GREMLIN Database
Maff2 - Maff2 family
PFAM: PF12750 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 70 (70)
Sequences: 508 (190)
Seq/√Len: 22.7
META: 0.872

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_N40_G3.4181.00
65_L68_G2.4430.98
44_Q48_Q2.2780.97
2_E5_T2.1610.96
34_Y37_D2.1180.95
49_L53_G2.0410.94
59_G63_V1.9650.93
24_V63_V1.9460.92
23_G65_L1.8730.91
17_A53_G1.8510.90
1_M4_F1.8410.90
37_D44_Q1.7680.88
16_I60_T1.7550.88
16_I59_G1.7300.87
6_S9_D1.7060.86
21_G50_M1.6680.85
4_F13_T1.5710.81
30_L39_P1.5670.81
33_G45_G1.4710.77
10_V18_L1.4540.76
2_E9_D1.4140.74
40_G43_S1.4040.73
31_L58_I1.4020.73
67_S70_F1.3700.71
42_K47_K1.3140.68
7_A17_A1.2480.64
43_S54_G1.2400.63
17_A21_G1.2390.63
33_G36_N1.1810.59
34_Y47_K1.1480.57
45_G48_Q1.0830.53
6_S12_Q1.0720.52
16_I69_L1.0720.52
55_V61_T1.0680.52
15_V46_I1.0400.50
14_L17_A1.0170.48
8_I13_T1.0150.48
6_S13_T1.0060.47
29_N48_Q0.9880.46
39_P42_K0.9790.46
27_V56_A0.8960.40
37_D47_K0.8890.40
62_L67_S0.8660.38
33_G38_N0.8590.38
16_I56_A0.8510.37
10_V62_L0.8500.37
29_N38_N0.8470.37
32_E36_N0.8430.37
18_L21_G0.8390.36
44_Q47_K0.8280.36
17_A55_V0.8280.36
44_Q51_A0.8250.35
27_V53_G0.8190.35
56_A59_G0.7970.34
44_Q66_L0.7950.34
60_T63_V0.7510.31
34_Y43_S0.7450.31
22_L57_L0.7360.30
47_K54_G0.7290.30
37_D66_L0.7180.29
15_V28_I0.7150.29
61_T65_L0.7070.28
42_K51_A0.6960.28
5_T68_G0.6940.28
33_G66_L0.6920.28
24_V61_T0.6890.27
24_V56_A0.6820.27
34_Y38_N0.6720.26
51_A56_A0.6680.26
24_V60_T0.6660.26
2_E16_I0.6630.26
12_Q59_G0.6580.26
33_G52_G0.6500.25
34_Y54_G0.6360.25
31_L60_T0.6290.24
4_F55_V0.6260.24
27_V50_M0.6190.24
24_V49_L0.6130.23
25_W35_G0.6110.23
29_N34_Y0.6100.23
2_E23_G0.6030.23
27_V70_F0.6000.23
36_N44_Q0.5920.22
15_V59_G0.5780.22
57_L61_T0.5710.21
17_A50_M0.5700.21
9_D13_T0.5630.21
30_L35_G0.5580.21
4_F12_Q0.5560.21
6_S10_V0.5520.20
22_L25_W0.5510.20
30_L41_A0.5510.20
9_D67_S0.5410.20
30_L47_K0.5340.20
43_S49_L0.5320.20
15_V49_L0.5260.19
37_D48_Q0.5210.19
12_Q60_T0.5170.19
35_G48_Q0.5160.19
57_L60_T0.5110.19
47_K51_A0.5100.19
61_T69_L0.5070.19
7_A49_L0.5040.18
31_L54_G0.5020.18
50_M54_G0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bs2C 2 0.6571 4.6 0.911 Contact Map
4humA 1 0.9857 4.5 0.911 Contact Map
3j8eG 3 0.7429 3.6 0.915 Contact Map
4k0jA 3 0.9714 3 0.918 Contact Map
3mktA 1 0.9857 3 0.918 Contact Map
4mt1A 3 0.9714 2.8 0.92 Contact Map
1ckkB 1 0.1571 2.4 0.922 Contact Map
1iq5B 1 0.1143 2.4 0.923 Contact Map
3w4tA 1 0.9857 2.3 0.924 Contact Map
3ne5A 3 0.9714 2.1 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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