GREMLIN Database
Cnd1_N - non-SMC mitotic condensation complex subunit 1, N-term
PFAM: PF12922 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 169 (164)
Sequences: 546 (393)
Seq/√Len: 30.6
META: 0.194

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_E122_R3.8931.00
134_Y165_H3.1781.00
81_K84_K3.0721.00
47_F51_W2.9381.00
165_H168_G2.6991.00
40_N44_M2.5921.00
159_A165_H2.5290.99
130_T159_A2.4760.99
44_M48_L2.3310.99
159_A163_H2.3060.99
112_L116_W2.1590.98
101_L108_L2.1110.98
6_K9_D1.9310.97
19_A107_V1.9270.97
13_S91_W1.9160.96
118_T121_E1.8750.96
146_T156_L1.8370.95
112_L128_L1.8300.95
125_F161_K1.7820.95
39_K121_E1.7600.94
137_L143_V1.7340.94
130_T165_H1.7230.94
112_L153_F1.6650.92
28_S114_R1.6560.92
40_N43_E1.6490.92
121_E132_P1.6010.91
16_S24_A1.5870.90
120_S129_F1.5720.90
101_L132_P1.5550.89
28_S37_A1.5510.89
72_R78_K1.5280.89
42_L112_L1.5050.88
38_H130_T1.4810.87
70_A73_G1.4390.85
135_L156_L1.4310.85
127_S132_P1.4220.85
51_W101_L1.3920.83
74_R97_R1.3870.83
11_L145_N1.3860.83
120_S124_T1.3830.83
127_S167_L1.3600.82
11_L99_R1.3580.82
71_A75_G1.3500.81
121_E163_H1.3450.81
39_K118_T1.3400.81
130_T134_Y1.3320.81
123_D150_M1.3240.80
131_R159_A1.3210.80
160_V165_H1.3150.80
78_K81_K1.2690.77
11_L14_G1.2630.77
43_E121_E1.2590.77
116_W142_R1.2570.76
71_A74_R1.2570.76
9_D47_F1.2530.76
64_S168_G1.2520.76
137_L152_I1.2330.75
126_I159_A1.2200.74
4_L59_K1.2100.74
107_V125_F1.2080.74
46_A125_F1.2020.73
82_K87_K1.1990.73
41_A141_Q1.1910.72
97_R137_L1.1790.72
43_E157_C1.1760.71
83_K87_K1.1710.71
24_A33_D1.1700.71
14_G114_R1.1460.69
93_W108_L1.1400.69
19_A103_L1.1400.69
7_L133_C1.1360.69
7_L15_L1.1070.67
47_F128_L1.1020.66
82_K95_E1.0880.65
25_D38_H1.0880.65
157_C162_H1.0820.65
121_E136_I1.0790.65
107_V110_L1.0770.65
35_R39_K1.0700.64
45_Y144_K1.0650.64
150_M154_K1.0590.63
23_H116_W1.0520.63
132_P148_I1.0470.62
27_E32_Q1.0350.61
122_R126_I1.0340.61
97_R163_H1.0340.61
46_A58_T1.0270.61
132_P140_E1.0270.61
104_L137_L1.0270.61
43_E115_L1.0260.61
7_L136_I1.0090.59
33_D72_R1.0070.59
11_L21_A1.0040.59
18_L90_G0.9930.58
18_L38_H0.9930.58
35_R93_W0.9780.57
18_L25_D0.9600.56
26_L95_E0.9580.55
126_I165_H0.9430.54
75_G94_E0.9410.54
47_F120_S0.9340.54
118_T122_R0.9260.53
140_E163_H0.9180.52
15_L21_A0.9170.52
43_E123_D0.9070.51
18_L150_M0.9070.51
14_G48_L0.9050.51
107_V119_T0.8980.51
72_R126_I0.8930.50
80_K86_K0.8880.50
35_R111_K0.8860.50
123_D140_E0.8840.50
9_D51_W0.8740.49
116_W151_A0.8740.49
118_T159_A0.8740.49
65_S85_K0.8730.49
158_I167_L0.8640.48
49_L149_R0.8580.47
40_N94_E0.8570.47
68_A72_R0.8550.47
37_A41_A0.8500.47
29_D32_Q0.8440.46
57_E139_N0.8390.46
161_K164_G0.8320.45
66_A141_Q0.8290.45
118_T163_H0.8250.45
47_F56_V0.8240.45
164_G167_L0.8220.45
156_L162_H0.8130.44
18_L63_K0.8120.44
39_K131_R0.8090.44
131_R160_V0.8030.43
161_K165_H0.8010.43
17_A121_E0.7970.43
58_T164_G0.7960.43
69_P72_R0.7920.42
47_F157_C0.7910.42
13_S144_K0.7840.42
43_E132_P0.7720.41
21_A24_A0.7690.40
79_G83_K0.7650.40
39_K133_C0.7620.40
79_G84_K0.7570.39
74_R148_I0.7560.39
26_L37_A0.7530.39
137_L151_A0.7480.39
43_E133_C0.7480.39
14_G17_A0.7480.39
45_Y56_V0.7460.39
79_G82_K0.7460.39
52_L116_W0.7450.39
74_R81_K0.7450.39
61_A139_N0.7410.38
42_L87_K0.7340.38
103_L114_R0.7300.37
159_A164_G0.7290.37
59_K137_L0.7270.37
39_K164_G0.7250.37
112_L119_T0.7250.37
136_I152_I0.7200.37
7_L52_L0.7160.36
160_V166_A0.7130.36
43_E46_A0.7120.36
22_L148_I0.7080.36
27_E158_I0.7070.36
149_R159_A0.7020.35
105_C139_N0.6990.35
26_L34_D0.6930.35
15_L45_Y0.6860.34
36_A168_G0.6780.34
8_L127_S0.6780.34
120_S144_K0.6660.33
128_L162_H0.6600.32
102_D151_A0.6550.32
139_N166_A0.6470.31
16_S60_A0.6470.31
67_A79_G0.6430.31
146_T162_H0.6420.31
91_W96_Q0.6420.31
13_S96_Q0.6380.31
91_W116_W0.6370.31
42_L136_I0.6330.30
44_M50_Q0.6310.30
94_E97_R0.6300.30
28_S95_E0.6290.30
11_L17_A0.6290.30
58_T152_I0.6270.30
98_Q151_A0.6250.30
6_K51_W0.6180.29
8_L51_W0.6170.29
137_L153_F0.6160.29
28_S74_R0.6160.29
15_L22_L0.6150.29
10_L112_L0.6140.29
101_L113_S0.6100.29
55_A69_P0.6060.29
65_S73_G0.6060.29
123_D144_K0.6050.29
17_A21_A0.6010.28
132_P136_I0.5980.28
40_N126_I0.5970.28
121_E133_C0.5930.28
113_S127_S0.5900.28
45_Y120_S0.5870.27
123_D130_T0.5860.27
44_M167_L0.5800.27
118_T131_R0.5780.27
45_Y145_N0.5760.27
52_L108_L0.5760.27
7_L12_V0.5730.27
22_L126_I0.5720.26
61_A143_V0.5720.26
15_L23_H0.5640.26
41_A151_A0.5570.26
79_G139_N0.5520.25
18_L155_V0.5500.25
4_L148_I0.5470.25
108_L136_I0.5470.25
154_K164_G0.5460.25
7_L47_F0.5460.25
17_A168_G0.5410.25
131_R135_L0.5410.25
66_A92_D0.5400.25
61_A87_K0.5370.24
18_L22_L0.5360.24
107_V129_F0.5340.24
40_N115_L0.5340.24
5_S74_R0.5340.24
22_L25_D0.5320.24
100_A103_L0.5310.24
22_L62_E0.5310.24
46_A106_K0.5270.24
41_A160_V0.5270.24
49_L90_G0.5260.24
33_D74_R0.5210.23
35_R115_L0.5200.23
150_M163_H0.5160.23
46_A122_R0.5130.23
97_R127_S0.5120.23
34_D160_V0.5100.23
50_Q131_R0.5090.23
8_L29_D0.5080.23
119_T149_R0.5070.23
21_A26_L0.5040.22
125_F138_E0.5020.22
19_A71_A0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m62A 1 0.9053 11.7 0.935 Contact Map
3zkvA 1 0.9172 6 0.943 Contact Map
3wozA 1 0.8876 5.6 0.944 Contact Map
2gutA 1 0.3905 5.4 0.944 Contact Map
3nxbA 1 0.4497 5.3 0.945 Contact Map
2bptA 1 0.7751 4.2 0.947 Contact Map
4pjwA 1 0.8462 3.9 0.948 Contact Map
3uv5A 1 0.4852 3.9 0.948 Contact Map
1qgrA 1 0.9053 3.9 0.948 Contact Map
3ibvA 1 0.8402 3.6 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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