GREMLIN Database
RsgI_N - Anti-sigma factor N-terminus
PFAM: PF12791 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (50)
Sequences: 859 (780)
Seq/√Len: 110.3
META: 0.725

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_Y19_K3.6131.00
8_A22_R2.9191.00
11_L17_F2.6021.00
8_A26_M2.5581.00
11_L15_G2.1491.00
18_L34_F2.1201.00
3_I8_A1.6191.00
22_R26_M1.5421.00
13_P31_E1.4971.00
12_T34_F1.4101.00
9_I17_F1.3901.00
4_K9_I1.3731.00
26_M30_Q1.3501.00
12_T16_E1.3221.00
27_E30_Q1.3030.99
1_M17_F1.2360.99
17_F30_Q1.2110.99
10_V34_F1.1840.99
32_I35_P1.1180.98
8_A20_I1.0790.98
34_F40_I1.0660.98
1_M11_L1.0500.97
4_K19_K1.0440.97
1_M15_G1.0260.97
19_K23_K1.0210.97
2_E9_I1.0190.97
10_V20_I0.9990.97
27_E31_E0.9430.95
44_R47_L0.9150.94
39_I43_K0.8940.94
38_D41_K0.8720.93
19_K48_Y0.8370.91
2_E17_F0.8200.90
14_D49_A0.8120.90
10_V35_P0.8080.90
30_Q35_P0.8060.90
32_I49_A0.7860.88
39_I46_L0.7820.88
8_A11_L0.7820.88
3_I32_I0.7690.87
47_L50_A0.7660.87
15_G31_E0.7590.87
23_K38_D0.7500.86
36_E40_I0.7480.86
34_F38_D0.7470.86
37_K42_K0.7390.85
6_K41_K0.7350.85
46_L50_A0.7340.85
9_I13_P0.7290.84
5_K39_I0.7190.84
15_G29_G0.6870.81
33_E39_I0.6690.79
20_I29_G0.6580.78
11_L28_V0.6580.78
7_Y10_V0.6340.75
23_K26_M0.6190.74
14_D34_F0.6180.73
2_E11_L0.6170.73
42_K45_K0.6160.73
24_K27_E0.6150.73
39_I44_R0.6150.73
17_F27_E0.6080.72
36_E44_R0.6070.72
44_R49_A0.6070.72
19_K31_E0.5890.70
15_G30_Q0.5740.68
26_M32_I0.5740.68
18_L33_E0.5740.68
21_K40_I0.5650.67
11_L30_Q0.5600.66
7_Y22_R0.5550.65
13_P37_K0.5500.65
10_V49_A0.5290.62
17_F33_E0.5280.61
7_Y48_Y0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bbjA 1 0.9811 38.1 0.769 Contact Map
4umwA 1 0.9623 21.5 0.796 Contact Map
1vw4N 1 1 20.6 0.798 Contact Map
3j08A 2 0.9623 18.5 0.802 Contact Map
3j09A 2 0.9623 18.4 0.802 Contact Map
1whiA 2 0.8113 15.5 0.808 Contact Map
4rb6O 1 0.8113 15.1 0.809 Contact Map
1t9hA 1 1 14.7 0.811 Contact Map
1khiA 1 0.9057 13.9 0.813 Contact Map
3bboT 1 0.9057 13.4 0.814 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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