GREMLIN Database
DUF3842 - Domain of unknown function (DUF3842)
PFAM: PF12953 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 130 (129)
Sequences: 2528 (1681)
Seq/√Len: 148.0
META: 0.899

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_K96_P2.8931.00
19_K124_D2.8201.00
40_T53_T2.8151.00
98_K110_E2.7421.00
3_A65_A2.6891.00
78_N94_S2.6701.00
21_R49_N2.4921.00
40_T51_G2.3601.00
87_A90_E2.3041.00
59_V87_A2.2761.00
60_V78_N2.0711.00
68_I95_S2.0571.00
90_E94_S2.0311.00
50_R81_L1.9471.00
70_G74_I1.8311.00
100_I126_A1.7931.00
33_L58_I1.7931.00
69_I126_A1.7561.00
14_K18_E1.7511.00
75_V93_A1.7331.00
56_N78_N1.7241.00
69_I100_I1.6901.00
77_A86_P1.6881.00
3_A33_L1.6321.00
100_I112_V1.6181.00
118_P121_H1.6011.00
15_A123_I1.5781.00
16_I126_A1.5711.00
78_N90_E1.5701.00
72_I111_I1.5641.00
75_V101_L1.5541.00
5_I92_V1.5431.00
117_E125_E1.5371.00
112_V125_E1.4441.00
110_E129_K1.4321.00
115_S125_E1.3971.00
29_E50_R1.3751.00
55_E87_A1.3571.00
62_V68_I1.3551.00
1_R31_I1.3351.00
16_I69_I1.3311.00
37_A53_T1.3221.00
76_I109_V1.3211.00
44_L51_G1.2991.00
35_T84_I1.2781.00
4_V17_I1.2721.00
60_V64_K1.2641.00
58_I88_M1.2641.00
31_I50_R1.2371.00
19_K23_E1.2211.00
63_R96_P1.2181.00
117_E121_H1.2031.00
56_N60_V1.1831.00
74_I101_L1.1791.00
32_A43_M1.1781.00
1_R64_K1.1771.00
2_I28_V1.1651.00
76_I93_A1.1601.00
84_I88_M1.1601.00
98_K108_N1.1601.00
23_E128_E1.1511.00
75_V109_V1.1431.00
38_I41_S1.1200.99
21_R30_I1.1030.99
24_L28_V1.0600.99
99_K109_V1.0490.99
57_A85_T1.0480.99
24_L27_A1.0440.99
11_G80_M1.0400.99
63_R78_N1.0390.99
12_I104_L1.0150.99
32_A48_A0.9980.99
57_A61_N0.9870.99
17_I32_A0.9840.99
63_R94_S0.9840.99
11_G57_A0.9730.98
31_I61_N0.9700.98
99_K108_N0.9580.98
121_H124_D0.9270.98
1_R29_E0.9230.98
34_G40_T0.9190.98
73_G107_C0.9190.98
50_R106_Q0.9080.98
125_E129_K0.9060.98
3_A62_V0.8890.97
70_G101_L0.8870.97
60_V63_R0.8840.97
18_E22_E0.8730.97
3_A31_I0.8620.97
25_P28_V0.8260.96
69_I127_V0.8180.95
86_P94_S0.8160.95
89_A92_V0.8120.95
20_L100_I0.8090.95
4_V16_I0.8080.95
104_L117_E0.7950.95
102_L112_V0.7850.94
66_D96_P0.7770.94
30_I59_V0.7700.94
52_A56_N0.7650.94
1_R65_A0.7540.93
20_L30_I0.7520.93
23_E127_V0.7500.93
4_V30_I0.7400.92
38_I42_A0.7380.92
122_L125_E0.7330.92
29_E49_N0.7300.92
77_A111_I0.7260.92
5_I58_I0.7170.91
84_I92_V0.7150.91
37_A52_A0.7100.91
67_V98_K0.7070.91
117_E120_P0.6960.90
113_G122_L0.6910.90
42_A46_A0.6870.89
17_I25_P0.6860.89
33_L51_G0.6820.89
124_D128_E0.6780.89
12_I119_L0.6740.88
24_L127_V0.6730.88
112_V122_L0.6630.88
102_L122_L0.6630.88
67_V97_A0.6600.87
115_S122_L0.6560.87
72_I105_N0.6550.87
11_G18_E0.6540.87
88_M91_A0.6510.87
126_A129_K0.6500.87
59_V91_A0.6500.87
20_L69_I0.6470.86
61_N64_K0.6470.86
11_G14_K0.6440.86
35_T88_M0.6350.85
47_G73_G0.6340.85
12_I71_P0.6330.85
30_I49_N0.6230.84
26_E49_N0.6200.84
3_A51_G0.6190.84
33_L57_A0.6160.83
31_I64_K0.6070.83
40_T44_L0.6040.82
30_I47_G0.6040.82
71_P80_M0.5970.82
16_I20_L0.5940.81
62_V95_S0.5900.81
99_K106_Q0.5900.81
15_A18_E0.5890.81
77_A93_A0.5880.81
60_V85_T0.5880.81
27_A38_I0.5860.80
65_A97_A0.5810.80
62_V92_V0.5810.80
116_D128_E0.5790.80
81_L85_T0.5780.79
33_L65_A0.5710.79
104_L115_S0.5690.78
124_D127_V0.5690.78
7_G118_P0.5660.78
21_R28_V0.5650.78
77_A94_S0.5640.78
78_N86_P0.5620.78
8_Q85_T0.5610.77
17_I24_L0.5610.77
89_A93_A0.5590.77
36_N83_E0.5570.77
86_P89_A0.5570.77
76_I94_S0.5500.76
21_R24_L0.5430.75
30_I69_I0.5370.74
4_V13_G0.5360.74
62_V88_M0.5350.74
64_K108_N0.5330.74
19_K123_I0.5320.74
60_V90_E0.5300.73
81_L104_L0.5280.73
22_E26_E0.5260.73
95_S99_K0.5250.73
15_A19_K0.5240.73
121_H125_E0.5230.72
60_V94_S0.5190.72
10_G56_N0.5190.72
61_N81_L0.5180.72
14_K106_Q0.5180.72
68_I74_I0.5170.72
107_C111_I0.5160.71
14_K50_R0.5150.71
31_I65_A0.5140.71
10_G13_G0.5130.71
2_I27_A0.5100.71
84_I89_A0.5100.71
49_N121_H0.5040.70
98_K129_K0.5020.69
14_K42_A0.5010.69
18_E106_Q0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jl1A 2 0.9615 66.2 0.918 Contact Map
3istA 2 0.9846 64.3 0.919 Contact Map
2dwuA 2 0.9231 63.1 0.919 Contact Map
2jfqA 2 0.9769 61.5 0.92 Contact Map
1zuwA 2 0.9769 60.6 0.921 Contact Map
3e48A 2 0.9692 60.3 0.921 Contact Map
2vvtA 2 0.9769 60.3 0.921 Contact Map
2gzmA 3 0.9769 59.5 0.921 Contact Map
4ppmA 2 0 58 0.922 Contact Map
1yqdA 2 0.9462 57.4 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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