GREMLIN Database
DUF3841 - Domain of unknown function (DUF3841)
PFAM: PF12952 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 179 (175)
Sequences: 652 (563)
Seq/√Len: 42.6
META: 0.779

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_D61_Y4.1631.00
170_F173_L4.0171.00
48_Q152_E3.4071.00
121_E146_E3.3381.00
11_L15_E3.3181.00
48_Q52_R3.1531.00
10_V20_L2.8861.00
149_K152_E2.7781.00
86_V170_F2.7321.00
2_L168_A2.7001.00
111_D114_D2.6161.00
107_Y114_D2.4571.00
48_Q51_K2.2641.00
2_L65_A2.1751.00
73_L79_G2.0490.99
107_Y150_S2.0160.99
15_E175_K1.9970.99
24_R28_E1.9590.99
101_Y106_W1.9490.99
11_L178_V1.8950.99
49_M169_T1.8880.99
14_L178_V1.8860.99
8_E12_E1.8790.99
1_R85_E1.8410.98
109_P114_D1.8210.98
45_M94_S1.8170.98
175_K178_V1.7950.98
65_A168_A1.7740.98
20_L63_I1.7730.98
21_R58_G1.7660.98
86_V177_W1.7530.98
3_W83_E1.6910.97
145_R149_K1.6890.97
88_D168_A1.6880.97
90_E172_E1.6690.97
7_P10_V1.6300.97
174_R177_W1.6060.96
50_E55_K1.5980.96
117_A146_E1.5910.96
100_H103_L1.5510.95
21_R172_E1.5410.95
19_V58_G1.5400.95
19_V172_E1.5210.95
13_E17_T1.5200.95
45_M169_T1.4770.94
173_L178_V1.4650.94
157_L166_I1.4590.94
94_S100_H1.4240.93
102_V154_I1.4120.93
65_A170_F1.3600.91
66_W96_F1.3560.91
22_A27_I1.3520.91
68_R72_H1.3340.90
113_E117_A1.3050.89
2_L91_V1.2720.88
10_V63_I1.2310.86
1_R89_E1.2080.85
65_A86_V1.2010.85
45_M92_L1.1840.84
121_E143_L1.1830.84
23_K26_Y1.1810.84
143_L147_I1.1790.84
138_N142_E1.1610.83
100_H104_N1.1600.83
52_R152_E1.1330.81
49_M53_V1.1270.81
14_L173_L1.1230.81
25_E146_E1.1210.80
128_D131_D1.1190.80
67_Y93_L1.1100.80
108_L159_I1.0780.78
9_E12_E1.0780.78
45_M49_M1.0760.78
143_L146_E1.0700.77
154_I157_L1.0660.77
56_P59_V1.0520.76
95_D171_W1.0490.76
148_E152_E1.0450.75
50_E56_P1.0140.73
71_G76_G1.0110.73
65_A173_L1.0100.73
151_W155_F1.0040.73
135_S147_I0.9980.72
115_E119_E0.9970.72
121_E125_Y0.9930.72
93_L166_I0.9870.71
90_E177_W0.9840.71
116_E120_K0.9670.70
66_W94_S0.9600.69
56_P171_W0.9490.68
49_M52_R0.9390.67
4_T22_A0.9130.65
145_R148_E0.9120.65
49_M92_L0.9110.65
14_L20_L0.9040.64
151_W154_I0.8970.64
98_K109_P0.8940.63
141_P145_R0.8860.63
91_V168_A0.8750.62
54_P117_A0.8700.61
22_A63_I0.8670.61
24_R43_D0.8630.61
160_W163_D0.8600.60
16_K46_V0.8580.60
87_P177_W0.8580.60
96_F100_H0.8570.60
103_L167_Q0.8570.60
76_G79_G0.8570.60
24_R39_L0.8520.60
110_K153_R0.8500.60
94_S167_Q0.8460.59
68_R71_G0.8450.59
38_F103_L0.8440.59
142_E145_R0.8440.59
53_V101_Y0.8170.57
127_I142_E0.8160.56
99_W151_W0.8100.56
81_R159_I0.8070.56
117_A120_K0.8070.56
87_P90_E0.7970.55
47_E145_R0.7960.55
41_A100_H0.7950.54
114_D117_A0.7940.54
51_K174_R0.7910.54
22_A30_K0.7890.54
11_L14_L0.7890.54
44_W48_Q0.7790.53
119_E123_E0.7750.53
41_A102_V0.7700.52
97_D115_E0.7660.52
49_M94_S0.7640.52
101_Y105_Y0.7580.51
140_Y144_K0.7530.50
10_V22_A0.7520.50
119_E124_K0.7500.50
114_D153_R0.7500.50
27_I31_Y0.7430.50
101_Y109_P0.7390.49
98_K118_F0.7390.49
7_P85_E0.7370.49
45_M103_L0.7350.49
11_L65_A0.7290.48
112_E115_E0.7250.48
144_K148_E0.7230.48
57_E85_E0.7220.48
21_R59_V0.7200.47
58_G168_A0.7130.47
112_E116_E0.7110.47
108_L123_E0.7090.46
1_R83_E0.7010.46
9_E13_E0.6930.45
75_P79_G0.6910.45
31_Y38_F0.6900.45
51_K152_E0.6880.44
28_E87_P0.6840.44
92_L156_D0.6780.43
52_R116_E0.6770.43
128_D134_L0.6760.43
6_Q10_V0.6710.43
121_E142_E0.6690.43
11_L80_V0.6640.42
28_E31_Y0.6630.42
33_E36_D0.6570.41
66_W128_D0.6560.41
11_L175_K0.6480.41
113_E124_K0.6450.40
51_K116_E0.6450.40
53_V106_W0.6440.40
37_I102_V0.6430.40
20_L152_E0.6420.40
26_Y30_K0.6410.40
112_E117_A0.6360.40
71_G75_P0.6340.39
63_I85_E0.6340.39
166_I170_F0.6340.39
102_V158_D0.6330.39
55_K59_V0.6320.39
60_E126_G0.6320.39
1_R15_E0.6310.39
19_V174_R0.6300.39
47_E148_E0.6300.39
101_Y108_L0.6300.39
94_S169_T0.6300.39
104_N108_L0.6290.39
89_E117_A0.6250.39
68_R81_R0.6240.39
109_P115_E0.6220.38
30_K87_P0.6200.38
138_N145_R0.6190.38
96_F167_Q0.6180.38
122_L127_I0.6160.38
68_R73_L0.6160.38
27_I30_K0.6160.38
111_D149_K0.6140.38
52_R158_D0.6130.38
104_N109_P0.6110.37
85_E88_D0.6050.37
59_V178_V0.6020.37
45_M72_H0.6020.37
3_W62_P0.6020.37
34_I37_I0.6010.36
2_L5_I0.6000.36
65_A169_T0.5950.36
27_I39_L0.5890.35
22_A26_Y0.5850.35
9_E21_R0.5830.35
45_M100_H0.5820.35
67_Y102_V0.5810.35
58_G162_K0.5800.35
160_W164_K0.5790.35
71_G81_R0.5770.34
101_Y169_T0.5770.34
45_M69_R0.5750.34
111_D147_I0.5740.34
38_F100_H0.5740.34
88_D177_W0.5740.34
98_K101_Y0.5740.34
54_P135_S0.5720.34
90_E145_R0.5670.34
139_F144_K0.5660.33
96_F154_I0.5650.33
71_G96_F0.5640.33
30_K139_F0.5630.33
5_I68_R0.5580.33
113_E149_K0.5570.33
78_G115_E0.5520.32
17_T57_E0.5510.32
107_Y147_I0.5510.32
3_W95_D0.5500.32
70_E75_P0.5500.32
18_G64_W0.5490.32
114_D122_L0.5470.32
71_G79_G0.5450.32
89_E158_D0.5450.32
18_G175_K0.5440.32
2_L178_V0.5420.31
58_G172_E0.5390.31
17_T25_E0.5390.31
66_W100_H0.5370.31
34_I44_W0.5330.31
53_V173_L0.5280.30
2_L84_L0.5270.30
16_K75_P0.5270.30
94_S154_I0.5260.30
73_L76_G0.5260.30
160_W169_T0.5250.30
10_V82_L0.5210.30
77_E152_E0.5210.30
34_I71_G0.5210.30
146_E177_W0.5190.30
67_Y165_S0.5150.29
48_Q154_I0.5130.29
10_V177_W0.5130.29
129_E167_Q0.5120.29
51_K128_D0.5120.29
68_R75_P0.5120.29
8_E80_V0.5110.29
59_V118_F0.5080.29
28_E39_L0.5060.29
60_E140_Y0.5050.29
4_T15_E0.5040.28
11_L84_L0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lr0A 2 0.4302 5.1 0.957 Contact Map
4g2kA 3 0.2849 4.7 0.958 Contact Map
3te8A 2 0.4804 4.5 0.959 Contact Map
1h12A 1 0.3575 3.3 0.961 Contact Map
4oayA 2 0.1564 3 0.962 Contact Map
4jprA 3 0.2849 2.8 0.963 Contact Map
1guuA 1 0.2793 2.5 0.964 Contact Map
4n21A 3 0.3073 2.5 0.964 Contact Map
2gzsA 1 0.2626 2.4 0.964 Contact Map
1w36C 1 0.8827 2.3 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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