GREMLIN Database
DUF3847 - Protein of unknown function (DUF3847)
PFAM: PF12958 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 84 (76)
Sequences: 1215 (836)
Seq/√Len: 95.9
META: 0.902

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_I50_A2.9851.00
19_L23_L2.7901.00
49_G52_L2.4151.00
52_L67_F2.4101.00
42_T46_I2.2451.00
54_S68_K2.2331.00
47_E64_D2.1351.00
20_E23_L2.0391.00
18_Q21_N2.0101.00
33_L40_A1.9241.00
51_I68_K1.8161.00
21_N24_K1.7411.00
79_E82_E1.7331.00
43_H47_E1.7171.00
44_R53_E1.6341.00
68_K72_E1.6261.00
41_R45_L1.5501.00
48_R64_D1.5131.00
14_E17_E1.5121.00
63_T66_Q1.5021.00
77_T80_A1.4511.00
22_R25_R1.4471.00
51_I55_L1.3170.99
47_E51_I1.2790.99
13_E16_I1.2670.99
27_E31_K1.2500.99
48_R67_F1.2210.98
58_E61_T1.1980.98
52_L71_L1.1710.98
25_R29_R1.1430.98
51_I64_D1.1290.97
14_E18_Q1.1140.97
5_L9_I1.1050.97
42_T45_L1.0790.97
27_E30_Q1.0650.96
59_T62_L1.0450.96
70_F74_T1.0440.96
15_K19_L1.0400.96
12_A15_K1.0260.96
39_K42_T1.0150.95
16_I23_L1.0020.95
74_T80_A0.9950.95
57_P60_I0.9820.94
43_H49_G0.9350.93
12_A16_I0.9150.92
19_L22_R0.9130.92
23_L27_E0.9060.92
15_K23_L0.8730.90
11_K15_K0.8580.89
32_E39_K0.8530.89
17_E21_N0.8520.89
30_Q34_E0.8460.89
55_L72_E0.8190.87
6_E9_I0.8110.86
26_L30_Q0.8050.86
78_P82_E0.8020.86
74_T79_E0.8020.86
62_L67_F0.8010.86
46_I49_G0.7960.85
16_I19_L0.7950.85
45_L60_I0.7900.85
10_E13_E0.7720.84
67_F71_L0.7640.83
34_E38_R0.7580.82
72_E76_A0.7570.82
52_L59_T0.7540.82
80_A83_I0.7530.82
15_K22_R0.7410.81
28_N31_K0.7360.81
23_L31_K0.7140.78
79_E83_I0.7090.78
9_I13_E0.7050.78
20_E24_K0.7040.78
24_K28_N0.6980.77
12_A19_L0.6940.76
75_F80_A0.6800.75
18_Q34_E0.6750.75
73_K76_A0.6700.74
11_K14_E0.6630.73
56_L59_T0.6610.73
15_K18_Q0.6610.73
55_L68_K0.6490.72
18_Q22_R0.6470.71
15_K27_E0.6470.71
48_R53_E0.6260.69
49_G75_F0.6190.68
44_R48_R0.6080.67
27_E34_E0.6010.66
76_A80_A0.6000.66
74_T77_T0.6000.66
78_P81_R0.5970.65
58_E62_L0.5940.65
46_I51_I0.5910.64
11_K19_L0.5870.64
68_K71_L0.5760.62
25_R28_N0.5750.62
55_L75_F0.5570.60
12_A23_L0.5560.60
43_H46_I0.5530.59
64_D68_K0.5410.58
41_R50_A0.5410.58
28_N33_L0.5350.57
8_E11_K0.5340.57
16_I20_E0.5330.57
13_E20_E0.5300.56
69_A73_K0.5300.56
5_L12_A0.5290.56
73_K83_I0.5250.55
49_G59_T0.5200.55
17_E20_E0.5190.55
26_L29_R0.5140.54
10_E14_E0.5090.53
56_L75_F0.5050.53
48_R51_I0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q4gX 1 0 46.7 0.853 Contact Map
1vw1A 5 0.9405 38.1 0.861 Contact Map
4aniA 2 0.9405 37 0.862 Contact Map
4cgkA 3 0.9524 35 0.863 Contact Map
3a6mA 2 1 19.8 0.879 Contact Map
2yxyA 1 0.8333 18.9 0.88 Contact Map
2akfA 3 0.381 16.7 0.883 Contact Map
3errA 2 1 16.1 0.884 Contact Map
3hnwA 2 0.4762 15.3 0.885 Contact Map
4rsiA 1 0 14.1 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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