GREMLIN Database
DUF3846 - Domain of unknown function (DUF3846)
PFAM: PF12957 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (88)
Sequences: 4121 (3434)
Seq/√Len: 366.1
META: 0.94

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_K66_D2.9301.00
45_N51_K2.7631.00
45_N53_L2.4291.00
47_E50_L2.3731.00
19_L23_Q2.3581.00
43_V84_F2.3441.00
31_E46_E2.0461.00
3_V25_A1.8901.00
32_A41_A1.8481.00
18_T21_A1.6921.00
43_V75_V1.6701.00
6_P71_T1.6591.00
4_V72_F1.6321.00
5_E8_K1.6301.00
42_L72_F1.6021.00
3_V13_V1.5801.00
47_E51_K1.5531.00
22_L73_F1.5511.00
78_D85_T1.5201.00
5_E71_T1.5061.00
19_L30_I1.5031.00
53_L71_T1.4811.00
49_K69_V1.4771.00
29_Y46_E1.4661.00
44_C48_G1.4571.00
42_L68_I1.4541.00
5_E11_E1.4051.00
13_V25_A1.3481.00
16_E21_A1.3341.00
26_V45_N1.2811.00
3_V71_T1.2791.00
68_I72_F1.2781.00
42_L74_I1.2221.00
49_K67_I1.2111.00
32_A43_V1.2071.00
3_V11_E1.2041.00
23_Q26_V1.1681.00
44_C72_F1.1601.00
32_A46_E1.1571.00
40_V74_I1.1541.00
48_G69_V1.1531.00
75_V84_F1.1461.00
40_V76_G1.1371.00
41_A77_L1.1331.00
32_A84_F1.1031.00
21_A24_K1.0761.00
21_A25_A1.0691.00
77_L85_T1.0671.00
20_E23_Q1.0651.00
76_G88_T1.0551.00
25_A73_F1.0311.00
57_R72_F1.0121.00
43_V73_F1.0101.00
58_A61_D1.0021.00
23_Q28_G0.9941.00
29_Y47_E0.9781.00
4_V74_I0.9691.00
55_L69_V0.9281.00
28_G31_E0.9271.00
30_I43_V0.9131.00
41_A84_F0.9111.00
55_L67_I0.9111.00
15_I25_A0.9101.00
76_G85_T0.9101.00
62_G65_Y0.8721.00
5_E9_E0.8591.00
23_Q30_I0.8581.00
4_V57_R0.8351.00
20_E24_K0.8281.00
22_L30_I0.8171.00
23_Q29_Y0.8111.00
28_G45_N0.8021.00
27_G71_T0.7971.00
15_I21_A0.7941.00
78_D82_G0.7851.00
58_A64_I0.7661.00
79_D82_G0.7281.00
27_G51_K0.7040.99
7_G10_P0.7010.99
48_G53_L0.7000.99
2_L10_P0.6990.99
5_E10_P0.6970.99
79_D83_D0.6920.99
17_N21_A0.6900.99
78_D83_D0.6670.99
31_E44_C0.6660.99
4_V8_K0.6620.99
33_V44_C0.6530.99
19_L22_L0.6510.99
59_L72_F0.6380.99
33_V68_I0.6320.99
2_L87_L0.6300.99
31_E45_N0.6270.99
60_G64_I0.6200.99
56_N69_V0.6060.98
7_G54_P0.6050.98
40_V87_L0.6040.98
35_P41_A0.6030.98
27_G45_N0.6020.98
3_V73_F0.5760.98
28_G32_A0.5750.98
33_V42_L0.5750.98
77_L83_D0.5750.98
50_L69_V0.5740.98
8_K11_E0.5730.98
14_E86_S0.5700.98
22_L25_A0.5700.98
23_Q45_N0.5630.97
26_V73_F0.5620.97
44_C49_K0.5620.97
44_C68_I0.5580.97
19_L31_E0.5540.97
13_V73_F0.5530.97
26_V71_T0.5510.97
79_D85_T0.5490.97
59_L65_Y0.5480.97
35_P38_D0.5480.97
15_I18_T0.5410.97
82_G85_T0.5400.97
17_N83_D0.5340.96
29_Y32_A0.5210.96
33_V59_L0.5160.96
53_L56_N0.5160.96
26_V30_I0.5140.95
50_L53_L0.5140.95
41_A75_V0.5120.95
22_L43_V0.5090.95
45_N48_G0.5060.95
3_V9_E0.5040.95
8_K12_V0.5030.95
30_I45_N0.5010.95
22_L75_V0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dkhA 2 0.3516 10.5 0.882 Contact Map
3takA 2 0.6044 5.9 0.895 Contact Map
2ojpA 2 0.5934 5.3 0.898 Contact Map
2nuwA 3 0.5824 4.8 0.899 Contact Map
3eb2A 3 0.6154 4.8 0.9 Contact Map
4ur7A 3 0.6923 4.4 0.901 Contact Map
4hdeA 1 0.3407 4.4 0.902 Contact Map
1w3iA 3 0.5824 4.1 0.903 Contact Map
1s1dA 1 0.978 4 0.903 Contact Map
2pcqA 3 0.5495 3.8 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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