GREMLIN Database
eIF3_p135 - Translation initiation factor eIF3 subunit 135
PFAM: PF12807 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 172 (165)
Sequences: 715 (519)
Seq/√Len: 40.4
META: 0.278

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_M131_V7.9561.00
11_T21_M4.6831.00
78_H82_C4.2511.00
55_A131_V3.9471.00
80_L154_L3.4481.00
132_K138_E3.0741.00
56_A79_F3.0511.00
14_L21_M2.8491.00
53_A153_L2.5161.00
130_E134_R2.5011.00
28_A137_Y2.2571.00
20_N23_Y2.0500.99
15_H18_G2.0230.99
21_M135_Y1.9570.99
110_E113_F1.8230.98
24_L119_T1.8200.98
60_L157_L1.7980.98
59_I127_I1.7220.97
10_L19_I1.6990.97
76_I158_C1.6850.97
51_M55_A1.6590.96
60_L79_F1.6370.96
4_P46_L1.6240.96
7_G10_L1.6120.96
27_V44_Q1.5740.95
83_L123_L1.5660.95
148_L169_D1.5200.94
49_Q149_R1.4750.93
28_A51_M1.4750.93
84_L154_L1.4640.93
19_I23_Y1.4490.92
11_T50_E1.4460.92
149_R152_Q1.4200.92
18_G22_R1.4050.91
56_A60_L1.3930.91
105_K110_E1.3850.91
156_E159_L1.3780.90
50_E54_R1.3770.90
21_M24_L1.3560.90
7_G58_H1.3320.89
13_L19_I1.3230.89
60_L139_L1.2970.88
17_R40_L1.2940.87
75_A82_C1.2800.87
58_H134_R1.2790.87
157_L165_L1.2500.86
84_L157_L1.2430.85
142_D145_D1.2310.85
28_A131_V1.2260.84
14_L140_P1.2130.84
100_L104_Y1.2110.84
104_Y135_Y1.1850.82
82_C119_T1.1760.82
7_G50_E1.1760.82
156_E160_K1.1540.81
78_H120_P1.1340.79
40_L44_Q1.1330.79
85_G161_V1.1310.79
40_L43_L1.1270.79
78_H115_F1.1190.78
80_L165_L1.0960.77
4_P10_L1.0940.77
55_A135_Y1.0860.76
26_K163_I1.0850.76
5_M14_L1.0780.76
152_Q167_A1.0780.76
11_T160_K1.0740.76
32_A135_Y1.0670.75
41_P45_S1.0610.75
58_H130_E1.0500.74
27_V63_Y1.0340.73
2_L13_L1.0330.73
62_A66_S1.0310.72
68_P71_F1.0210.72
4_P162_G1.0170.71
10_L46_L1.0100.71
129_E141_E1.0080.71
59_I126_E1.0040.70
80_L157_L1.0020.70
7_G160_K1.0010.70
105_K135_Y1.0010.70
15_H20_N0.9940.70
41_P52_I0.9860.69
27_V147_S0.9670.68
89_N92_P0.9590.67
100_L163_I0.9540.66
15_H22_R0.9540.66
158_C163_I0.9500.66
52_I144_I0.9490.66
43_L128_E0.9480.66
53_A83_L0.9410.65
19_I122_S0.9390.65
46_L155_R0.9310.65
154_L165_L0.9190.64
75_A78_H0.9170.63
62_A126_E0.8970.62
53_A160_K0.8900.61
68_P111_A0.8870.61
82_C115_F0.8770.60
60_L161_V0.8770.60
131_V136_R0.8740.60
158_C161_V0.8710.59
10_L160_K0.8660.59
26_K29_E0.8490.57
9_T154_L0.8380.56
135_Y139_L0.8380.56
77_A96_I0.8380.56
2_L42_H0.8360.56
55_A58_H0.8160.54
116_E135_Y0.8060.53
74_A89_N0.8050.53
69_A135_Y0.8030.53
52_I76_I0.8030.53
123_L127_I0.8020.53
14_L27_V0.7860.52
129_E168_R0.7830.51
54_R57_K0.7820.51
5_M9_T0.7810.51
62_A128_E0.7740.51
3_S39_R0.7740.51
125_K128_E0.7730.50
63_Y79_F0.7700.50
86_S112_D0.7600.49
7_G130_E0.7600.49
26_K30_L0.7590.49
156_E164_Q0.7590.49
119_T164_Q0.7580.49
149_R167_A0.7510.48
21_M154_L0.7510.48
88_L148_L0.7480.48
7_G14_L0.7450.48
46_L51_M0.7430.48
141_E148_L0.7410.47
131_V148_L0.7390.47
23_Y78_H0.7380.47
18_G25_G0.7360.47
47_C159_L0.7360.47
115_F134_R0.7350.47
68_P115_F0.7280.46
31_A35_P0.7260.46
22_R82_C0.7260.46
3_S30_L0.7240.46
153_L166_V0.7220.46
65_R145_D0.7210.46
153_L161_V0.7190.45
21_M117_K0.7180.45
145_D163_I0.7170.45
154_L172_F0.7170.45
9_T13_L0.7170.45
22_R25_G0.7160.45
52_I170_Y0.7150.45
50_E160_K0.7140.45
166_V170_Y0.7110.45
78_H119_T0.7070.44
100_L103_L0.7060.44
96_I135_Y0.7060.44
65_R115_F0.6990.44
101_K104_Y0.6970.43
81_N85_G0.6930.43
85_G155_R0.6920.43
41_P44_Q0.6870.43
12_E38_E0.6860.42
152_Q163_I0.6830.42
74_A172_F0.6810.42
28_A68_P0.6770.42
45_S66_S0.6760.42
127_I158_C0.6750.41
40_L64_L0.6740.41
76_I81_N0.6730.41
27_V70_P0.6720.41
9_T156_E0.6700.41
62_A129_E0.6690.41
43_L132_K0.6640.40
9_T76_I0.6600.40
80_L163_I0.6580.40
39_R61_R0.6580.40
51_M154_L0.6540.40
104_Y110_E0.6530.40
82_C164_Q0.6480.39
119_T123_L0.6450.39
73_A124_W0.6410.38
39_R43_L0.6390.38
71_F113_F0.6350.38
7_G89_N0.6330.38
11_T171_D0.6310.38
5_M17_R0.6310.38
105_K169_D0.6230.37
78_H83_L0.6230.37
22_R79_F0.6210.37
45_S150_K0.6190.37
28_A47_C0.6180.36
61_R158_C0.6130.36
88_L168_R0.6120.36
15_H54_R0.6120.36
46_L98_E0.6090.36
81_N118_L0.6040.35
62_A98_E0.5980.35
53_A157_L0.5960.35
138_E170_Y0.5940.34
59_I168_R0.5940.34
20_N25_G0.5940.34
114_S142_D0.5910.34
24_L55_A0.5900.34
93_K158_C0.5900.34
136_R139_L0.5900.34
59_I123_L0.5870.34
7_G85_G0.5870.34
2_L46_L0.5810.33
30_L158_C0.5790.33
117_K140_P0.5780.33
127_I131_V0.5770.33
125_K129_E0.5770.33
80_L158_C0.5760.33
61_R135_Y0.5660.32
5_M75_A0.5640.32
8_Q12_E0.5630.32
14_L127_I0.5620.32
129_E133_K0.5620.32
91_K111_A0.5610.32
124_W143_W0.5610.32
63_Y76_I0.5580.32
118_L123_L0.5540.31
7_G11_T0.5530.31
143_W165_L0.5470.31
71_F96_I0.5460.31
41_P130_E0.5440.30
7_G17_R0.5370.30
115_F167_A0.5360.30
83_L134_R0.5350.30
19_I22_R0.5320.29
28_A48_I0.5300.29
155_R158_C0.5300.29
9_T135_Y0.5270.29
3_S60_L0.5260.29
20_N54_R0.5260.29
7_G73_A0.5250.29
88_L133_K0.5230.29
37_S124_W0.5220.29
130_E133_K0.5180.28
131_V152_Q0.5160.28
33_K86_S0.5130.28
19_I137_Y0.5120.28
82_C120_P0.5110.28
87_S150_K0.5040.27
3_S61_R0.5030.27
144_I170_Y0.5030.27
46_L140_P0.5000.27
55_A78_H0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q6rA 2 0.4535 14.4 0.944 Contact Map
3gxvA 4 0.3779 13.3 0.945 Contact Map
3j7yh 1 0.3314 13.3 0.945 Contact Map
3epzA 1 0.7791 12.6 0.945 Contact Map
3ejbA 1 0.3198 9.5 0.948 Contact Map
2r5uA 5 0.4884 9.2 0.948 Contact Map
4a6rA 2 0.3779 8.8 0.949 Contact Map
4a0gA 2 0.3198 8 0.95 Contact Map
1klpA 1 0.3314 7.9 0.95 Contact Map
4w8iA 2 0.3081 7.4 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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