GREMLIN Database
FUSC-like - FUSC-like inner membrane protein yccS
PFAM: PF12805 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 284 (276)
Sequences: 2511 (1786)
Seq/√Len: 107.5
META: 0.634

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_R223_R5.5891.00
131_L134_L4.3671.00
131_L135_R3.3441.00
15_L29_L3.0911.00
113_A223_R3.0601.00
210_R251_A2.9271.00
129_D134_L2.9131.00
130_D135_R2.8431.00
35_F39_M2.7711.00
130_D134_L2.7601.00
76_L80_A2.7231.00
113_A219_A2.6101.00
263_N266_L2.5921.00
130_D133_A2.5541.00
263_N269_A2.5011.00
129_D135_R2.4621.00
246_E250_A2.3191.00
24_W28_L2.2961.00
266_L269_A2.2841.00
217_L244_A2.2231.00
166_Q169_G2.2071.00
4_I8_C2.1111.00
249_E253_E2.0651.00
5_T8_C2.0631.00
109_L112_L2.0311.00
104_A155_L2.0161.00
29_L33_L2.0011.00
117_R220_D1.9731.00
269_A276_N1.9211.00
167_P170_R1.9091.00
5_T9_F1.9041.00
261_P265_E1.8811.00
167_P172_R1.8471.00
264_R267_L1.8121.00
83_L87_L1.8081.00
121_A137_A1.7881.00
106_A226_A1.7521.00
272_A276_N1.7011.00
212_Q216_R1.6901.00
268_I271_R1.6681.00
134_L137_A1.6661.00
12_A33_L1.6531.00
272_A275_R1.6351.00
71_A75_A1.6231.00
110_R226_A1.6041.00
169_G172_R1.5961.00
179_L182_V1.5651.00
271_R275_R1.5511.00
263_N268_I1.5371.00
120_A216_R1.5321.00
263_N267_L1.5151.00
268_I272_A1.5151.00
45_Q48_A1.5021.00
265_E269_A1.4891.00
261_P264_R1.4831.00
110_R230_L1.4771.00
19_L29_L1.4721.00
4_I9_F1.4631.00
249_E278_R1.4431.00
153_R182_V1.4261.00
242_E246_E1.3891.00
115_Y185_F1.3641.00
267_L270_L1.3571.00
154_E158_K1.3551.00
199_R203_G1.3511.00
209_F213_R1.3491.00
196_E200_E1.3431.00
273_L276_N1.3421.00
259_D263_N1.3411.00
133_A136_L1.3360.99
85_Y186_E1.3350.99
179_L183_D1.3300.99
109_L181_A1.3290.99
182_V185_F1.3280.99
18_L71_A1.3250.99
111_A141_Q1.3220.99
16_V26_L1.3190.99
267_L275_R1.3140.99
141_Q144_A1.3120.99
52_F56_L1.3080.99
19_L25_L1.3070.99
4_I10_A1.3040.99
3_L8_C1.2830.99
263_N276_N1.2730.99
43_Y47_A1.2730.99
270_L276_N1.2650.99
74_H115_Y1.2490.99
4_I7_L1.2440.99
261_P269_A1.2320.99
266_L270_L1.2320.99
272_A278_R1.2230.99
3_L6_L1.2190.99
265_E268_I1.2110.99
256_R264_R1.2110.99
108_C112_L1.1990.99
111_A114_D1.1810.99
274_L279_T1.1800.99
168_T171_S1.1760.99
114_D141_Q1.1610.99
18_L21_P1.1470.98
107_E148_A1.1460.98
6_L9_F1.1390.98
269_A278_R1.1380.98
264_R268_I1.1360.98
41_G48_A1.1350.98
246_E249_E1.1290.98
13_A75_A1.1270.98
160_R164_R1.1260.98
269_A279_T1.1200.98
26_L30_L1.1190.98
256_R271_R1.1180.98
33_L37_F1.1170.98
22_Y25_L1.1070.98
119_K138_L1.1050.98
125_P129_D1.1000.98
264_R271_R1.0980.98
261_P271_R1.0980.98
213_R217_L1.0970.98
195_Y202_F1.0910.98
127_R130_D1.0900.98
260_N271_R1.0860.98
129_D133_A1.0860.98
262_E265_E1.0830.98
175_L179_L1.0810.98
183_D186_E1.0790.98
256_R267_L1.0780.98
44_G47_A1.0690.98
153_R194_D1.0670.98
10_A75_A1.0640.97
37_F54_A1.0540.97
251_A255_L1.0520.97
265_E271_R1.0480.97
69_P73_L1.0370.97
263_N270_L1.0250.97
118_A141_Q1.0230.97
73_L76_L1.0150.97
191_S198_L1.0080.96
167_P171_S1.0010.96
240_D243_A0.9990.96
10_A14_L0.9980.96
188_A192_H0.9970.96
266_L272_A0.9940.96
7_L11_L0.9880.96
247_A254_E0.9820.96
17_G75_A0.9800.96
265_E274_L0.9800.96
36_L40_L0.9770.96
259_D265_E0.9750.96
111_A148_A0.9720.96
260_N263_N0.9670.96
256_R259_D0.9660.96
259_D264_R0.9660.96
166_Q170_R0.9650.95
218_L222_L0.9550.95
7_L10_A0.9550.95
267_L271_R0.9450.95
48_A52_F0.9430.95
103_Q230_L0.9420.95
251_A254_E0.9420.95
150_E153_R0.9380.95
271_R278_R0.9290.94
111_A226_A0.9270.94
243_A250_A0.9180.94
131_L137_A0.9120.94
128_E134_L0.9070.94
85_Y94_P0.8960.93
17_G71_A0.8930.93
117_R216_R0.8910.93
265_E276_N0.8880.93
254_E257_A0.8820.93
178_F182_V0.8740.92
82_G221_E0.8740.92
261_P273_L0.8730.92
164_R169_G0.8720.92
263_N274_L0.8640.92
272_A277_L0.8620.92
6_L10_A0.8610.92
68_G71_A0.8600.92
62_M273_L0.8600.92
15_L20_F0.8600.92
113_A117_R0.8580.92
250_A253_E0.8570.92
268_I274_L0.8560.92
266_L278_R0.8540.92
68_G76_L0.8530.92
240_D244_A0.8510.91
253_E275_R0.8510.91
206_D209_F0.8510.91
85_Y119_K0.8510.91
266_L276_N0.8500.91
268_I278_R0.8500.91
178_F185_F0.8470.91
227_L230_L0.8470.91
32_L36_L0.8460.91
250_A254_E0.8460.91
5_T50_I0.8410.91
259_D270_L0.8390.91
14_L18_L0.8370.91
200_E203_G0.8360.91
274_L278_R0.8340.91
265_E273_L0.8340.91
267_L274_L0.8280.90
117_R219_A0.8250.90
186_E202_F0.8240.90
267_L272_A0.8190.90
242_E255_L0.8170.90
27_G30_L0.8140.90
263_N273_L0.8050.89
39_M193_Y0.7980.89
202_F222_L0.7980.89
3_L76_L0.7940.88
239_P244_A0.7930.88
51_G98_Y0.7930.88
3_L7_L0.7900.88
238_S241_L0.7860.88
139_A142_Q0.7860.88
269_A273_L0.7860.88
264_R269_A0.7850.88
109_L179_L0.7820.88
13_A57_I0.7820.88
266_L277_L0.7810.87
56_L74_H0.7810.87
54_A204_H0.7790.87
267_L279_T0.7780.87
259_D273_L0.7760.87
266_L275_R0.7750.87
3_L9_F0.7750.87
46_R85_Y0.7710.87
271_R276_N0.7690.87
264_R273_L0.7680.87
256_R265_E0.7680.87
108_C156_L0.7640.86
268_I275_R0.7640.86
191_S195_Y0.7630.86
119_K186_E0.7630.86
77_L88_L0.7620.86
188_A212_Q0.7590.86
243_A246_E0.7570.86
12_A15_L0.7540.86
243_A247_A0.7530.86
14_L75_A0.7520.85
18_L26_L0.7500.85
165_G169_G0.7470.85
198_L228_A0.7450.85
21_P25_L0.7430.85
238_S242_E0.7410.85
244_A247_A0.7410.85
273_L277_L0.7390.84
239_P243_A0.7370.84
263_N275_R0.7320.84
80_A84_W0.7300.84
267_L278_R0.7300.84
90_L97_P0.7300.84
270_L273_L0.7290.84
252_L267_L0.7280.84
190_A199_R0.7240.83
55_L59_V0.7210.83
47_A51_G0.7160.83
85_Y183_D0.7160.83
244_A254_E0.7140.82
119_K195_Y0.7140.82
202_F207_V0.7140.82
174_L180_D0.7140.82
193_Y197_L0.7120.82
273_L278_R0.7090.82
253_E259_D0.7070.82
84_W88_L0.7060.82
251_A257_A0.7060.82
145_V156_L0.7050.82
82_G86_L0.7040.81
19_L23_P0.7020.81
97_P156_L0.7000.81
186_E190_A0.6990.81
84_W97_P0.6970.81
25_L28_L0.6940.81
258_Q262_E0.6940.81
119_K123_Y0.6920.80
119_K191_S0.6900.80
159_R162_V0.6880.80
252_L271_R0.6880.80
258_Q263_N0.6870.80
28_L32_L0.6860.80
57_I179_L0.6840.80
262_E270_L0.6830.80
163_K166_Q0.6820.79
259_D262_E0.6820.79
9_F13_A0.6790.79
265_E272_A0.6780.79
117_R121_A0.6740.79
5_T86_L0.6720.78
72_L76_L0.6710.78
53_A138_L0.6690.78
197_L200_E0.6690.78
11_L15_L0.6680.78
213_R236_Q0.6640.78
54_A58_M0.6620.77
47_A185_F0.6600.77
78_L115_Y0.6590.77
174_L190_A0.6580.77
258_Q265_E0.6560.77
87_L91_L0.6540.77
259_D275_R0.6540.77
179_L218_L0.6500.76
229_I233_R0.6480.76
28_L31_A0.6470.76
77_L186_E0.6410.75
52_F55_L0.6400.75
187_R192_H0.6370.75
108_C153_R0.6350.74
202_F205_S0.6330.74
24_W37_F0.6320.74
93_H230_L0.6310.74
237_H252_L0.6300.74
116_L119_K0.6300.74
18_L22_Y0.6280.74
194_D197_L0.6190.73
12_A29_L0.6190.73
160_R176_L0.6180.72
189_L192_H0.6170.72
61_T86_L0.6140.72
160_R167_P0.6140.72
264_R279_T0.6130.72
101_V175_L0.6110.72
262_E268_I0.6110.72
30_L208_L0.6100.71
14_L71_A0.6080.71
16_V20_F0.6080.71
15_L31_A0.6070.71
64_G67_P0.6060.71
269_A272_A0.6050.71
269_A275_R0.6030.71
64_G74_H0.6000.70
252_L256_R0.6000.70
101_V159_R0.5990.70
262_E275_R0.5960.70
68_G115_Y0.5960.70
248_L252_L0.5940.69
142_Q182_V0.5930.69
257_A261_P0.5900.69
162_V165_G0.5870.69
180_D192_H0.5850.68
61_T74_H0.5850.68
85_Y93_H0.5840.68
122_L195_Y0.5840.68
175_L178_F0.5810.68
195_Y198_L0.5810.68
34_T42_V0.5800.68
234_P246_E0.5770.67
178_F183_D0.5750.67
32_L106_A0.5750.67
174_L178_F0.5750.67
102_Q232_G0.5730.67
220_D224_A0.5720.67
120_A219_A0.5710.66
267_L276_N0.5700.66
17_G20_F0.5690.66
108_C181_A0.5660.66
54_A57_I0.5650.66
34_T58_M0.5580.65
60_L64_G0.5570.65
128_E132_E0.5560.64
152_A169_G0.5540.64
50_I55_L0.5530.64
63_A66_G0.5530.64
89_S175_L0.5520.64
120_A194_D0.5510.64
47_A50_I0.5490.63
147_E151_A0.5480.63
24_W27_G0.5470.63
112_L149_L0.5460.63
201_A266_L0.5450.63
238_S246_E0.5450.63
264_R275_R0.5450.63
114_D220_D0.5450.63
93_H96_R0.5450.63
246_E254_E0.5440.63
256_R263_N0.5430.63
62_M65_P0.5420.62
80_A256_R0.5420.62
23_P26_L0.5410.62
137_A141_Q0.5410.62
12_A58_M0.5410.62
238_S243_A0.5400.62
79_L82_G0.5380.62
47_A186_E0.5340.61
115_Y187_R0.5310.61
209_F222_L0.5310.61
275_R279_T0.5280.60
264_R272_A0.5280.60
197_L234_P0.5250.60
204_H225_L0.5240.60
261_P278_R0.5230.60
259_D269_A0.5220.60
189_L229_I0.5200.59
177_L181_A0.5180.59
185_F192_H0.5140.58
131_L196_E0.5130.58
89_S228_A0.5130.58
170_R173_R0.5120.58
20_F26_L0.5110.58
15_L36_L0.5110.58
89_S154_E0.5090.58
142_Q178_F0.5080.58
50_I93_H0.5080.58
266_L279_T0.5080.58
275_R278_R0.5070.57
83_L200_E0.5050.57
84_W115_Y0.5050.57
183_D191_S0.5040.57
182_V186_E0.5020.57
46_R99_R0.5020.57
157_L183_D0.5000.56
20_F33_L0.5000.56
73_L77_L0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wdoA 1 0.5704 57.9 0.926 Contact Map
4ikvA 1 0.3592 31.7 0.937 Contact Map
4xnjA 1 0.3415 28.7 0.938 Contact Map
4ltoA 3 0.4613 28.4 0.939 Contact Map
4tphA 2 0.3345 28 0.939 Contact Map
2cfqA 1 0.3944 27.6 0.939 Contact Map
4jkvA 2 0.3556 26.7 0.939 Contact Map
4m64A 1 0.3944 23.4 0.941 Contact Map
4w6vA 1 0.3627 23 0.941 Contact Map
4cbcA 3 0.3099 17.9 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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