GREMLIN Database
DUF3848 - Protein of unknown function (DUF3848)
PFAM: PF12959 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 95 (91)
Sequences: 912 (730)
Seq/√Len: 76.5
META: 0.934

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_E38_K3.2191.00
25_P28_I2.9151.00
21_L26_E2.4811.00
9_M42_L2.4361.00
13_Q17_R2.4291.00
29_L35_I2.3791.00
13_Q38_K2.1621.00
61_S67_D2.0981.00
19_W23_Q2.0591.00
31_H34_E1.9311.00
17_R21_L1.9251.00
21_L29_L1.9131.00
66_A70_D1.8661.00
23_Q31_H1.8431.00
17_R29_L1.8051.00
20_L29_L1.7151.00
54_Q92_D1.6611.00
73_L76_D1.6191.00
23_Q27_E1.5340.99
9_M45_L1.5310.99
26_E30_D1.5140.99
32_A36_T1.4990.99
40_D80_M1.4990.99
2_N55_A1.4390.99
72_W75_R1.3840.99
63_N66_A1.3740.99
38_K66_A1.3580.98
11_A15_D1.3480.98
10_E14_E1.3430.98
33_Y72_W1.2890.98
16_F35_I1.2710.98
41_I68_L1.2560.97
24_P27_E1.2560.97
5_L55_A1.2510.97
9_M64_P1.2490.97
3_T7_E1.2470.97
37_V79_H1.2410.97
85_D89_D1.2400.97
20_L35_I1.2000.96
32_A35_I1.1750.96
81_D84_R1.1020.94
22_S26_E1.0900.94
41_I69_Y1.0510.93
61_S64_P1.0510.93
75_R89_D1.0460.93
50_L54_Q1.0420.92
13_Q35_I1.0380.92
41_I83_L1.0140.91
84_R88_E0.9650.89
72_W86_S0.9640.89
72_W78_S0.9340.88
89_D92_D0.9270.87
43_M46_E0.9220.87
20_L31_H0.9220.87
16_F36_T0.9140.86
71_E90_R0.9100.86
57_A61_S0.9030.86
11_A18_D0.8980.86
16_F20_L0.8780.84
52_D56_K0.8600.83
38_K69_Y0.8400.81
17_R35_I0.8390.81
14_E17_R0.8310.81
33_Y69_Y0.8040.79
40_D79_H0.7830.77
63_N67_D0.7820.77
70_D73_L0.7760.76
19_W31_H0.7740.76
78_S82_D0.7690.75
48_N54_Q0.7640.75
75_R86_S0.7640.75
2_N6_Y0.7590.74
38_K42_L0.7520.74
19_W28_I0.7480.73
45_L48_N0.7460.73
5_L59_L0.7350.72
9_M59_L0.7320.72
20_L28_I0.7270.71
68_L87_I0.7260.71
51_S92_D0.7250.71
2_N8_K0.7190.70
86_S90_R0.7160.70
69_Y73_L0.7110.70
15_D19_W0.7050.69
16_F19_W0.6940.68
71_E74_D0.6870.67
7_E11_A0.6820.66
83_L86_S0.6790.66
12_E69_Y0.6700.65
12_E57_A0.6690.65
78_S83_L0.6630.64
12_E63_N0.6590.64
4_K59_L0.6500.63
67_D90_R0.6470.62
8_K33_Y0.6380.61
85_D88_E0.6310.60
68_L90_R0.6280.60
84_R87_I0.6240.60
6_Y42_L0.6110.58
3_T10_E0.6080.58
28_I39_E0.6060.57
10_E13_Q0.6050.57
4_K7_E0.6040.57
86_S89_D0.6030.57
18_D21_L0.5940.56
8_K86_S0.5940.56
52_D60_K0.5850.55
74_D81_D0.5850.55
75_R85_D0.5840.55
33_Y76_D0.5820.54
5_L64_P0.5780.54
66_A69_Y0.5730.53
82_D86_S0.5690.53
8_K62_P0.5640.52
28_I31_H0.5620.52
80_M83_L0.5610.52
53_E92_D0.5610.52
15_D37_V0.5580.51
11_A14_E0.5560.51
22_S27_E0.5490.50
24_P57_A0.5470.50
6_Y10_E0.5440.49
74_D77_T0.5420.49
12_E61_S0.5400.49
16_F55_A0.5390.49
84_R91_A0.5310.48
22_S30_D0.5300.48
15_D27_E0.5270.47
33_Y37_V0.5230.47
44_A83_L0.5190.46
17_R26_E0.5110.45
16_F37_V0.5100.45
20_L39_E0.5080.45
45_L75_R0.5010.44
51_S56_K0.5010.44
72_W82_D0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o3lA 1 0.7895 19.6 0.872 Contact Map
2hh6A 2 0.8947 9.4 0.888 Contact Map
4jrbA 1 0.6632 6.4 0.897 Contact Map
3fxbA 1 0.9158 5.3 0.901 Contact Map
2o4tA 2 0.7368 5 0.902 Contact Map
4pfiA 1 0.9053 4.6 0.904 Contact Map
4n4uA 1 0.9474 4.5 0.904 Contact Map
4o94A 1 0.9368 4.2 0.905 Contact Map
3rh3A 1 0.9263 3.6 0.908 Contact Map
4pe3A 1 0.9579 3.6 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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