GREMLIN Database
DUF3821 - Domain of unknown function (DUF3821)
PFAM: PF12863 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 209 (207)
Sequences: 882 (704)
Seq/√Len: 48.9
META: 0.964

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_G49_S4.1691.00
132_I200_A3.9421.00
136_V147_L3.8101.00
178_W184_D3.3011.00
202_S207_M3.2211.00
119_A204_L3.1641.00
42_I56_D3.1021.00
201_E208_K3.0411.00
53_S56_D2.8541.00
135_K201_E2.6811.00
40_K60_Y2.4611.00
63_N75_V2.4101.00
87_K113_D2.3771.00
25_G67_L2.3501.00
91_A109_N2.3361.00
138_T144_Y2.3011.00
24_I27_W2.2311.00
31_A36_T2.1591.00
50_F57_F2.1541.00
30_G33_I2.1281.00
58_G61_T2.1181.00
66_L76_A2.0041.00
46_D49_S1.9720.99
5_V52_V1.9170.99
57_F79_V1.9020.99
69_G72_G1.8890.99
32_D36_T1.8740.99
137_K143_T1.8720.99
14_I17_A1.7920.99
6_F118_S1.7450.99
149_G155_T1.6950.98
51_Y54_P1.6880.98
18_L21_G1.6190.98
26_W64_W1.5660.97
15_T19_G1.5570.97
54_P111_R1.5520.97
171_P175_G1.5280.97
135_K199_W1.5230.97
199_W202_S1.5220.97
30_G36_T1.5210.97
44_V47_P1.5200.97
33_I36_T1.5120.96
89_W111_R1.5090.96
138_T193_A1.5020.96
18_L66_L1.4980.96
13_D16_A1.4920.96
32_D35_T1.4520.96
125_V128_A1.4480.96
19_G66_L1.4430.95
160_L167_W1.3930.94
88_V198_V1.3830.94
10_E206_N1.3720.94
147_L169_W1.3390.93
17_A77_F1.3340.93
178_W186_N1.3230.93
25_G37_A1.3160.93
136_V157_L1.3120.92
116_L202_S1.2940.92
39_T64_W1.2790.91
61_T81_D1.2620.91
137_K199_W1.2600.91
97_V108_L1.2550.91
180_T184_D1.2530.91
14_I77_F1.2420.90
31_A39_T1.2410.90
157_L160_L1.2380.90
21_G66_L1.2290.90
5_V57_F1.2260.90
27_W76_A1.2210.89
5_V8_G1.2170.89
25_G36_T1.2040.89
44_V50_F1.1890.88
191_Y194_G1.1780.88
189_R193_A1.1730.87
21_G47_P1.1660.87
52_V79_V1.1640.87
16_A19_G1.1540.87
152_G155_T1.1400.86
40_K56_D1.1370.86
4_T80_Q1.1360.86
135_K145_T1.1270.85
85_D117_Y1.1260.85
149_G152_G1.1220.85
178_W183_L1.1200.85
143_T146_S1.0990.84
160_L169_W1.0890.83
190_L193_A1.0840.83
199_W203_N1.0760.82
151_N155_T1.0700.82
6_F14_I1.0680.82
9_E12_L1.0630.82
104_R189_R1.0470.81
175_G179_N1.0440.80
147_L180_T1.0300.80
24_I77_F1.0180.79
198_V202_S1.0140.79
179_N182_A1.0090.78
27_W30_G1.0060.78
25_G30_G1.0020.78
80_Q118_S0.9890.77
6_F9_E0.9730.76
30_G39_T0.9660.75
132_I142_A0.9610.75
138_T142_A0.9600.75
2_G9_E0.9590.75
20_G47_P0.9580.74
38_P57_F0.9530.74
133_D199_W0.9470.74
5_V9_E0.9460.73
119_A202_S0.9410.73
66_L74_G0.9380.73
14_I24_I0.9340.73
125_V129_D0.9270.72
203_N208_K0.9270.72
2_G6_F0.9250.72
38_P41_T0.9200.71
184_D188_Q0.9170.71
96_D100_K0.9170.71
139_P190_L0.9090.70
85_D113_D0.8990.70
43_T46_D0.8970.69
41_T67_L0.8970.69
23_T41_T0.8930.69
7_I57_F0.8910.69
26_W39_T0.8900.69
152_G156_S0.8880.69
89_W109_N0.8830.68
46_D50_F0.8810.68
54_P58_G0.8800.68
2_G8_G0.8760.68
5_V77_F0.8760.68
58_G81_D0.8700.67
80_Q193_A0.8650.67
18_L60_Y0.8630.66
148_Y152_G0.8590.66
123_P127_P0.8580.66
102_V108_L0.8510.65
14_I18_L0.8490.65
12_L52_V0.8410.64
5_V24_I0.8380.64
54_P113_D0.8360.64
53_S132_I0.8310.63
97_V102_V0.8300.63
90_D103_P0.8260.63
17_A66_L0.8250.63
25_G28_A0.8200.62
178_W182_A0.8200.62
135_K158_T0.8200.62
102_V138_T0.8140.62
87_K111_R0.8140.62
27_W33_I0.8030.61
17_A21_G0.8020.61
126_N129_D0.8000.61
68_N72_G0.7940.60
24_I29_S0.7850.59
73_G76_A0.7760.58
40_K80_Q0.7740.58
29_S36_T0.7650.57
17_A68_N0.7630.57
166_P169_W0.7610.57
86_L112_I0.7600.57
36_T39_T0.7580.56
94_N98_T0.7570.56
177_G180_T0.7490.55
18_L47_P0.7480.55
133_D159_N0.7480.55
3_A16_A0.7480.55
24_I28_A0.7430.55
63_N78_N0.7410.55
187_G197_T0.7360.54
120_T123_P0.7350.54
40_K44_V0.7350.54
125_V161_N0.7340.54
193_A196_Y0.7340.54
121_Q127_P0.7340.54
57_F77_F0.7290.53
35_T38_P0.7260.53
107_N150_N0.7250.53
68_N74_G0.7240.53
189_R192_P0.7240.53
88_V168_Y0.7210.53
2_G141_G0.7200.53
12_L105_G0.7200.53
29_S64_W0.7200.53
127_P131_Y0.7200.53
36_T40_K0.7170.52
110_F157_L0.7130.52
36_T77_F0.7100.52
69_G74_G0.7040.51
45_S52_V0.7020.51
170_T173_A0.6980.50
15_T44_V0.6940.50
86_L110_F0.6920.50
15_T112_I0.6920.50
26_W29_S0.6910.50
43_T106_T0.6880.49
176_G182_A0.6870.49
133_D203_N0.6870.49
57_F64_W0.6860.49
134_I141_G0.6860.49
26_W31_A0.6810.49
123_P165_S0.6790.48
100_K103_P0.6790.48
139_P142_A0.6790.48
25_G38_P0.6750.48
87_K98_T0.6750.48
17_A24_I0.6730.48
77_F164_T0.6720.48
142_A200_A0.6700.48
11_G137_K0.6690.47
137_K198_V0.6690.47
114_T117_Y0.6690.47
13_D37_A0.6680.47
84_L200_A0.6680.47
92_T126_N0.6650.47
178_W181_G0.6650.47
184_D189_R0.6610.47
126_N174_T0.6520.46
27_W31_A0.6510.46
6_F59_G0.6500.45
25_G31_A0.6480.45
13_D17_A0.6430.45
116_L143_T0.6420.45
67_L75_V0.6410.45
105_G112_I0.6410.45
53_S57_F0.6400.44
86_L148_Y0.6390.44
2_G5_V0.6380.44
71_G74_G0.6310.44
92_T95_K0.6290.43
21_G74_G0.6280.43
3_A119_A0.6280.43
155_T170_T0.6260.43
177_G181_G0.6250.43
179_N184_D0.6230.43
41_T45_S0.6220.43
165_S168_Y0.6190.42
157_L163_T0.6190.42
112_I168_Y0.6190.42
48_T72_G0.6180.42
164_T168_Y0.6140.42
174_T183_L0.6120.42
120_T125_V0.6090.41
132_I166_P0.6060.41
62_G79_V0.6050.41
112_I193_A0.6040.41
140_D192_P0.6030.41
170_T174_T0.6030.41
64_W98_T0.6020.41
28_A31_A0.6000.41
146_S152_G0.6000.41
172_G175_G0.5970.40
165_S169_W0.5920.40
82_P102_V0.5900.40
74_G112_I0.5850.39
180_T183_L0.5850.39
20_G83_S0.5850.39
191_Y205_N0.5840.39
89_W93_T0.5840.39
14_I27_W0.5760.38
84_L116_L0.5760.38
33_I42_I0.5750.38
164_T176_G0.5750.38
108_L138_T0.5740.38
54_P62_G0.5730.38
185_P188_Q0.5710.38
183_L190_L0.5660.37
77_F169_W0.5580.36
124_G161_N0.5540.36
5_V102_V0.5530.36
67_L71_G0.5530.36
27_W38_P0.5520.36
123_P128_A0.5500.36
61_T80_Q0.5500.36
91_A108_L0.5500.36
192_P195_T0.5490.36
132_I145_T0.5470.35
17_A76_A0.5450.35
94_N143_T0.5440.35
33_I86_L0.5440.35
105_G144_Y0.5420.35
105_G109_N0.5400.35
179_N183_L0.5380.35
97_V100_K0.5360.34
37_A71_G0.5340.34
28_A100_K0.5320.34
47_P50_F0.5310.34
36_T53_S0.5310.34
52_V105_G0.5290.34
39_T44_V0.5270.34
105_G169_W0.5230.33
103_P142_A0.5220.33
193_A197_T0.5200.33
112_I161_N0.5150.33
24_I114_T0.5140.32
33_I67_L0.5130.32
54_P59_G0.5110.32
25_G41_T0.5100.32
77_F122_R0.5100.32
199_W207_M0.5090.32
135_K143_T0.5080.32
28_A97_V0.5080.32
95_K98_T0.5080.32
116_L132_I0.5080.32
44_V66_L0.5070.32
8_G115_N0.5060.32
74_G83_S0.5040.32
28_A39_T0.5040.32
14_I21_G0.5000.31
22_T68_N0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3isyA 1 0.4976 43.9 0.939 Contact Map
3osvA 2 0.4402 27.3 0.945 Contact Map
4ziqA 2 0.7129 24.1 0.947 Contact Map
3c12A 2 0.4641 20.7 0.948 Contact Map
2p9rA 1 0.4258 15.2 0.951 Contact Map
2ee9A 1 0.3732 11.7 0.954 Contact Map
3iduA 1 0.4833 11.6 0.954 Contact Map
3prxB 1 0.7464 9.6 0.956 Contact Map
4fxkA 1 0.7847 9.5 0.956 Contact Map
2d7nA 1 0.3493 9.4 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0077 seconds.