GREMLIN Database
DUF3817 - Domain of unknown function (DUF3817)
PFAM: PF12823 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (81)
Sequences: 10496 (6380)
Seq/√Len: 708.9
META: 0.829

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_A61_T3.6631.00
34_M38_V2.6421.00
64_A77_V2.4291.00
30_K34_M2.4171.00
49_L53_R2.1041.00
23_P27_L2.1031.00
19_F23_P2.0891.00
3_R49_L1.9871.00
22_M26_Y1.9691.00
48_L52_R1.9171.00
47_A64_A1.9041.00
2_K6_V1.6891.00
56_W60_R1.5041.00
21_A28_A1.4641.00
20_V24_L1.4521.00
57_S60_R1.4471.00
17_L32_V1.4401.00
14_S39_L1.4311.00
28_A31_I1.3921.00
20_V23_P1.3711.00
41_I45_V1.3241.00
7_I42_A1.2971.00
45_V49_L1.2891.00
7_I46_L1.2661.00
31_I34_M1.2551.00
73_G76_V1.2391.00
16_L72_F1.2331.00
50_L54_L1.2321.00
21_A29_V1.2111.00
3_R46_L1.1691.00
28_A32_V1.1251.00
3_R6_V1.1141.00
9_I13_V1.0951.00
58_L62_L1.0951.00
2_K5_R1.0781.00
52_R55_R1.0661.00
47_A61_T1.0411.00
6_V10_L1.0401.00
47_A65_L1.0391.00
8_A74_T1.0181.00
38_V41_I1.0181.00
29_V33_G1.0111.00
59_K63_L1.0021.00
13_V17_L0.9991.00
19_F22_M0.9851.00
4_F50_L0.9791.00
18_L33_G0.9781.00
25_K29_V0.9701.00
31_I35_I0.9541.00
49_L52_R0.9531.00
79_R82_R0.9501.00
21_A32_V0.9421.00
40_F68_S0.9371.00
74_T77_V0.9361.00
5_R78_E0.9361.00
76_V80_K0.9051.00
63_L80_K0.9041.00
10_L39_L0.8801.00
38_V42_A0.8771.00
44_L65_L0.8711.00
21_A25_K0.8621.00
67_A77_V0.8541.00
3_R7_I0.8491.00
72_F76_V0.8451.00
12_G74_T0.8401.00
51_A56_W0.8401.00
23_P26_Y0.8381.00
5_R9_I0.8311.00
4_F43_Y0.8311.00
51_A54_L0.8301.00
22_M32_V0.8261.00
64_A81_L0.8161.00
77_V81_L0.8091.00
18_L21_A0.8041.00
12_G75_F0.7951.00
13_V75_F0.7921.00
4_F8_A0.7911.00
24_L27_L0.7901.00
51_A58_L0.7881.00
44_L48_L0.7801.00
50_L53_R0.7771.00
76_V81_L0.7421.00
46_L49_L0.7301.00
59_K62_L0.7181.00
32_V35_I0.7121.00
67_A74_T0.7091.00
11_E14_S0.7021.00
62_L66_L0.6941.00
24_L28_A0.6921.00
43_Y64_A0.6871.00
11_E39_L0.6871.00
22_M25_K0.6321.00
60_R80_K0.6231.00
51_A57_S0.6121.00
69_L74_T0.6061.00
74_T78_E0.5991.00
63_L77_V0.5781.00
14_S33_G0.5771.00
4_F47_A0.5741.00
15_L19_F0.5741.00
51_A55_R0.5681.00
44_L61_T0.5631.00
62_L65_L0.5601.00
3_R42_A0.5601.00
35_I39_L0.5531.00
21_A24_L0.5491.00
61_T65_L0.5461.00
50_L64_A0.5461.00
8_A67_A0.5391.00
5_R82_R0.5391.00
21_A31_I0.5391.00
18_L29_V0.5361.00
33_G38_V0.5301.00
9_I78_E0.5301.00
15_L74_T0.5221.00
43_Y67_A0.5161.00
50_L56_W0.5151.00
22_M29_V0.5110.99
17_L28_A0.5080.99
55_R59_K0.5030.99
15_L69_L0.5020.99
19_F26_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k44A 1 0.1325 1.3 0.926 Contact Map
4he8M 1 1 1.3 0.927 Contact Map
3rkoM 1 1 1.2 0.929 Contact Map
3rkoN 1 1 1.1 0.929 Contact Map
2xndJ 3 0.3133 1 0.931 Contact Map
4ff5A 1 0 1 0.931 Contact Map
4f4sA 3 0.3253 1 0.932 Contact Map
2qtsA 4 0.3614 1 0.933 Contact Map
1zrvA 1 0.1566 0.9 0.933 Contact Map
2xgrA 1 0.0241 0.9 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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