GREMLIN Database
Kri1_C - KRI1-like family C-terminal
PFAM: PF12936 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 89 (86)
Sequences: 639 (453)
Seq/√Len: 48.8
META: 0.336

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_D50_E3.1011.00
20_G24_T2.5301.00
18_I23_P2.4101.00
52_N56_S2.2141.00
8_D11_Y2.1091.00
17_D21_D2.0601.00
59_K64_R1.9540.99
16_E19_I1.9260.99
82_L86_R1.9070.99
30_E33_P1.8740.99
2_K5_E1.7500.99
11_Y16_E1.7270.98
31_V63_Y1.6740.98
40_A45_L1.6700.98
78_K85_W1.6460.98
40_A43_I1.6040.98
76_L80_A1.5740.97
15_Y25_R1.5410.97
22_L25_R1.4550.96
77_G81_R1.4430.95
13_L25_R1.4260.95
75_K78_K1.4040.95
34_N66_E1.3940.94
55_V60_L1.3400.93
71_K75_K1.2980.92
76_L79_K1.2680.91
37_G58_K1.2460.90
41_E48_D1.2370.90
17_D22_L1.2310.90
80_A84_E1.2300.90
10_Y15_Y1.1970.88
11_Y14_D1.1910.88
20_G23_P1.1780.88
10_Y16_E1.1700.87
32_S55_V1.1530.86
71_K74_K1.1310.85
24_T27_K1.1200.85
5_E57_L1.0680.82
75_K85_W1.0600.81
13_L17_D1.0450.81
78_K82_L1.0390.80
58_K64_R1.0230.79
9_E13_L1.0100.78
81_R85_W1.0070.78
66_E70_R1.0010.78
34_N55_V0.9970.77
57_L60_L0.9910.77
46_A54_F0.9710.75
41_E45_L0.9650.75
17_D25_R0.9600.75
15_Y24_T0.9560.74
21_D24_T0.9480.74
31_V45_L0.9420.73
82_L85_W0.9400.73
14_D17_D0.9380.73
16_E21_D0.9360.73
9_E12_K0.9330.72
6_L15_Y0.9250.72
36_F64_R0.9200.71
35_S54_F0.8990.70
29_R54_F0.8910.69
38_L42_E0.8910.69
17_D55_V0.8880.69
31_V69_K0.8790.68
72_D78_K0.8710.67
38_L54_F0.8670.67
32_S67_E0.8640.66
72_D76_L0.8640.66
4_E65_D0.8570.66
62_P70_R0.8390.64
74_K79_K0.8250.63
19_I24_T0.8230.63
38_L46_A0.8170.62
14_D19_I0.8040.61
20_G27_K0.8040.61
65_D68_K0.8000.60
15_Y20_G0.7940.60
2_K22_L0.7880.59
46_A77_G0.7870.59
84_E87_K0.7780.58
54_F61_A0.7420.55
54_F69_K0.7300.54
46_A72_D0.7180.52
43_I68_K0.7140.52
18_I44_L0.7100.52
35_S53_Q0.7050.51
45_L61_A0.6990.50
19_I25_R0.6980.50
43_I48_D0.6980.50
16_E23_P0.6980.50
13_L16_E0.6950.50
9_E49_K0.6840.49
62_P82_L0.6830.49
19_I22_L0.6820.49
3_L6_L0.6800.48
60_L74_K0.6780.48
72_D80_A0.6760.48
6_L76_L0.6730.48
47_D62_P0.6710.48
10_Y14_D0.6510.46
74_K78_K0.6480.45
22_L50_E0.6470.45
27_K30_E0.6410.45
17_D24_T0.6290.43
42_E46_A0.6280.43
48_D61_A0.6230.43
10_Y13_L0.6160.42
33_P59_K0.5930.40
15_Y19_I0.5930.40
17_D23_P0.5910.40
28_Y33_P0.5860.39
72_D82_L0.5830.39
71_K78_K0.5660.37
68_K72_D0.5640.37
77_G80_A0.5630.37
21_D27_K0.5630.37
15_Y23_P0.5620.37
49_K53_Q0.5500.36
35_S67_E0.5500.36
68_K78_K0.5500.36
28_Y31_V0.5450.35
49_K66_E0.5420.35
70_R74_K0.5340.34
4_E72_D0.5320.34
26_F29_R0.5100.32
81_R84_E0.5080.32
14_D20_G0.5070.32
15_Y21_D0.5010.31
8_D67_E0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1awcA 1 0.6067 11.5 0.918 Contact Map
3wtsC 1 0.5506 8.7 0.923 Contact Map
1gvjA 2 0.6067 7.8 0.924 Contact Map
3szrA 2 0.9101 6.6 0.927 Contact Map
1jrmA 1 0.573 5.6 0.929 Contact Map
3dptA 2 0.7079 3.5 0.936 Contact Map
4dhiB 1 0.9775 3.5 0.936 Contact Map
2q5zA 4 0.6404 3.4 0.936 Contact Map
1vx7g 1 0.3596 3.3 0.936 Contact Map
3a5tA 2 0.6067 3.2 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0056 seconds.