GREMLIN Database
QSregVF_b - Putative quorum-sensing-regulated virulence factor
PFAM: PF12843 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 66 (65)
Sequences: 5026 (2357)
Seq/√Len: 292.3
META: 0.88

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_E43_K3.7071.00
28_E32_V2.5401.00
52_Y56_L2.1471.00
12_K22_L2.0341.00
11_T47_L1.9931.00
35_A49_A1.9911.00
55_K60_E1.8501.00
26_L31_L1.8451.00
15_F34_F1.8371.00
61_Y64_K1.7531.00
46_E49_A1.6171.00
49_A53_E1.5711.00
26_L34_F1.5601.00
23_L51_M1.5401.00
32_V52_Y1.4911.00
46_E50_L1.4731.00
4_D46_E1.4351.00
6_L10_T1.4151.00
8_L51_M1.3531.00
53_E57_N1.3351.00
3_E7_E1.3311.00
7_E11_T1.3211.00
12_K20_G1.2731.00
4_D50_L1.2721.00
18_Y21_R1.2721.00
28_E56_L1.2251.00
24_I63_L1.1981.00
53_E56_L1.1771.00
31_L51_M1.1591.00
43_K47_L1.0951.00
43_K46_E1.0921.00
12_K19_K1.0601.00
34_F37_K1.0271.00
32_V36_R0.9861.00
21_R25_D0.9661.00
31_L48_L0.9541.00
29_P32_V0.9151.00
35_A39_F0.9071.00
11_T22_L0.8951.00
4_D47_L0.8941.00
31_L52_Y0.8911.00
8_L11_T0.8861.00
62_L65_P0.8741.00
2_P6_L0.8611.00
23_L44_L0.8551.00
61_Y65_P0.8451.00
3_E6_L0.8431.00
4_D7_E0.8211.00
29_P37_K0.7990.99
34_F48_L0.7980.99
8_L47_L0.7940.99
35_A52_Y0.7760.99
9_A24_I0.7590.99
51_M63_L0.7450.99
40_P45_G0.7440.99
32_V60_E0.7340.99
10_T22_L0.7310.99
54_I57_N0.7270.99
60_E64_K0.7190.99
41_K46_E0.7150.99
6_L9_A0.7090.99
14_P44_L0.6990.99
8_L50_L0.6950.99
23_L47_L0.6920.99
22_L25_D0.6920.99
59_L62_L0.6900.98
18_Y29_P0.6870.98
25_D64_K0.6870.98
50_L53_E0.6800.98
28_E55_K0.6790.98
34_F38_G0.6780.98
10_T66_L0.6780.98
51_M55_K0.6710.98
41_K49_A0.6700.98
32_V56_L0.6660.98
34_F40_P0.6660.98
9_A66_L0.6580.98
27_P30_Y0.6430.98
38_G45_G0.6400.98
28_E60_E0.6290.97
4_D8_L0.6240.97
51_M54_I0.6190.97
47_L51_M0.6090.97
26_L29_P0.5960.96
5_L8_L0.5870.96
39_F52_Y0.5840.96
17_K29_P0.5740.95
51_M60_E0.5700.95
22_L51_M0.5700.95
7_E47_L0.5470.94
15_F42_G0.5440.94
29_P34_F0.5390.94
38_G48_L0.5310.93
32_V35_A0.5220.92
35_A56_L0.5220.92
50_L54_I0.5180.92
4_D10_T0.5150.92
38_G49_A0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kmgA 2 0.6212 13.5 0.896 Contact Map
3izxA 3 0.803 7.8 0.907 Contact Map
4lkpA 1 0.803 6 0.912 Contact Map
4eieA 1 0.5758 5.9 0.912 Contact Map
1azoA 1 0.8939 5.8 0.912 Contact Map
4ynsA 2 0.8636 5.7 0.912 Contact Map
1z21A 1 0.5758 5.4 0.913 Contact Map
1cxcA 1 0.5606 5.3 0.913 Contact Map
4i3bA 2 0.7879 4.9 0.915 Contact Map
2p9xA 4 0.7424 4.6 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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