GREMLIN Database
DUF3870 - Domain of unknown function (DUF3870)
PFAM: PF12986 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 94 (93)
Sequences: 1067 (825)
Seq/√Len: 85.6
META: 0.717

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_L89_A3.0761.00
16_E19_K2.7441.00
27_V59_L2.4861.00
57_Y69_E2.4381.00
48_D52_S2.3641.00
88_D91_K2.3471.00
36_D51_R2.2161.00
1_Y24_G2.1701.00
67_I83_I2.1441.00
29_R72_R2.0761.00
26_E52_S1.9141.00
58_N61_D1.8461.00
44_E48_D1.7931.00
38_S45_L1.7621.00
63_I90_Y1.7421.00
66_I86_L1.7301.00
32_G58_N1.7211.00
57_Y66_I1.7041.00
28_D35_V1.5851.00
54_L86_L1.5701.00
28_D33_V1.5601.00
32_G93_Y1.5271.00
68_E71_E1.4620.99
67_I71_E1.4600.99
11_G16_E1.4280.99
43_T46_T1.4260.99
44_E47_R1.3890.99
38_S47_R1.3840.99
36_D48_D1.3140.99
62_G90_Y1.3130.99
49_F73_R1.2970.99
8_L14_A1.2620.98
65_E68_E1.2530.98
62_G66_I1.2330.98
69_E73_R1.2270.98
62_G65_E1.1950.97
33_V58_N1.1830.97
5_Y22_G1.1760.97
57_Y62_G1.1630.97
49_F53_L1.1170.96
39_C50_V1.1120.96
13_A20_V1.0990.96
57_Y65_E1.0900.96
61_D65_E1.0830.95
41_L46_T1.0790.95
26_E35_V1.0720.95
22_G40_T1.0620.95
33_V56_G1.0480.95
40_T43_T1.0090.93
29_R73_R0.9960.93
54_L74_Y0.9710.92
13_A22_G0.9480.91
50_V86_L0.9470.91
71_E79_Q0.9230.90
50_V54_L0.9020.89
5_Y13_A0.9010.89
22_G78_S0.8930.88
38_S44_E0.8920.88
36_D55_V0.8890.88
13_A92_K0.8690.87
30_E33_V0.8430.85
12_N78_S0.8400.85
63_I86_L0.8360.85
84_V88_D0.8040.82
30_E61_D0.8030.82
43_T47_R0.7960.82
64_E68_E0.7930.82
5_Y43_T0.7920.81
70_I79_Q0.7880.81
34_I59_L0.7840.81
25_L82_L0.7830.81
39_C76_G0.7790.80
70_I82_L0.7790.80
34_I62_G0.7730.80
54_L66_I0.7710.80
4_G88_D0.7680.79
12_N41_L0.7660.79
6_A32_G0.7640.79
14_A21_F0.7540.78
78_S81_A0.7530.78
67_I70_I0.7520.78
68_E72_R0.7390.77
10_Q74_Y0.7290.76
2_I25_L0.7270.76
3_T24_G0.7210.75
84_V87_K0.7200.75
6_A67_I0.7100.74
3_T89_A0.7070.74
14_A78_S0.7060.73
21_F77_S0.6960.72
63_I67_I0.6840.71
8_L15_T0.6770.70
59_L90_Y0.6720.70
30_E69_E0.6720.70
50_V82_L0.6640.69
26_E36_D0.6620.69
8_L12_N0.6600.68
14_A22_G0.6600.68
19_K69_E0.6470.67
8_L81_A0.6460.67
70_I86_L0.6400.66
60_L90_Y0.6390.66
18_Y74_Y0.6390.66
40_T91_K0.6360.65
12_N77_S0.6320.65
87_K92_K0.6290.65
27_V75_F0.6290.65
38_S74_Y0.6220.64
29_R32_G0.6190.63
68_E90_Y0.6160.63
60_L66_I0.6150.63
71_E80_K0.5980.61
86_L90_Y0.5940.60
81_A85_A0.5940.60
15_T19_K0.5930.60
48_D51_R0.5840.59
5_Y40_T0.5830.59
56_G64_E0.5790.58
11_G43_T0.5790.58
22_G77_S0.5710.57
64_E67_I0.5650.56
53_L69_E0.5640.56
77_S88_D0.5620.56
5_Y12_N0.5540.55
51_R72_R0.5490.54
31_T58_N0.5480.54
13_A76_G0.5450.54
76_G87_K0.5450.54
39_C43_T0.5320.52
30_E51_R0.5310.52
59_L74_Y0.5270.51
35_V52_S0.5180.50
52_S55_V0.5160.50
32_G60_L0.5160.50
46_T89_A0.5150.50
75_F79_Q0.5140.50
83_I93_Y0.5070.49
17_V20_V0.5040.48
55_V84_V0.5010.48
8_L78_S0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z7eA 5 1 47.8 0.873 Contact Map
3r07C 1 0.8298 32.2 0.885 Contact Map
1su0B 1 0.9468 32.1 0.885 Contact Map
3fxgA 5 0.9894 30.2 0.887 Contact Map
4kn9L 2 0.7872 27.2 0.889 Contact Map
4eb5C 1 0.9787 23.3 0.893 Contact Map
3i6eA 4 0.8936 21.8 0.894 Contact Map
1xjsA 1 0.9681 21.4 0.894 Contact Map
1e3dB 1 0.8511 20.8 0.895 Contact Map
3i4kA 4 0.9894 19.5 0.896 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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