GREMLIN Database
Gly_rich - Glycine rich protein
PFAM: PF12810 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 243 (223)
Sequences: 3195 (2907)
Seq/√Len: 194.7
META: 0.829

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_S155_Q3.9091.00
90_D100_R3.2581.00
17_W36_Y3.1461.00
89_T233_A3.1461.00
15_E38_S3.1321.00
15_E36_Y3.1281.00
51_I233_A3.0661.00
92_R100_R3.0301.00
13_K38_S2.7841.00
55_G69_G2.7611.00
153_F174_Y2.5891.00
37_S192_S2.5821.00
94_G98_S2.5491.00
97_L100_R2.5101.00
14_I91_I2.3941.00
13_K40_T2.2151.00
94_G99_S2.1141.00
197_S215_T2.0461.00
195_G198_T2.0451.00
20_Q33_K2.0401.00
218_I221_N2.0091.00
106_G172_G1.9671.00
127_N137_G1.9381.00
35_G122_G1.9251.00
227_N232_Y1.9171.00
23_G31_G1.8981.00
20_Q31_G1.8701.00
119_A126_G1.8281.00
88_A92_R1.8251.00
92_R97_L1.8101.00
7_P46_G1.7841.00
35_G192_S1.7771.00
11_T42_T1.7581.00
35_G105_G1.7581.00
37_S102_I1.7441.00
16_V91_I1.7231.00
137_G146_A1.6641.00
11_T40_T1.6621.00
16_V233_A1.6351.00
44_T47_T1.6211.00
20_Q227_N1.6051.00
52_Y90_D1.5621.00
40_T214_N1.5551.00
52_Y70_Y1.5511.00
175_Y191_S1.5451.00
69_G84_G1.5421.00
100_R103_V1.5341.00
66_G84_G1.5291.00
17_W232_Y1.5191.00
32_G107_G1.5041.00
14_I49_L1.5011.00
37_S217_T1.4931.00
20_Q56_Q1.4871.00
20_Q228_S1.4631.00
155_Q158_N1.4511.00
16_V102_I1.4471.00
31_G110_G1.4451.00
90_D97_L1.4381.00
49_L91_I1.4331.00
16_V104_A1.4061.00
205_T211_Y1.3951.00
88_A103_V1.3761.00
206_H209_G1.3551.00
9_T46_G1.3301.00
20_Q229_G1.3231.00
140_T143_A1.3171.00
71_N90_D1.2931.00
72_G88_A1.2891.00
57_G84_G1.2811.00
15_E234_R1.2731.00
52_Y92_R1.2641.00
105_G192_S1.2641.00
24_G83_G1.2581.00
15_E236_T1.2581.00
204_S207_Y1.2531.00
193_Y196_G1.2441.00
96_S99_S1.2431.00
93_G100_R1.2191.00
57_G83_G1.2181.00
71_N88_A1.2161.00
102_I194_I1.2031.00
94_G97_L1.2021.00
122_G192_S1.1761.00
52_Y100_R1.1601.00
93_G97_L1.1591.00
13_K238_L1.1511.00
95_T98_S1.1401.00
33_K119_A1.1391.00
12_Y43_L1.1381.00
33_K228_S1.1271.00
24_G110_G1.1041.00
56_Q59_S1.1011.00
123_L141_Q1.1001.00
58_G84_G1.0961.00
194_I197_S1.0811.00
139_G188_G1.0721.00
17_W37_S1.0671.00
9_T44_T1.0661.00
217_T221_N1.0661.00
153_F157_G1.0571.00
156_G176_G1.0541.00
91_I233_A1.0461.00
14_I233_A1.0421.00
194_I215_T1.0301.00
55_G71_N1.0141.00
188_G191_S1.0131.00
37_S194_I1.0111.00
127_N138_G1.0091.00
136_G188_G1.0071.00
137_G188_G1.0011.00
145_G157_G0.9891.00
95_T99_S0.9800.99
105_G139_G0.9780.99
22_G57_G0.9770.99
39_G198_T0.9760.99
94_G100_R0.9680.99
93_G101_I0.9640.99
55_G68_G0.9630.99
93_G98_S0.9570.99
88_A100_R0.9550.99
206_H212_F0.9550.99
195_G212_F0.9340.99
16_V37_S0.9290.99
227_N234_R0.9280.99
41_I101_I0.9160.99
22_G109_G0.9090.99
109_G169_G0.9080.99
193_Y204_S0.9030.99
23_G59_S0.8960.99
17_W234_R0.8920.99
216_S219_A0.8890.99
11_T238_L0.8860.99
118_G186_G0.8800.99
7_P12_Y0.8770.99
204_S209_G0.8750.99
90_D103_V0.8750.99
7_P47_T0.8750.99
172_G176_G0.8740.99
204_S211_Y0.8730.99
7_P43_L0.8720.99
43_L49_L0.8720.99
8_P11_T0.8700.99
125_G141_Q0.8660.99
118_G128_G0.8650.99
8_P237_Y0.8620.99
7_P45_P0.8590.99
139_G143_A0.8540.99
194_I217_T0.8530.99
123_L192_S0.8490.98
71_N92_R0.8460.98
202_G207_Y0.8450.98
153_F156_G0.8450.98
202_G205_T0.8450.98
203_G206_H0.8420.98
203_G207_Y0.8380.98
108_G186_G0.8330.98
233_A237_Y0.8330.98
52_Y97_L0.8330.98
207_Y210_Y0.8300.98
187_G190_G0.8260.98
97_L154_G0.8160.98
88_A172_G0.8110.98
52_Y95_T0.8100.98
154_G157_G0.8100.98
117_G186_G0.8100.98
31_G107_G0.7970.98
53_V89_T0.7910.98
9_T42_T0.7900.98
39_G197_S0.7880.98
119_A221_N0.7880.98
19_A55_G0.7860.97
175_Y192_S0.7860.97
47_T210_Y0.7850.97
32_G117_G0.7820.97
196_G212_F0.7810.97
124_T127_N0.7810.97
51_I91_I0.7770.97
221_N232_Y0.7730.97
108_G189_G0.7680.97
220_G227_N0.7640.97
204_S210_Y0.7600.97
49_L101_I0.7570.97
39_G102_I0.7560.97
19_A57_G0.7540.97
7_P11_T0.7510.97
206_H211_Y0.7470.97
204_S208_S0.7440.97
93_G99_S0.7370.96
35_G191_S0.7350.96
125_G128_G0.7340.96
30_T116_N0.7330.96
204_S212_F0.7320.96
215_T218_I0.7310.96
70_Y74_G0.7280.96
88_A97_L0.7270.96
14_I235_I0.7260.96
68_G84_G0.7260.96
232_Y236_T0.7240.96
93_G96_S0.7230.96
83_G109_G0.7210.96
156_G159_G0.7170.96
9_T43_L0.7160.96
171_G175_Y0.7130.96
9_T12_Y0.7110.95
98_S174_Y0.7110.95
138_G188_G0.7080.95
169_G172_G0.7060.95
22_G59_S0.7020.95
55_G230_N0.7010.95
192_S195_G0.6990.95
56_Q230_N0.6980.95
125_G139_G0.6930.95
30_T33_K0.6890.95
168_G187_G0.6880.95
72_G172_G0.6860.95
174_Y206_H0.6800.94
96_S100_R0.6760.94
193_Y203_G0.6720.94
33_K56_Q0.6720.94
171_G174_Y0.6710.94
126_G219_A0.6710.94
85_G169_G0.6710.94
108_G187_G0.6700.94
70_Y90_D0.6660.94
40_T238_L0.6640.94
144_G152_S0.6640.94
100_R174_Y0.6610.93
138_G141_Q0.6600.93
205_T208_S0.6600.93
21_G107_G0.6560.93
206_H210_Y0.6530.93
221_N227_N0.6500.93
70_Y88_A0.6490.93
195_G206_H0.6450.93
84_G169_G0.6390.92
38_S216_S0.6390.92
140_T144_G0.6370.92
143_A146_A0.6360.92
116_N119_A0.6330.92
174_Y193_Y0.6330.92
70_Y87_G0.6330.92
216_S221_N0.6320.92
92_R103_V0.6300.92
137_G147_G0.6290.92
10_G238_L0.6280.92
52_Y71_N0.6280.92
218_I227_N0.6280.92
234_R237_Y0.6250.91
121_G191_S0.6240.91
215_T219_A0.6240.91
175_Y202_G0.6240.91
181_G184_G0.6230.91
195_G204_S0.6210.91
50_Y94_G0.6200.91
88_A154_G0.6200.91
39_G195_G0.6180.91
179_G182_G0.6180.91
208_S211_Y0.6140.91
203_G210_Y0.6130.91
80_G184_G0.6060.90
71_N74_G0.6060.90
43_L46_G0.5990.90
7_P10_G0.5990.90
205_T209_G0.5990.90
57_G60_G0.5980.89
39_G196_G0.5980.89
202_G206_H0.5970.89
203_G208_S0.5960.89
21_G86_G0.5930.89
90_D94_G0.5920.89
169_G187_G0.5860.88
31_G117_G0.5860.88
173_G177_G0.5840.88
9_T45_P0.5810.88
124_T141_Q0.5800.88
18_G21_G0.5740.87
126_G129_G0.5730.87
43_L47_T0.5710.87
95_T100_R0.5710.87
94_G101_I0.5710.87
32_G110_G0.5700.87
55_G87_G0.5690.87
193_Y197_S0.5690.87
207_Y212_F0.5680.87
108_G118_G0.5660.87
141_Q145_G0.5650.87
42_T47_T0.5620.86
197_S212_F0.5600.86
131_G135_G0.5600.86
46_G49_L0.5580.86
170_G177_G0.5560.86
130_S136_G0.5510.85
203_G213_T0.5490.85
72_G90_D0.5480.85
209_G212_F0.5480.85
35_G125_G0.5480.85
125_G138_G0.5470.85
175_Y188_G0.5470.85
148_G185_G0.5460.85
58_G68_G0.5440.85
7_P16_V0.5390.84
125_G188_G0.5370.84
211_Y214_N0.5360.84
202_G209_G0.5360.84
194_I198_T0.5360.84
29_G110_G0.5330.83
23_G83_G0.5300.83
23_G30_T0.5290.83
14_I212_F0.5290.83
23_G110_G0.5290.83
22_G31_G0.5260.83
17_W56_Q0.5250.82
129_G136_G0.5220.82
234_R238_L0.5220.82
153_F158_N0.5210.82
180_G183_G0.5200.82
50_Y95_T0.5200.82
205_T212_F0.5190.82
139_G145_G0.5170.81
20_Q23_G0.5160.81
213_T218_I0.5150.81
7_P237_Y0.5150.81
10_G237_Y0.5140.81
130_S182_G0.5140.81
60_G83_G0.5140.81
47_T198_T0.5120.81
74_G158_N0.5120.81
21_G32_G0.5070.80
8_P45_P0.5070.80
97_L103_V0.5060.80
10_G45_P0.5060.80
141_Q144_G0.5050.80
153_F175_Y0.5010.79
214_N217_T0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dzgA 1 0.1523 11.7 0.94 Contact Map
2cqkA 1 0.2346 4.1 0.951 Contact Map
4douA 1 0.3292 3.9 0.952 Contact Map
4g9sB 1 0.1564 3.6 0.953 Contact Map
1o91A 3 0.3251 3.6 0.953 Contact Map
2wnvC 1 0.3169 3.2 0.954 Contact Map
2eeaA 1 0.1605 3.1 0.954 Contact Map
3sk7A 1 0.1399 3.1 0.954 Contact Map
1j3eA 1 0.1399 3 0.954 Contact Map
4qqhA 3 0.3169 2.7 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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