GREMLIN Database
DUF3871 - Domain of unknown function, B. Theta Gene description (DUF3871)
PFAM: PF12987 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 319 (310)
Sequences: 687 (488)
Seq/√Len: 27.7
META: 0.859

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_Y201_H8.0881.00
147_K150_E5.7651.00
59_V189_I4.2991.00
133_G155_F4.2701.00
156_I193_F4.2491.00
170_T174_K4.1191.00
136_R141_E3.7121.00
227_L253_A3.6291.00
67_F156_I3.5811.00
93_K102_E3.1581.00
120_T127_R3.0951.00
154_V189_I2.9141.00
154_V177_L2.9131.00
32_H107_Y2.6731.00
49_T136_R2.6670.99
116_I132_I2.6400.99
189_I193_F2.6220.99
154_V192_L2.5210.99
100_E103_K2.5150.99
275_L279_F2.4960.99
219_A257_Y2.4130.99
126_N160_N2.3930.99
214_T217_Q2.3810.99
255_D261_N2.3100.99
28_V32_H2.3040.98
304_G318_F2.2380.98
94_P97_E2.2240.98
271_N274_N2.1650.98
140_L153_K2.1440.98
32_H36_D2.1330.97
255_D263_C2.0940.97
188_K191_E2.0500.97
265_D269_S2.0140.96
141_E151_K1.9550.96
271_N279_F1.9550.96
208_L302_V1.9540.96
272_L302_V1.9270.95
243_L297_N1.9200.95
124_N274_N1.8890.95
244_L279_F1.8810.95
115_E159_K1.8390.94
222_I249_I1.8270.94
91_I136_R1.7910.93
119_I158_F1.7830.93
304_G315_Y1.7320.92
82_P105_I1.7210.92
37_C151_K1.7010.91
37_C91_I1.6960.91
243_L279_F1.6400.89
283_N295_S1.6360.89
160_N164_T1.6050.88
175_S293_D1.5830.88
217_Q309_L1.5810.88
230_Y250_N1.5540.87
244_L248_Q1.5530.87
62_A186_Y1.5360.86
221_L275_L1.5260.86
311_G315_Y1.5160.85
225_M249_I1.5140.85
37_C49_T1.5000.85
137_A140_L1.4950.85
63_A193_F1.4820.84
32_H37_C1.4700.83
37_C136_R1.4630.83
44_K106_Y1.4620.83
41_V46_N1.4570.83
122_T127_R1.4520.83
168_V224_R1.4300.82
247_S250_N1.4270.82
199_E203_H1.4190.81
63_A132_I1.4040.81
120_T129_S1.3590.78
34_K57_E1.3460.78
303_E306_N1.3410.77
222_I264_R1.3380.77
47_E160_N1.3370.77
39_I87_I1.3300.77
255_D281_G1.3290.77
206_E210_N1.2990.75
63_A114_I1.2980.75
100_E147_K1.2820.74
48_L92_H1.2670.73
216_H220_Q1.2660.73
145_S256_Y1.2630.73
44_K108_E1.2570.73
296_V300_E1.2390.71
149_A180_M1.2390.71
227_L257_Y1.2380.71
136_R150_E1.2370.71
240_P304_G1.2360.71
259_D281_G1.2360.71
197_N200_K1.2160.70
225_M242_L1.2120.70
111_A221_L1.2050.69
33_L37_C1.2040.69
95_A102_E1.1970.69
16_S19_P1.1940.69
180_M184_E1.1720.67
286_S290_T1.1600.66
227_L308_A1.1580.66
224_R319_L1.1570.66
127_R161_K1.1470.65
155_F169_S1.1430.65
213_L253_A1.1360.65
58_T305_I1.1360.65
242_L297_N1.1290.64
51_S55_F1.1270.64
126_N255_D1.1260.64
121_E140_L1.1230.64
197_N203_H1.1140.63
211_Y306_N1.0990.62
37_C141_E1.0950.62
213_L309_L1.0820.61
58_T224_R1.0800.61
87_I102_E1.0760.60
240_P250_N1.0740.60
139_N150_E1.0700.60
70_E118_S1.0650.60
121_E206_E1.0650.60
174_K177_L1.0570.59
59_V193_F1.0500.58
67_F193_F1.0350.57
140_L224_R1.0220.56
193_F247_S1.0210.56
110_M236_K1.0190.56
304_G308_A1.0170.56
151_K176_E1.0130.56
221_L301_F1.0070.55
150_E247_S1.0030.55
136_R151_K0.9990.55
62_A66_V0.9990.55
132_I200_K0.9990.55
290_T293_D0.9920.54
66_V69_G0.9920.54
128_L170_T0.9890.54
97_E101_H0.9880.54
115_E131_T0.9860.54
244_L298_A0.9850.54
84_K106_Y0.9810.53
261_N274_N0.9720.53
46_N106_Y0.9710.52
103_K154_V0.9700.52
92_H136_R0.9590.52
316_S319_L0.9580.51
89_E102_E0.9560.51
263_C271_N0.9520.51
181_S184_E0.9510.51
226_R250_N0.9470.51
300_E303_E0.9450.50
224_R239_L0.9450.50
307_K311_G0.9410.50
242_L301_F0.9360.50
128_L160_N0.9340.50
32_H105_I0.9320.49
55_F134_G0.9240.49
66_V193_F0.9230.49
49_T150_E0.9170.48
55_F152_F0.9120.48
48_L54_E0.9110.48
28_V79_V0.9030.47
164_T174_K0.8990.47
42_F45_D0.8940.47
39_I48_L0.8940.47
173_Y293_D0.8920.46
43_S136_R0.8910.46
261_N264_R0.8910.46
73_L115_E0.8900.46
235_E238_E0.8840.46
151_K155_F0.8840.46
58_T182_T0.8830.46
42_F49_T0.8820.46
179_V185_L0.8810.46
263_C274_N0.8810.46
299_T304_G0.8800.46
48_L102_E0.8780.45
16_S73_L0.8740.45
228_Y240_P0.8740.45
167_C276_Y0.8720.45
31_E35_N0.8710.45
146_K205_M0.8700.45
51_S115_E0.8680.45
203_H206_E0.8670.45
300_E318_F0.8660.44
37_C48_L0.8620.44
142_N160_N0.8620.44
59_V63_A0.8600.44
137_A308_A0.8580.44
42_F253_A0.8570.44
220_Q227_L0.8560.44
47_E52_H0.8560.44
113_V131_T0.8540.44
102_E248_Q0.8530.43
19_P159_K0.8520.43
83_I137_A0.8510.43
92_H168_V0.8510.43
233_K237_K0.8490.43
39_I224_R0.8470.43
276_Y280_T0.8460.43
82_P91_I0.8450.43
48_L51_S0.8440.43
153_K166_L0.8440.43
164_T281_G0.8440.43
243_L271_N0.8420.43
113_V166_L0.8400.43
63_A118_S0.8370.42
71_T118_S0.8320.42
97_E188_K0.8310.42
33_L53_Q0.8300.42
89_E93_K0.8300.42
48_L136_R0.8290.42
295_S301_F0.8260.41
69_G205_M0.8260.41
62_A190_L0.8240.41
247_S252_V0.8240.41
110_M220_Q0.8180.41
264_R268_G0.8110.40
15_S132_I0.8070.40
161_K169_S0.8070.40
51_S70_E0.8060.40
65_D197_N0.8050.40
31_E43_S0.8000.40
280_T283_N0.7970.39
32_H82_P0.7940.39
76_E136_R0.7940.39
272_L279_F0.7920.39
37_C82_P0.7890.39
113_V159_K0.7850.38
191_E197_N0.7840.38
31_E36_D0.7830.38
302_V308_A0.7830.38
225_M244_L0.7790.38
75_P117_P0.7770.38
189_I221_L0.7770.38
69_G224_R0.7770.38
227_L275_L0.7750.38
279_F302_V0.7720.38
204_L299_T0.7670.37
133_G169_S0.7650.37
222_I253_A0.7640.37
123_I151_K0.7630.37
240_P297_N0.7630.37
240_P315_Y0.7600.37
177_L187_Q0.7600.37
134_G152_F0.7600.37
261_N269_S0.7590.37
270_I278_L0.7590.37
88_P107_Y0.7580.37
100_E120_T0.7560.36
208_L291_F0.7550.36
261_N300_E0.7530.36
168_V293_D0.7500.36
49_T138_Y0.7440.36
96_K203_H0.7430.35
275_L302_V0.7420.35
66_V77_I0.7410.35
307_K314_E0.7390.35
224_R290_T0.7380.35
117_P205_M0.7380.35
42_F138_Y0.7350.35
248_Q285_S0.7350.35
56_I114_I0.7340.35
139_N144_Y0.7330.35
129_S132_I0.7310.35
227_L318_F0.7300.35
113_V155_F0.7300.35
192_L195_N0.7290.35
170_T226_R0.7270.34
304_G316_S0.7260.34
41_V106_Y0.7230.34
20_F24_N0.7220.34
106_Y159_K0.7210.34
87_I101_H0.7210.34
283_N286_S0.7200.34
148_S179_V0.7190.34
257_Y264_R0.7180.34
52_H136_R0.7180.34
191_E200_K0.7120.33
16_S31_E0.7100.33
181_S296_V0.7090.33
16_S76_E0.7060.33
168_V174_K0.7040.33
304_G310_N0.7010.33
226_R230_Y0.7000.33
279_F282_A0.6990.32
136_R144_Y0.6990.32
60_Q64_S0.6970.32
131_T159_K0.6950.32
46_N51_S0.6930.32
126_N274_N0.6900.32
159_K164_T0.6870.32
49_T91_I0.6830.31
212_S225_M0.6820.31
183_A241_P0.6810.31
113_V133_G0.6790.31
252_V283_N0.6750.31
222_I290_T0.6720.31
17_S22_E0.6650.30
250_N281_G0.6640.30
30_L222_I0.6620.30
159_K170_T0.6590.30
235_E271_N0.6550.30
76_E250_N0.6540.30
136_R169_S0.6540.30
129_S193_F0.6530.29
43_S282_A0.6510.29
190_L194_Q0.6510.29
83_I100_E0.6480.29
124_N184_E0.6470.29
282_A286_S0.6450.29
140_L293_D0.6450.29
91_I151_K0.6430.29
94_P100_E0.6430.29
20_F25_T0.6430.29
198_A203_H0.6420.29
49_T147_K0.6420.29
141_E164_T0.6380.29
137_A166_L0.6350.28
58_T186_Y0.6340.28
312_D315_Y0.6340.28
155_F168_V0.6330.28
91_I141_E0.6320.28
177_L188_K0.6320.28
41_V44_K0.6300.28
19_P113_V0.6280.28
120_T205_M0.6280.28
94_P226_R0.6270.28
133_G153_K0.6270.28
204_L236_K0.6250.28
63_A83_I0.6240.28
161_K164_T0.6230.28
220_Q308_A0.6230.28
87_I120_T0.6230.28
306_N319_L0.6210.27
49_T169_S0.6200.27
52_H160_N0.6190.27
123_I128_L0.6190.27
245_T272_L0.6190.27
44_K147_K0.6180.27
123_I166_L0.6160.27
115_E129_S0.6140.27
54_E102_E0.6120.27
267_D319_L0.6120.27
149_A179_V0.6100.27
170_T192_L0.6090.27
69_G164_T0.6090.27
307_K310_N0.6090.27
140_L144_Y0.6070.27
195_N266_E0.6070.27
154_V193_F0.6040.26
213_L275_L0.6040.26
79_V168_V0.6020.26
100_E173_Y0.6010.26
214_T228_Y0.6000.26
239_L318_F0.6000.26
205_M275_L0.6000.26
59_V62_A0.5970.26
48_L91_I0.5970.26
311_G316_S0.5970.26
47_E150_E0.5970.26
70_E295_S0.5960.26
160_N255_D0.5940.26
224_R244_L0.5920.26
207_Q210_N0.5920.26
66_V189_I0.5900.26
160_N196_Y0.5890.26
82_P245_T0.5890.26
198_A290_T0.5880.26
188_K251_T0.5860.25
102_E230_Y0.5840.25
150_E229_Q0.5830.25
136_R147_K0.5820.25
33_L36_D0.5820.25
84_K108_E0.5790.25
221_L244_L0.5780.25
90_A104_T0.5770.25
255_D271_N0.5760.25
46_N167_C0.5750.25
15_S76_E0.5740.25
257_Y275_L0.5740.25
289_D294_R0.5730.25
308_A315_Y0.5720.25
169_S200_K0.5720.25
19_P27_E0.5670.24
191_E195_N0.5650.24
49_T141_E0.5650.24
70_E180_M0.5640.24
99_L256_Y0.5640.24
120_T260_E0.5640.24
87_I176_E0.5630.24
233_K236_K0.5620.24
153_K169_S0.5600.24
211_Y310_N0.5600.24
284_K287_Y0.5600.24
58_T314_E0.5590.24
53_Q240_P0.5580.24
226_R246_D0.5580.24
187_Q194_Q0.5570.24
92_H253_A0.5570.24
281_G295_S0.5550.24
235_E239_L0.5550.24
33_L306_N0.5540.24
195_N270_I0.5520.23
59_V116_I0.5520.23
94_P175_S0.5520.23
105_I177_L0.5510.23
245_T271_N0.5490.23
156_I271_N0.5490.23
226_R241_P0.5480.23
256_Y264_R0.5470.23
34_K285_S0.5470.23
251_T254_K0.5460.23
141_E178_R0.5460.23
257_Y280_T0.5450.23
304_G312_D0.5430.23
48_L52_H0.5410.23
141_E150_E0.5400.23
156_I252_V0.5370.23
251_T301_F0.5350.23
263_C281_G0.5350.23
79_V111_A0.5340.23
34_K129_S0.5330.22
22_E276_Y0.5330.22
213_L217_Q0.5330.22
110_M160_N0.5310.22
203_H209_S0.5300.22
30_L208_L0.5290.22
260_E281_G0.5280.22
23_A47_E0.5280.22
222_I263_C0.5270.22
38_I139_N0.5270.22
204_L207_Q0.5260.22
187_Q191_E0.5250.22
249_I265_D0.5250.22
248_Q290_T0.5240.22
118_S295_S0.5240.22
105_I131_T0.5230.22
160_N281_G0.5230.22
110_M159_K0.5230.22
101_H247_S0.5220.22
46_N88_P0.5210.22
36_D42_F0.5210.22
77_I302_V0.5200.22
146_K168_V0.5190.22
177_L242_L0.5190.22
30_L180_M0.5180.22
111_A173_Y0.5170.22
249_I276_Y0.5170.22
168_V229_Q0.5150.22
26_K161_K0.5140.21
236_K276_Y0.5130.21
260_E263_C0.5110.21
200_K203_H0.5080.21
310_N316_S0.5080.21
49_T139_N0.5080.21
30_L53_Q0.5070.21
301_F306_N0.5070.21
93_K112_F0.5070.21
82_P151_K0.5050.21
232_P265_D0.5040.21
263_C269_S0.5030.21
37_C52_H0.5030.21
89_E108_E0.5020.21
87_I93_K0.5010.21
22_E76_E0.5010.21
99_L254_K0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l4hA 1 0.5266 32.3 0.979 Contact Map
2huoA 1 0.232 30.9 0.979 Contact Map
1lm7A 2 0.163 22.5 0.98 Contact Map
2b1uA 1 0.2226 19.7 0.981 Contact Map
1exrA 1 0.4545 18.6 0.981 Contact Map
2m8uA 1 0.2414 17.3 0.981 Contact Map
2jnfA 1 0.4639 15.1 0.982 Contact Map
4mzjA 1 0.3793 13.9 0.982 Contact Map
1y1xA 2 0.5486 11.9 0.982 Contact Map
1cb1A 1 0.2445 11.6 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.