GREMLIN Database
DUF3868 - Domain of unknown function, B. Theta Gene description (DUF3868)
PFAM: PF12984 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 110 (95)
Sequences: 874 (760)
Seq/√Len: 77.9
META: 0.833

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_V78_L4.6081.00
84_N89_Y4.4851.00
84_N92_Y3.4731.00
50_I81_V3.2061.00
60_N87_N2.9641.00
62_S84_N2.9251.00
20_A23_Q2.4001.00
34_N49_D2.3821.00
32_V48_M1.9091.00
32_V50_I1.8531.00
62_S92_Y1.8411.00
86_R90_K1.7751.00
13_L16_S1.7681.00
64_T82_V1.7651.00
90_K93_E1.7081.00
6_I9_L1.6851.00
62_S66_T1.5310.99
45_Y57_V1.4750.99
69_L78_L1.3890.99
62_S82_V1.3860.99
89_Y93_E1.3850.99
8_L12_L1.2580.97
59_S86_R1.2560.97
82_V92_Y1.2050.97
7_L16_S1.2010.97
58_K61_R1.1930.97
87_N90_K1.1900.96
52_L83_I1.1850.96
88_R91_A1.1640.96
48_M92_Y1.1630.96
10_L16_S1.1480.96
65_L81_V1.1400.96
46_V69_L1.1200.95
50_I65_L1.0990.95
90_K98_L1.0930.94
91_A95_N1.0900.94
71_S75_S1.0790.94
92_Y95_N1.0480.93
52_L81_V1.0420.93
73_D76_L1.0410.93
19_A23_Q1.0270.92
16_S21_Q1.0060.91
14_C54_G0.9930.91
36_S68_V0.9880.91
44_L62_S0.9790.90
30_I51_D0.9780.90
37_V40_Q0.9650.90
26_Y29_Q0.9650.90
68_V75_S0.9520.89
51_D55_L0.9410.88
9_L81_V0.9410.88
44_L48_M0.9310.88
44_L69_L0.9240.88
8_L15_L0.9090.87
62_S88_R0.9060.87
89_Y92_Y0.9000.86
90_K95_N0.8990.86
6_I14_C0.8900.86
53_S83_I0.8680.84
32_V99_N0.8520.83
9_L27_K0.8450.82
41_G82_V0.8420.82
25_S30_I0.8420.82
7_L13_L0.8410.82
35_V62_S0.8390.82
51_D93_E0.8280.81
52_L55_L0.8260.81
5_F8_L0.8250.81
33_E51_D0.8150.80
93_E97_A0.7900.78
59_S72_G0.7810.77
70_V77_E0.7690.76
7_L63_L0.7650.76
8_L16_S0.7560.75
59_S87_N0.7470.74
44_L79_P0.7450.74
44_L70_V0.7400.73
52_L91_A0.7390.73
40_Q45_Y0.7370.73
12_L19_A0.7360.73
14_C29_Q0.7330.73
53_S88_R0.7290.72
26_Y58_K0.7240.72
28_G54_G0.7210.71
84_N88_R0.7130.71
44_L65_L0.7130.71
19_A69_L0.7100.70
61_R93_E0.7090.70
39_R60_N0.7000.69
36_S83_I0.6870.68
12_L21_Q0.6860.68
28_G64_T0.6800.67
49_D77_E0.6800.67
15_L20_A0.6750.66
52_L62_S0.6720.66
33_E40_Q0.6710.66
40_Q43_S0.6670.65
82_V90_K0.6660.65
14_C19_A0.6630.65
73_D90_K0.6430.63
7_L15_L0.6430.63
9_L14_C0.6370.62
32_V65_L0.6360.62
5_F15_L0.6350.62
19_A22_A0.6290.61
6_I16_S0.6280.61
87_N91_A0.6230.60
66_T80_P0.6150.59
60_N91_A0.6140.59
67_P78_L0.6120.59
34_N98_L0.6050.58
18_G22_A0.6020.58
92_Y96_L0.5980.57
80_P93_E0.5970.57
13_L72_G0.5920.56
31_S39_R0.5890.56
6_I12_L0.5760.54
63_L84_N0.5750.54
70_V74_G0.5750.54
20_A71_S0.5720.54
72_G76_L0.5720.54
11_L21_Q0.5660.53
35_V90_K0.5610.52
51_D97_A0.5570.52
43_S73_D0.5570.52
73_D83_I0.5560.52
39_R89_Y0.5540.51
15_L18_G0.5510.51
70_V75_S0.5340.49
35_V48_M0.5320.49
9_L21_Q0.5310.49
86_R89_Y0.5300.48
18_G58_K0.5280.48
66_T99_N0.5270.48
24_T81_V0.5230.47
11_L54_G0.5210.47
51_D86_R0.5190.47
37_V60_N0.5160.47
32_V38_E0.5120.46
35_V57_V0.5050.45
71_S93_E0.5040.45
47_D91_A0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w9xA 2 0.7091 19.6 0.89 Contact Map
4uu4A 1 0.7182 19.3 0.891 Contact Map
3zbiC 1 0.2545 9.7 0.904 Contact Map
4ncdA 2 0.6818 7.8 0.908 Contact Map
1y0gA 2 0.6545 7.7 0.908 Contact Map
1dbgA 1 0.6636 7.2 0.909 Contact Map
2qn4A 1 0.5818 7 0.91 Contact Map
2c0nA 2 0.4273 6.8 0.911 Contact Map
3j46n 1 0.7818 5.4 0.915 Contact Map
1kmoA 1 0.2818 5.3 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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