GREMLIN Database
SUZ - SUZ domain
PFAM: PF12752 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (54)
Sequences: 887 (674)
Seq/√Len: 91.7
META: 0.337

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_A50_E3.4101.00
39_K47_E3.3781.00
49_A53_A2.3021.00
45_E49_A2.2911.00
53_A56_F2.0681.00
43_E47_E1.9691.00
40_S44_R1.8041.00
47_E50_E1.7161.00
53_A58_S1.6711.00
2_Q5_V1.5691.00
47_E51_A1.5201.00
29_S32_K1.4901.00
5_V9_K1.4761.00
3_P8_L1.4370.99
32_K35_S1.3720.99
9_K12_S1.2800.99
40_S43_E1.2780.99
8_L47_E1.2780.99
41_L45_E1.1830.98
6_K9_K1.1800.98
49_A56_F1.1520.97
12_S45_E1.1330.97
21_S25_S1.0530.96
14_A19_S1.0440.95
8_L11_P1.0350.95
4_K46_A1.0190.95
28_G34_K0.9760.93
24_T27_A0.9660.93
49_A59_S0.9350.92
14_A17_S0.9340.92
31_G34_K0.9270.92
50_E57_G0.9060.91
25_S28_G0.9030.90
53_A57_G0.8980.90
35_S38_S0.8890.90
18_S21_S0.8670.89
15_S19_S0.8570.88
30_S33_K0.8540.88
6_K41_L0.8260.86
43_E46_A0.8200.86
41_L47_E0.8120.85
26_E30_S0.8110.85
15_S18_S0.8110.85
29_S33_K0.8010.84
38_S42_E0.7930.84
42_E50_E0.7810.83
38_S54_R0.7740.82
18_S30_S0.7720.82
14_A20_P0.7650.82
16_S24_T0.7420.80
51_A54_R0.7330.79
5_V46_A0.7160.77
11_P57_G0.6960.75
35_S58_S0.6790.73
29_S34_K0.6720.72
17_S27_A0.6510.70
37_P54_R0.6480.70
21_S27_A0.6380.69
16_S19_S0.6270.67
9_K39_K0.6110.65
7_I12_S0.6090.65
20_P33_K0.6090.65
15_S35_S0.6080.65
16_S20_P0.6060.65
50_E53_A0.6010.64
12_S19_S0.5930.63
26_E31_G0.5920.63
5_V42_E0.5900.63
14_A18_S0.5870.62
31_G54_R0.5770.61
7_I11_P0.5750.61
41_L46_A0.5640.59
3_P6_K0.5630.59
8_L43_E0.5430.56
46_A55_I0.5340.55
18_S31_G0.5260.54
7_I41_L0.5140.52
53_A59_S0.5030.51
5_V38_S0.5020.51
42_E49_A0.5000.50
20_P25_S0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5aj3i 1 0.3333 9 0.835 Contact Map
4my6A 1 0.3167 2.1 0.879 Contact Map
3syyA 3 0.2667 1.9 0.882 Contact Map
2iaiA 2 0.4 1.4 0.891 Contact Map
3axjA 1 0.6 1.3 0.892 Contact Map
2zjrL 1 0.25 1.1 0.897 Contact Map
2hs5A 1 0.3333 1 0.9 Contact Map
3h8kB 1 0.45 1 0.9 Contact Map
1g8lA 2 0.2667 0.9 0.903 Contact Map
3wamA 2 0.4667 0.9 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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