GREMLIN Database
Vps8 - Golgi CORVET complex core vacuolar protein 8
PFAM: PF12816 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 188 (187)
Sequences: 611 (468)
Seq/√Len: 34.2
META: 0.34

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_D125_Y4.2111.00
41_E69_A3.8001.00
176_D179_S3.5591.00
79_N135_E3.0591.00
182_S185_N2.8981.00
68_D111_K2.6631.00
14_G46_H2.6031.00
84_P115_Y2.5771.00
163_E168_Y2.5701.00
182_S186_E2.4781.00
155_W163_E2.4371.00
179_S182_S2.3590.99
155_W164_P2.3030.99
120_L125_Y2.2920.99
75_N115_Y2.0810.99
67_Y146_F2.0580.98
4_L27_L2.0460.98
9_P23_V2.0220.98
8_E12_L1.9550.98
166_F186_E1.9350.98
27_L43_I1.9080.97
121_T186_E1.9040.97
66_L125_Y1.8920.97
89_L92_L1.8750.97
9_P12_L1.8510.97
75_N119_C1.8040.96
47_L54_I1.7540.96
81_Y84_P1.7330.95
115_Y119_C1.7230.95
87_E165_S1.7030.95
95_L99_D1.6680.94
2_I43_I1.6540.94
164_P168_Y1.6500.94
155_W168_Y1.6410.94
72_Y75_N1.6060.93
66_L120_L1.5930.93
178_E185_N1.5810.93
180_F183_V1.5100.91
60_L64_H1.4980.90
61_C75_N1.4840.90
159_D174_K1.4700.89
97_G143_I1.4310.88
24_V47_L1.4050.87
165_S170_R1.3740.86
78_L88_L1.3660.86
20_P61_C1.3640.86
109_A113_L1.3590.85
178_E186_E1.3340.84
59_T119_C1.3340.84
46_H74_W1.2880.82
20_P44_I1.2720.81
8_E31_Y1.2660.81
65_N96_N1.2480.80
156_P171_L1.2450.80
156_P168_Y1.2310.79
49_I172_L1.2260.79
41_E45_C1.2200.78
36_R39_R1.2190.78
152_S158_P1.2180.78
18_S48_D1.2080.78
156_P167_P1.2070.78
29_E78_L1.1920.77
21_P28_V1.1750.76
79_N138_K1.1720.76
3_F26_D1.1520.74
45_C54_I1.1410.74
178_E182_S1.1370.73
54_I77_A1.1250.72
60_L132_P1.1250.72
171_L175_F1.1250.72
23_V104_S1.1130.72
165_S172_L1.1120.72
11_I42_E1.1080.71
99_D116_L1.1050.71
154_S157_K1.0950.70
72_Y148_F1.0940.70
125_Y150_G1.0850.70
62_K87_E1.0610.68
50_S142_E1.0600.68
86_E168_Y1.0540.67
23_V29_E1.0530.67
61_C69_A1.0360.66
113_L119_C1.0350.66
136_A139_A1.0340.66
120_L143_I1.0330.66
81_Y179_S1.0270.65
111_K125_Y1.0250.65
45_C69_A1.0240.65
3_F9_P1.0220.65
178_E181_L1.0200.65
144_Y148_F1.0170.65
89_L136_A1.0070.64
86_E155_W0.9990.63
89_L125_Y0.9960.63
113_L156_P0.9910.63
158_P161_D0.9900.62
81_Y92_L0.9890.62
119_C139_A0.9700.61
24_V43_I0.9700.61
6_T10_Y0.9640.60
32_V40_L0.9570.60
48_D104_S0.9570.60
47_L52_L0.9550.60
87_E177_A0.9540.60
55_D143_I0.9530.60
167_P172_L0.9460.59
5_E30_H0.9350.58
44_I72_Y0.9280.57
169_L187_A0.9200.57
80_D83_T0.9170.57
183_V187_A0.9160.56
164_P167_P0.9130.56
14_G73_V0.9080.56
32_V64_H0.8990.55
80_D122_G0.8960.55
59_T98_D0.8900.54
9_P39_R0.8880.54
23_V149_S0.8840.54
31_Y178_E0.8760.53
144_Y187_A0.8730.53
77_A139_A0.8730.53
45_C58_T0.8720.53
53_D126_P0.8720.53
168_Y171_L0.8710.53
22_E79_N0.8700.53
29_E95_L0.8660.52
166_F178_E0.8640.52
88_L115_Y0.8630.52
27_L56_Q0.8580.52
7_L184_L0.8400.50
7_L81_Y0.8370.50
10_Y30_H0.8370.50
164_P171_L0.8330.49
42_E169_L0.8230.49
140_K144_Y0.8200.48
112_L172_L0.8170.48
31_Y185_N0.8160.48
46_H77_A0.8150.48
154_S175_F0.8120.48
23_V170_R0.8080.47
118_Y121_T0.8060.47
71_I88_L0.8040.47
20_P149_S0.8040.47
4_L170_R0.7980.46
85_L143_I0.7980.46
132_P179_S0.7970.46
44_I180_F0.7970.46
179_S187_A0.7940.46
12_L181_L0.7940.46
55_D59_T0.7870.46
99_D107_Y0.7850.45
91_L149_S0.7820.45
131_L139_A0.7800.45
121_T140_K0.7770.45
96_N100_E0.7760.45
68_D180_F0.7760.45
24_V55_D0.7750.45
69_A187_A0.7690.44
38_S89_L0.7660.44
66_L144_Y0.7640.44
46_H181_L0.7610.43
50_S184_L0.7600.43
159_D162_D0.7590.43
144_Y180_F0.7550.43
109_A139_A0.7530.43
75_N83_T0.7520.43
5_E75_N0.7500.42
59_T100_E0.7500.42
138_K141_A0.7490.42
12_L126_P0.7430.42
132_P135_E0.7410.42
55_D75_N0.7370.41
106_E143_I0.7370.41
25_K56_Q0.7350.41
9_P69_A0.7320.41
49_I52_L0.7280.41
19_L130_P0.7260.40
129_E180_F0.7250.40
159_D171_L0.7220.40
21_P140_K0.7200.40
41_E61_C0.7130.39
73_V165_S0.7100.39
75_N84_P0.7090.39
6_T25_K0.7030.39
8_E46_H0.7000.38
70_L156_P0.6980.38
60_L88_L0.6920.38
40_L58_T0.6830.37
14_G157_K0.6800.37
138_K174_K0.6780.37
152_S160_G0.6690.36
150_G164_P0.6660.36
87_E147_L0.6630.35
25_K54_I0.6620.35
23_V52_L0.6620.35
43_I49_I0.6590.35
166_F182_S0.6530.35
74_W77_A0.6520.35
43_I54_I0.6500.34
47_L74_W0.6500.34
114_P125_Y0.6460.34
35_G99_D0.6460.34
128_G177_A0.6440.34
80_D173_L0.6440.34
163_E166_F0.6440.34
21_P123_R0.6430.34
155_W171_L0.6430.34
28_V60_L0.6420.34
109_A175_F0.6350.33
15_K29_E0.6350.33
16_I65_N0.6340.33
25_K60_L0.6310.33
42_E74_W0.6300.33
42_E45_C0.6270.33
166_F177_A0.6270.33
100_E105_K0.6160.32
160_G165_S0.6140.32
173_L180_F0.6140.32
19_L34_K0.6130.32
4_L56_Q0.6120.32
17_T74_W0.6090.31
13_D59_T0.6070.31
169_L175_F0.6050.31
54_I135_E0.6020.31
4_L24_V0.6020.31
54_I68_D0.6020.31
143_I152_S0.5990.31
47_L85_L0.5960.30
151_R154_S0.5950.30
52_L167_P0.5950.30
9_P47_L0.5940.30
2_I27_L0.5910.30
169_L177_A0.5910.30
119_C148_F0.5910.30
110_Y113_L0.5900.30
103_E147_L0.5900.30
81_Y144_Y0.5890.30
7_L102_E0.5850.30
85_L116_L0.5850.30
24_V40_L0.5770.29
49_I124_A0.5760.29
56_Q69_A0.5730.29
48_D64_H0.5710.29
156_P164_P0.5690.29
158_P164_P0.5690.29
28_V54_I0.5670.28
4_L77_A0.5610.28
16_I55_D0.5580.28
56_Q77_A0.5570.28
39_R88_L0.5570.28
113_L182_S0.5570.28
34_K96_N0.5560.28
124_A172_L0.5510.27
42_E111_K0.5500.27
15_K77_A0.5480.27
48_D147_L0.5440.27
24_V39_R0.5400.27
25_K123_R0.5390.27
65_N71_I0.5390.27
164_P169_L0.5370.26
178_E187_A0.5340.26
45_C73_V0.5330.26
45_C178_E0.5330.26
28_V64_H0.5330.26
29_E98_D0.5240.26
153_I184_L0.5240.26
4_L31_Y0.5240.26
14_G24_V0.5230.25
5_E35_G0.5210.25
44_I103_E0.5210.25
83_T139_A0.5180.25
73_V125_Y0.5140.25
31_Y57_V0.5130.25
47_L64_H0.5070.24
98_D101_L0.5060.24
44_I119_C0.5050.24
67_Y88_L0.5030.24
79_N106_E0.5030.24
131_L182_S0.5020.24
127_T130_P0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lvgA 3 0.9096 76 0.914 Contact Map
1xi4A 8 0.5266 32.6 0.935 Contact Map
3qilA 3 0.4947 23.3 0.94 Contact Map
1xg7A 2 0.8085 21.5 0.941 Contact Map
4x3iA 1 0.1223 4.6 0.956 Contact Map
4cr2S 1 0.9521 4.3 0.957 Contact Map
3fgaB 2 0.9149 3.4 0.959 Contact Map
4kmoB 1 0.266 3.4 0.959 Contact Map
4yczB 1 0.8298 3.3 0.959 Contact Map
4w60A 1 0.1436 3.3 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0071 seconds.