EcsC - PFAM28P - GREMLIN Contacts

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EcsC - EcsC protein family

PFAM:	PF12787	Sequences: QKALKELRRWKKKLEKLAARLNRLSGKPQEKINKLLPEKVHEAITKAIKKALRAALDGAKYTTKKPAVKDIESLEDLADLSLETLDRLARSSIRLHKKLAAAEGAVTGAGGLLALLADLPLLTTIMLRSIADIARSYGEDLKDPEERLFCLEVFALAGSSDEVRAALAKALSEAAEYLAKGLDIEGAPWLVRLIRQIAQRFGDYVDEKKAAQAVPVIGAAVGAAVNYAFIDHFQETARGHYRVRRL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	246 (235)
Sequences:	3519 (2558)
Seq/√Len:	166.8
META:	0.716

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
81_S	84_T	4.064	1.00
101_A	227_Y	3.721	1.00
105_A	223_A	3.667	1.00
90_R	238_R	3.540	1.00
129_S	234_Q	3.193	1.00
81_S	85_L	3.163	1.00
97_K	231_D	3.151	1.00
110_G	114_A	3.015	1.00
239_G	242_R	2.937	1.00
31_K	34_K	2.874	1.00
209_K	212_Q	2.636	1.00
94_R	98_K	2.626	1.00
93_I	234_Q	2.446	1.00
139_E	244_R	2.398	1.00
50_K	54_A	2.372	1.00
140_D	143_D	2.315	1.00
208_K	212_Q	2.225	1.00
5_K	8_R	2.217	1.00
49_K	53_R	2.216	1.00
216_V	220_A	2.202	1.00
118_D	226_N	2.123	1.00
169_K	173_E	2.113	1.00
137_Y	238_R	2.088	1.00
82_L	86_D	2.084	1.00
89_A	133_I	2.055	1.00
153_V	240_H	2.049	1.00
31_K	35_L	2.034	1.00
50_K	53_R	2.030	1.00
173_E	176_E	2.029	1.00
139_E	245_R	2.023	1.00
129_S	133_I	1.985	1.00
126_M	230_I	1.972	1.00
113_L	116_L	1.968	1.00
59_A	62_T	1.942	1.00
32_I	35_L	1.897	1.00
43_A	46_K	1.893	1.00
130_I	237_A	1.858	1.00
86_D	89_A	1.846	1.00
89_A	136_S	1.816	1.00
146_E	244_R	1.814	1.00
100_A	230_I	1.726	1.00
149_F	152_E	1.655	1.00
214_V	217_I	1.614	1.00
5_K	9_R	1.571	1.00
86_D	137_Y	1.531	1.00
143_D	146_E	1.521	1.00
4_L	8_R	1.506	1.00
121_L	124_T	1.501	1.00
129_S	230_I	1.499	1.00
224_A	227_Y	1.473	1.00
11_K	243_V	1.468	1.00
202_G	206_D	1.461	1.00
164_R	168_A	1.433	1.00
40_V	43_A	1.430	1.00
146_E	241_Y	1.423	1.00
13_K	235_E	1.413	1.00
163_V	166_A	1.384	1.00
166_A	170_A	1.377	1.00
43_A	47_A	1.373	1.00
22_N	25_S	1.372	1.00
100_A	103_E	1.364	1.00
92_S	136_S	1.363	1.00
89_A	137_Y	1.345	1.00
54_A	57_D	1.341	1.00
84_T	88_L	1.341	1.00
117_A	120_P	1.310	1.00
139_E	146_E	1.304	1.00
220_A	224_A	1.298	1.00
65_K	68_V	1.285	1.00
9_R	12_K	1.278	1.00
25_S	28_P	1.269	1.00
137_Y	242_R	1.268	1.00
52_L	55_A	1.251	1.00
48_I	52_L	1.243	1.00
8_R	12_K	1.231	1.00
59_A	63_T	1.218	1.00
218_G	222_G	1.211	1.00
176_E	179_A	1.210	1.00
80_L	84_T	1.202	1.00
165_A	169_K	1.197	1.00
224_A	228_A	1.193	1.00
86_D	242_R	1.180	1.00
93_I	129_S	1.179	1.00
133_I	136_S	1.175	1.00
134_A	141_L	1.171	1.00
38_E	42_E	1.167	1.00
183_D	186_G	1.160	1.00
102_A	105_A	1.160	1.00
107_T	121_L	1.149	1.00
95_L	99_L	1.149	1.00
127_L	131_A	1.148	1.00
220_A	223_A	1.135	1.00
192_R	195_R	1.126	1.00
82_L	85_L	1.115	1.00
6_E	9_R	1.095	1.00
52_L	56_L	1.093	1.00
26_G	30_E	1.080	1.00
175_A	178_L	1.077	1.00
104_G	108_G	1.058	0.99
83_E	87_R	1.054	0.99
8_R	11_K	1.048	0.99
166_A	169_K	1.044	0.99
111_G	120_P	1.044	0.99
130_I	153_V	1.044	0.99
238_R	242_R	1.038	0.99
168_A	172_S	1.038	0.99
128_R	132_D	1.034	0.99
92_S	95_L	1.030	0.99
125_I	230_I	1.023	0.99
80_L	85_L	1.016	0.99
28_P	32_I	1.016	0.99
57_D	147_R	1.014	0.99
10_W	14_L	1.013	0.99
11_K	168_A	1.012	0.99
23_R	30_E	1.012	0.99
51_A	55_A	0.994	0.99
78_A	81_S	0.978	0.99
163_V	167_L	0.977	0.99
99_L	103_E	0.974	0.99
173_E	177_Y	0.973	0.99
169_K	172_S	0.972	0.99
208_K	232_H	0.969	0.99
141_L	146_E	0.968	0.99
38_E	195_R	0.961	0.99
239_G	243_V	0.956	0.99
46_K	49_K	0.955	0.99
152_E	170_A	0.950	0.99
15_E	169_K	0.946	0.99
130_I	150_C	0.939	0.99
139_E	149_F	0.937	0.99
11_K	172_S	0.935	0.99
61_Y	65_K	0.934	0.99
39_K	43_A	0.929	0.99
7_L	10_W	0.925	0.99
32_I	40_V	0.919	0.98
203_D	206_D	0.914	0.98
27_K	31_K	0.914	0.98
196_Q	199_Q	0.914	0.98
137_Y	245_R	0.909	0.98
19_A	22_N	0.907	0.98
96_H	99_L	0.906	0.98
83_E	86_D	0.903	0.98
27_K	30_E	0.903	0.98
164_R	174_A	0.902	0.98
46_K	50_K	0.886	0.98
122_L	229_F	0.881	0.98
111_G	128_R	0.875	0.98
135_R	141_L	0.874	0.98
62_T	65_K	0.872	0.98
205_V	210_A	0.869	0.98
152_E	155_A	0.868	0.98
12_K	16_K	0.868	0.98
64_K	67_A	0.868	0.98
103_E	107_T	0.866	0.98
132_D	135_R	0.865	0.98
109_A	219_A	0.864	0.98
21_L	30_E	0.861	0.98
122_L	230_I	0.858	0.98
26_G	29_Q	0.857	0.98
195_R	199_Q	0.851	0.97
225_V	228_A	0.847	0.97
92_S	132_D	0.844	0.97
171_L	193_L	0.841	0.97
97_K	127_L	0.837	0.97
102_A	106_V	0.828	0.97
98_K	101_A	0.826	0.97
212_Q	222_G	0.826	0.97
11_K	15_E	0.822	0.97
17_L	21_L	0.821	0.97
106_V	114_A	0.814	0.97
25_S	29_Q	0.810	0.97
189_W	192_R	0.803	0.96
6_E	13_K	0.803	0.96
93_I	238_R	0.797	0.96
42_E	46_K	0.797	0.96
55_A	60_K	0.796	0.96
149_F	154_F	0.792	0.96
99_L	102_A	0.790	0.96
105_A	211_A	0.786	0.96
45_T	56_L	0.786	0.96
60_K	67_A	0.785	0.96
67_A	80_L	0.779	0.96
7_L	243_V	0.774	0.96
198_A	202_G	0.761	0.95
9_R	13_K	0.759	0.95
158_G	206_D	0.757	0.95
44_I	59_A	0.755	0.95
146_E	151_L	0.755	0.95
63_T	67_A	0.749	0.95
96_H	132_D	0.747	0.95
10_W	15_E	0.747	0.95
15_E	172_S	0.744	0.95
188_P	191_V	0.740	0.94
199_Q	204_Y	0.738	0.94
25_S	30_E	0.736	0.94
16_K	20_R	0.733	0.94
232_H	236_T	0.733	0.94
5_K	12_K	0.729	0.94
27_K	35_L	0.719	0.94
96_H	128_R	0.718	0.93
154_F	233_F	0.716	0.93
60_K	63_T	0.715	0.93
146_E	149_F	0.712	0.93
119_L	205_V	0.709	0.93
99_L	125_I	0.705	0.93
48_I	58_G	0.705	0.93
94_R	142_K	0.705	0.93
20_R	28_P	0.703	0.93
217_I	220_A	0.699	0.93
20_R	25_S	0.693	0.92
14_L	20_R	0.690	0.92
85_L	88_L	0.690	0.92
7_L	15_E	0.690	0.92
116_L	212_Q	0.688	0.92
126_M	233_F	0.687	0.92
132_D	136_S	0.685	0.92
172_S	175_A	0.685	0.92
227_Y	231_D	0.685	0.92
54_A	58_G	0.684	0.92
225_V	229_F	0.681	0.92
122_L	157_A	0.677	0.91
22_N	35_L	0.676	0.91
131_A	141_L	0.662	0.90
81_S	86_D	0.662	0.90
6_E	10_W	0.658	0.90
139_E	212_Q	0.657	0.90
19_A	25_S	0.656	0.90
62_T	66_P	0.655	0.90
24_L	27_K	0.654	0.90
13_K	17_L	0.648	0.89
161_D	165_A	0.647	0.89
47_A	58_G	0.647	0.89
158_G	236_T	0.646	0.89
198_A	201_F	0.643	0.89
243_V	246_L	0.640	0.89
93_I	97_K	0.639	0.89
18_A	22_N	0.632	0.88
203_D	226_N	0.632	0.88
103_E	125_I	0.628	0.88
4_L	14_L	0.628	0.88
241_Y	245_R	0.624	0.88
7_L	14_L	0.621	0.87
147_R	151_L	0.618	0.87
104_G	226_N	0.617	0.87
100_A	125_I	0.616	0.87
144_P	147_R	0.615	0.87
97_K	227_Y	0.614	0.87
108_G	111_G	0.613	0.87
199_Q	202_G	0.613	0.87
124_T	212_Q	0.612	0.87
28_P	33_N	0.612	0.87
121_L	125_I	0.612	0.87
95_L	125_I	0.609	0.86
85_L	89_A	0.608	0.86
85_L	245_R	0.607	0.86
29_Q	32_I	0.607	0.86
241_Y	244_R	0.606	0.86
91_S	94_R	0.606	0.86
229_F	232_H	0.605	0.86
16_K	19_A	0.600	0.86
112_L	115_L	0.599	0.85
95_L	132_D	0.598	0.85
193_L	197_I	0.595	0.85
46_K	91_S	0.595	0.85
171_L	174_A	0.595	0.85
52_L	59_A	0.593	0.85
12_K	15_E	0.593	0.85
23_R	27_K	0.592	0.85
161_D	172_S	0.591	0.85
29_Q	33_N	0.591	0.85
115_L	120_P	0.588	0.84
155_A	219_A	0.588	0.84
185_E	189_W	0.587	0.84
103_E	121_L	0.586	0.84
119_L	201_F	0.586	0.84
80_L	83_E	0.585	0.84
184_I	187_A	0.583	0.84
79_D	84_T	0.583	0.84
174_A	177_Y	0.582	0.84
47_A	55_A	0.582	0.84
66_P	69_K	0.582	0.84
91_S	95_L	0.581	0.84
212_Q	218_G	0.579	0.83
37_P	48_I	0.578	0.83
56_L	131_A	0.577	0.83
111_G	212_Q	0.577	0.83
59_A	65_K	0.576	0.83
122_L	170_A	0.575	0.83
127_L	157_A	0.574	0.83
43_A	50_K	0.574	0.83
93_I	133_I	0.573	0.83
201_F	213_A	0.573	0.83
140_D	245_R	0.573	0.83
227_Y	230_I	0.572	0.83
149_F	240_H	0.571	0.83
20_R	30_E	0.571	0.83
229_F	233_F	0.568	0.82
93_I	147_R	0.567	0.82
169_K	176_E	0.560	0.81
18_A	27_K	0.559	0.81
203_D	207_E	0.557	0.81
48_I	51_A	0.556	0.81
126_M	229_F	0.554	0.81
63_T	66_P	0.552	0.81
120_P	218_G	0.551	0.80
150_C	241_Y	0.551	0.80
194_I	202_G	0.548	0.80
45_T	49_K	0.548	0.80
146_E	209_K	0.547	0.80
189_W	193_L	0.546	0.80
209_K	241_Y	0.546	0.80
44_I	48_I	0.544	0.80
12_K	42_E	0.542	0.79
60_K	65_K	0.541	0.79
8_R	17_L	0.540	0.79
118_D	242_R	0.536	0.79
62_T	68_V	0.535	0.78
142_K	162_E	0.534	0.78
157_A	236_T	0.530	0.78
236_T	239_G	0.529	0.78
161_D	164_R	0.526	0.77
37_P	47_A	0.525	0.77
231_D	235_E	0.524	0.77
21_L	25_S	0.523	0.77
38_E	41_H	0.523	0.77
93_I	101_A	0.521	0.77
149_F	153_V	0.520	0.76
29_Q	36_L	0.518	0.76
67_A	121_L	0.517	0.76
153_V	232_H	0.516	0.76
22_N	26_G	0.516	0.76
83_E	88_L	0.515	0.76
102_A	113_L	0.515	0.76
153_V	237_A	0.514	0.76
208_K	225_V	0.513	0.76
154_F	202_G	0.512	0.75
111_G	222_G	0.512	0.75
110_G	125_I	0.510	0.75
60_K	125_I	0.510	0.75
20_R	26_G	0.508	0.75
22_N	29_Q	0.508	0.75
173_E	192_R	0.507	0.75
17_L	26_G	0.507	0.75
178_L	182_L	0.506	0.75
197_I	205_V	0.506	0.75
19_A	26_G	0.504	0.74
90_R	93_I	0.504	0.74
226_N	229_F	0.503	0.74
40_V	45_T	0.503	0.74
88_L	216_V	0.501	0.74
219_A	225_V	0.501	0.74
13_K	16_K	0.500	0.74

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3mhsB	1	0.2317	8.6	0.951	Contact Map
3jsbA	2	0.3089	7.5	0.952	Contact Map
4i1tA	2	0.2114	6.5	0.954	Contact Map
4dhxB	1	0.2276	6.2	0.954	Contact Map
3hlsA	4	0.187	5.4	0.955	Contact Map
2o1xA	2	0.6545	4.2	0.958	Contact Map
2kmfA	1	0.2398	4.1	0.958	Contact Map
3c4rA	4	0.248	3.6	0.959	Contact Map
4lv5B	1	0.7927	3.5	0.959	Contact Map
2nynA	4	0.561	3.3	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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