GREMLIN Database
EcsC - EcsC protein family
PFAM: PF12787 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 246 (235)
Sequences: 3519 (2558)
Seq/√Len: 166.8
META: 0.716

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_S84_T4.0641.00
101_A227_Y3.7211.00
105_A223_A3.6671.00
90_R238_R3.5401.00
129_S234_Q3.1931.00
81_S85_L3.1631.00
97_K231_D3.1511.00
110_G114_A3.0151.00
239_G242_R2.9371.00
31_K34_K2.8741.00
209_K212_Q2.6361.00
94_R98_K2.6261.00
93_I234_Q2.4461.00
139_E244_R2.3981.00
50_K54_A2.3721.00
140_D143_D2.3151.00
208_K212_Q2.2251.00
5_K8_R2.2171.00
49_K53_R2.2161.00
216_V220_A2.2021.00
118_D226_N2.1231.00
169_K173_E2.1131.00
137_Y238_R2.0881.00
82_L86_D2.0841.00
89_A133_I2.0551.00
153_V240_H2.0491.00
31_K35_L2.0341.00
50_K53_R2.0301.00
173_E176_E2.0291.00
139_E245_R2.0231.00
129_S133_I1.9851.00
126_M230_I1.9721.00
113_L116_L1.9681.00
59_A62_T1.9421.00
32_I35_L1.8971.00
43_A46_K1.8931.00
130_I237_A1.8581.00
86_D89_A1.8461.00
89_A136_S1.8161.00
146_E244_R1.8141.00
100_A230_I1.7261.00
149_F152_E1.6551.00
214_V217_I1.6141.00
5_K9_R1.5711.00
86_D137_Y1.5311.00
143_D146_E1.5211.00
4_L8_R1.5061.00
121_L124_T1.5011.00
129_S230_I1.4991.00
224_A227_Y1.4731.00
11_K243_V1.4681.00
202_G206_D1.4611.00
164_R168_A1.4331.00
40_V43_A1.4301.00
146_E241_Y1.4231.00
13_K235_E1.4131.00
163_V166_A1.3841.00
166_A170_A1.3771.00
43_A47_A1.3731.00
22_N25_S1.3721.00
100_A103_E1.3641.00
92_S136_S1.3631.00
89_A137_Y1.3451.00
54_A57_D1.3411.00
84_T88_L1.3411.00
117_A120_P1.3101.00
139_E146_E1.3041.00
220_A224_A1.2981.00
65_K68_V1.2851.00
9_R12_K1.2781.00
25_S28_P1.2691.00
137_Y242_R1.2681.00
52_L55_A1.2511.00
48_I52_L1.2431.00
8_R12_K1.2311.00
59_A63_T1.2181.00
218_G222_G1.2111.00
176_E179_A1.2101.00
80_L84_T1.2021.00
165_A169_K1.1971.00
224_A228_A1.1931.00
86_D242_R1.1801.00
93_I129_S1.1791.00
133_I136_S1.1751.00
134_A141_L1.1711.00
38_E42_E1.1671.00
183_D186_G1.1601.00
102_A105_A1.1601.00
107_T121_L1.1491.00
95_L99_L1.1491.00
127_L131_A1.1481.00
220_A223_A1.1351.00
192_R195_R1.1261.00
82_L85_L1.1151.00
6_E9_R1.0951.00
52_L56_L1.0931.00
26_G30_E1.0801.00
175_A178_L1.0771.00
104_G108_G1.0580.99
83_E87_R1.0540.99
8_R11_K1.0480.99
166_A169_K1.0440.99
111_G120_P1.0440.99
130_I153_V1.0440.99
238_R242_R1.0380.99
168_A172_S1.0380.99
128_R132_D1.0340.99
92_S95_L1.0300.99
125_I230_I1.0230.99
80_L85_L1.0160.99
28_P32_I1.0160.99
57_D147_R1.0140.99
10_W14_L1.0130.99
11_K168_A1.0120.99
23_R30_E1.0120.99
51_A55_A0.9940.99
78_A81_S0.9780.99
163_V167_L0.9770.99
99_L103_E0.9740.99
173_E177_Y0.9730.99
169_K172_S0.9720.99
208_K232_H0.9690.99
141_L146_E0.9680.99
38_E195_R0.9610.99
239_G243_V0.9560.99
46_K49_K0.9550.99
152_E170_A0.9500.99
15_E169_K0.9460.99
130_I150_C0.9390.99
139_E149_F0.9370.99
11_K172_S0.9350.99
61_Y65_K0.9340.99
39_K43_A0.9290.99
7_L10_W0.9250.99
32_I40_V0.9190.98
203_D206_D0.9140.98
27_K31_K0.9140.98
196_Q199_Q0.9140.98
137_Y245_R0.9090.98
19_A22_N0.9070.98
96_H99_L0.9060.98
83_E86_D0.9030.98
27_K30_E0.9030.98
164_R174_A0.9020.98
46_K50_K0.8860.98
122_L229_F0.8810.98
111_G128_R0.8750.98
135_R141_L0.8740.98
62_T65_K0.8720.98
205_V210_A0.8690.98
152_E155_A0.8680.98
12_K16_K0.8680.98
64_K67_A0.8680.98
103_E107_T0.8660.98
132_D135_R0.8650.98
109_A219_A0.8640.98
21_L30_E0.8610.98
122_L230_I0.8580.98
26_G29_Q0.8570.98
195_R199_Q0.8510.97
225_V228_A0.8470.97
92_S132_D0.8440.97
171_L193_L0.8410.97
97_K127_L0.8370.97
102_A106_V0.8280.97
98_K101_A0.8260.97
212_Q222_G0.8260.97
11_K15_E0.8220.97
17_L21_L0.8210.97
106_V114_A0.8140.97
25_S29_Q0.8100.97
189_W192_R0.8030.96
6_E13_K0.8030.96
93_I238_R0.7970.96
42_E46_K0.7970.96
55_A60_K0.7960.96
149_F154_F0.7920.96
99_L102_A0.7900.96
105_A211_A0.7860.96
45_T56_L0.7860.96
60_K67_A0.7850.96
67_A80_L0.7790.96
7_L243_V0.7740.96
198_A202_G0.7610.95
9_R13_K0.7590.95
158_G206_D0.7570.95
44_I59_A0.7550.95
146_E151_L0.7550.95
63_T67_A0.7490.95
96_H132_D0.7470.95
10_W15_E0.7470.95
15_E172_S0.7440.95
188_P191_V0.7400.94
199_Q204_Y0.7380.94
25_S30_E0.7360.94
16_K20_R0.7330.94
232_H236_T0.7330.94
5_K12_K0.7290.94
27_K35_L0.7190.94
96_H128_R0.7180.93
154_F233_F0.7160.93
60_K63_T0.7150.93
146_E149_F0.7120.93
119_L205_V0.7090.93
99_L125_I0.7050.93
48_I58_G0.7050.93
94_R142_K0.7050.93
20_R28_P0.7030.93
217_I220_A0.6990.93
20_R25_S0.6930.92
14_L20_R0.6900.92
85_L88_L0.6900.92
7_L15_E0.6900.92
116_L212_Q0.6880.92
126_M233_F0.6870.92
132_D136_S0.6850.92
172_S175_A0.6850.92
227_Y231_D0.6850.92
54_A58_G0.6840.92
225_V229_F0.6810.92
122_L157_A0.6770.91
22_N35_L0.6760.91
131_A141_L0.6620.90
81_S86_D0.6620.90
6_E10_W0.6580.90
139_E212_Q0.6570.90
19_A25_S0.6560.90
62_T66_P0.6550.90
24_L27_K0.6540.90
13_K17_L0.6480.89
161_D165_A0.6470.89
47_A58_G0.6470.89
158_G236_T0.6460.89
198_A201_F0.6430.89
243_V246_L0.6400.89
93_I97_K0.6390.89
18_A22_N0.6320.88
203_D226_N0.6320.88
103_E125_I0.6280.88
4_L14_L0.6280.88
241_Y245_R0.6240.88
7_L14_L0.6210.87
147_R151_L0.6180.87
104_G226_N0.6170.87
100_A125_I0.6160.87
144_P147_R0.6150.87
97_K227_Y0.6140.87
108_G111_G0.6130.87
199_Q202_G0.6130.87
124_T212_Q0.6120.87
28_P33_N0.6120.87
121_L125_I0.6120.87
95_L125_I0.6090.86
85_L89_A0.6080.86
85_L245_R0.6070.86
29_Q32_I0.6070.86
241_Y244_R0.6060.86
91_S94_R0.6060.86
229_F232_H0.6050.86
16_K19_A0.6000.86
112_L115_L0.5990.85
95_L132_D0.5980.85
193_L197_I0.5950.85
46_K91_S0.5950.85
171_L174_A0.5950.85
52_L59_A0.5930.85
12_K15_E0.5930.85
23_R27_K0.5920.85
161_D172_S0.5910.85
29_Q33_N0.5910.85
115_L120_P0.5880.84
155_A219_A0.5880.84
185_E189_W0.5870.84
103_E121_L0.5860.84
119_L201_F0.5860.84
80_L83_E0.5850.84
184_I187_A0.5830.84
79_D84_T0.5830.84
174_A177_Y0.5820.84
47_A55_A0.5820.84
66_P69_K0.5820.84
91_S95_L0.5810.84
212_Q218_G0.5790.83
37_P48_I0.5780.83
56_L131_A0.5770.83
111_G212_Q0.5770.83
59_A65_K0.5760.83
122_L170_A0.5750.83
127_L157_A0.5740.83
43_A50_K0.5740.83
93_I133_I0.5730.83
201_F213_A0.5730.83
140_D245_R0.5730.83
227_Y230_I0.5720.83
149_F240_H0.5710.83
20_R30_E0.5710.83
229_F233_F0.5680.82
93_I147_R0.5670.82
169_K176_E0.5600.81
18_A27_K0.5590.81
203_D207_E0.5570.81
48_I51_A0.5560.81
126_M229_F0.5540.81
63_T66_P0.5520.81
120_P218_G0.5510.80
150_C241_Y0.5510.80
194_I202_G0.5480.80
45_T49_K0.5480.80
146_E209_K0.5470.80
189_W193_L0.5460.80
209_K241_Y0.5460.80
44_I48_I0.5440.80
12_K42_E0.5420.79
60_K65_K0.5410.79
8_R17_L0.5400.79
118_D242_R0.5360.79
62_T68_V0.5350.78
142_K162_E0.5340.78
157_A236_T0.5300.78
236_T239_G0.5290.78
161_D164_R0.5260.77
37_P47_A0.5250.77
231_D235_E0.5240.77
21_L25_S0.5230.77
38_E41_H0.5230.77
93_I101_A0.5210.77
149_F153_V0.5200.76
29_Q36_L0.5180.76
67_A121_L0.5170.76
153_V232_H0.5160.76
22_N26_G0.5160.76
83_E88_L0.5150.76
102_A113_L0.5150.76
153_V237_A0.5140.76
208_K225_V0.5130.76
154_F202_G0.5120.75
111_G222_G0.5120.75
110_G125_I0.5100.75
60_K125_I0.5100.75
20_R26_G0.5080.75
22_N29_Q0.5080.75
173_E192_R0.5070.75
17_L26_G0.5070.75
178_L182_L0.5060.75
197_I205_V0.5060.75
19_A26_G0.5040.74
90_R93_I0.5040.74
226_N229_F0.5030.74
40_V45_T0.5030.74
88_L216_V0.5010.74
219_A225_V0.5010.74
13_K16_K0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mhsB 1 0.2317 8.6 0.951 Contact Map
3jsbA 2 0.3089 7.5 0.952 Contact Map
4i1tA 2 0.2114 6.5 0.954 Contact Map
4dhxB 1 0.2276 6.2 0.954 Contact Map
3hlsA 4 0.187 5.4 0.955 Contact Map
2o1xA 2 0.6545 4.2 0.958 Contact Map
2kmfA 1 0.2398 4.1 0.958 Contact Map
3c4rA 4 0.248 3.6 0.959 Contact Map
4lv5B 1 0.7927 3.5 0.959 Contact Map
2nynA 4 0.561 3.3 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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