5430.25
110_I209_V0.5420.25
110_I252_N0.5410.25
52_G73_Y0.5400.25
167_R189_D0.5390.25
56_C69_Y0.5380.25
146_I224_S0.5380.25
34_N37_G0.5380.25
11_K20_T0.5340.25
4_I53_I0.5340.25
99_V200_I0.5330.25
162_K202_K0.5330.25
16_E116_V0.5320.25
174_A185_L0.5310.25
81_S256_F0.5290.24
96_Y116_V0.5280.24
186_T190_M0.5280.24
88_E93_K0.5260.24
175_R214_M0.5260.24
41_A65_F0.5250.24
16_E19_L0.5240.24
49_E271_V0.5240.24
186_T193_Y0.5230.24
81_S168_N0.5230.24
135_V148_L0.5210.24
44_S139_G0.5210.24
85_V111_F0.5200.24
150_I208_I0.5200.24
15_L250_E0.5180.24
115_N118_E0.5170.24
95_S220_C0.5160.24
89_R152_K0.5160.24
86_S180_E0.5160.24
56_C259_C0.5160.24
101_D212_Y0.5150.24
217_G280_W0.5150.24
232_V239_L0.5140.24
26_P67_Y0.5130.24
108_S217_G0.5130.24
12_R58_E0.5130.24
98_G138_S0.5120.23
76_G156_Q0.5120.23
50_G255_I0.5120.23
11_K142_L0.5110.23
240_T244_I0.5100.23
24_E240_T0.5100.23
4_I77_S0.5090.23
60_D66_H0.5090.23
144_G258_V0.5080.23
2_R98_G0.5070.23
82_Y187_L0.5070.23
217_G276_K0.5050.23
128_L133_T0.5040.23
117_I133_T0.5020.23
107_V252_N0.5020.23
111_F114_Q0.5010.23
51_I114_Q0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zmbA 2 0.3746 25.5 0.969 Contact Map
4upyB 1 0.5053 9.9 0.974 Contact Map
1us0A 1 0.5512 9 0.974 Contact Map
4gieA 1 0.5159 8.7 0.974 Contact Map
4wevX 1 0.5406 7.9 0.975 Contact Map
1vbjA 1 0.4982 7.4 0.975 Contact Map
4gacA 1 0.5618 5.5 0.977 Contact Map
2o3fA 1 0.0883 5.5 0.977 Contact Map
4hbkA 1 0.5194 5.3 0.977 Contact Map
3o0kA 1 0.4452 5.3 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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