GREMLIN Database
ThrE_2 - Threonine/Serine exporter, ThrE
PFAM: PF12821 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 130 (126)
Sequences: 13833 (9346)
Seq/√Len: 832.6
META: 0.736

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_V58_V3.2611.00
94_A110_G3.0581.00
11_A28_A2.5331.00
20_P23_D2.5281.00
7_A28_A2.4961.00
34_G59_V2.4461.00
60_G127_A2.4221.00
30_A62_L2.3011.00
102_D105_S2.2371.00
10_A31_G2.1221.00
57_L127_A2.1221.00
7_A32_A2.0971.00
76_V80_P2.0181.00
109_R112_E2.0041.00
91_L113_A1.9361.00
3_V36_L1.9181.00
98_L106_G1.8751.00
14_A24_L1.8571.00
63_A78_I1.8531.00
52_T116_I1.7621.00
14_A19_A1.7541.00
53_F119_A1.7431.00
3_V32_A1.7341.00
77_F80_P1.5991.00
17_F83_I1.5911.00
40_L44_L1.5691.00
97_D109_R1.5301.00
59_V81_G1.5161.00
41_L46_L1.5051.00
6_A35_W1.4771.00
41_L54_L1.4421.00
94_A113_A1.4221.00
30_A66_L1.3801.00
53_F126_L1.3641.00
97_D102_D1.3111.00
36_L40_L1.3061.00
38_R42_L1.2951.00
42_L51_A1.2911.00
60_G124_L1.2841.00
11_A24_L1.2611.00
105_S108_A1.2531.00
33_L62_L1.2431.00
97_D106_G1.2211.00
9_A13_F1.1861.00
39_L43_R1.1671.00
10_A83_I1.1671.00
19_A23_D1.1651.00
30_A81_G1.1491.00
89_V93_R1.1411.00
23_D72_T1.1351.00
34_G55_A1.1341.00
103_L106_G1.1191.00
25_L28_A1.0851.00
37_V41_L1.0751.00
35_W38_R1.0691.00
105_S109_R1.0691.00
106_G109_R1.0681.00
64_N128_S1.0681.00
65_L69_R1.0591.00
123_G127_A1.0321.00
112_E116_I1.0311.00
46_L50_L1.0201.00
21_R24_L1.0171.00
27_A31_G1.0101.00
120_I123_G1.0101.00
107_L111_L1.0001.00
117_A120_I0.9951.00
26_W66_L0.9931.00
19_A27_A0.9931.00
35_W39_L0.9891.00
62_L66_L0.9751.00
112_E115_L0.9661.00
107_L110_G0.9501.00
93_R109_R0.9441.00
56_A120_I0.9411.00
48_P52_T0.9321.00
69_R72_T0.9231.00
26_W29_L0.9141.00
49_F52_T0.9101.00
9_A83_I0.9071.00
90_A113_A0.9051.00
108_A112_E0.9001.00
64_N68_R0.8931.00
8_L12_G0.8861.00
26_W70_L0.8851.00
70_L77_F0.8791.00
4_L8_L0.8691.00
97_D105_S0.8631.00
93_R97_D0.8561.00
96_R100_Q0.8561.00
67_A74_A0.8491.00
72_T77_F0.8471.00
90_A112_E0.8461.00
67_A71_K0.8441.00
4_L7_A0.8321.00
53_F57_L0.8221.00
37_V55_A0.8181.00
41_L51_A0.8091.00
64_N74_A0.8031.00
13_F16_L0.8011.00
12_G15_V0.8001.00
49_F112_E0.7781.00
66_L69_R0.7761.00
40_L43_R0.7751.00
25_L29_L0.7711.00
73_P92_Y0.7681.00
58_V62_L0.7661.00
41_L45_G0.7581.00
82_I120_I0.7521.00
42_L45_G0.7471.00
104_V108_A0.7461.00
64_N127_A0.7341.00
3_V7_A0.7331.00
63_A77_F0.7281.00
114_L118_L0.7211.00
7_A25_L0.7201.00
77_F81_G0.7041.00
83_I86_V0.7001.00
75_T79_V0.6991.00
23_D70_L0.6971.00
21_R25_L0.6931.00
57_L61_L0.6921.00
103_L107_L0.6911.00
46_L54_L0.6891.00
68_R71_K0.6861.00
49_F115_L0.6851.00
14_A27_A0.6831.00
55_A59_V0.6811.00
51_A55_A0.6801.00
54_L57_L0.6791.00
66_L70_L0.6771.00
111_L115_L0.6691.00
94_A106_G0.6681.00
47_G52_T0.6651.00
90_A109_R0.6621.00
74_A79_V0.6611.00
73_P80_P0.6601.00
106_G110_G0.6531.00
110_G114_L0.6521.00
61_L127_A0.6481.00
47_G50_L0.6451.00
33_L58_V0.6441.00
9_A12_G0.6381.00
35_W84_P0.6261.00
36_L39_L0.6251.00
13_F86_V0.6211.00
66_L77_F0.6181.00
31_G84_P0.6111.00
56_A82_I0.6011.00
5_A8_L0.5981.00
96_R99_V0.5981.00
73_P76_V0.5981.00
64_N67_A0.5911.00
6_A10_A0.5821.00
59_V84_P0.5771.00
82_I124_L0.5741.00
93_R96_R0.5701.00
59_V63_A0.5681.00
122_A125_L0.5651.00
74_A80_P0.5581.00
24_L27_A0.5561.00
32_A36_L0.5541.00
110_G128_S0.5541.00
97_D100_Q0.5541.00
75_T80_P0.5531.00
57_L123_G0.5521.00
90_A94_A0.5511.00
11_A15_V0.5501.00
42_L48_P0.5461.00
41_L44_L0.5401.00
46_L51_A0.5391.00
53_F122_A0.5381.00
79_V93_R0.5371.00
37_V40_L0.5351.00
115_L118_L0.5331.00
98_L110_G0.5231.00
106_G115_L0.5191.00
45_G48_P0.5181.00
31_G81_G0.5181.00
67_A70_L0.5171.00
57_L126_L0.5161.00
56_A60_G0.5121.00
125_L128_S0.5081.00
75_T78_I0.5041.00
13_F17_F0.5041.00
18_N92_Y0.5021.00
43_R51_A0.5011.00
33_L37_V0.5011.00
29_L33_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zcdA 1 0.5462 14.4 0.879 Contact Map
2b2hA 3 0.8462 3.8 0.907 Contact Map
3orgA 2 0.9077 3.6 0.909 Contact Map
3hd6A 3 0.7231 2.3 0.917 Contact Map
3nd0A 2 0.9154 1.9 0.921 Contact Map
1ciiA 1 0.3769 1.8 0.922 Contact Map
4o9uB 2 0.9538 1.8 0.922 Contact Map
2k3cA 1 0.2385 1.6 0.925 Contact Map
3b9wA 3 0.9077 1.4 0.927 Contact Map
4o93B 1 0.9538 1.3 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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