GREMLIN Database
Cadherin-like - Cadherin-like beta sandwich domain
PFAM: PF12733 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 90 (85)
Sequences: 27347 (24251)
Seq/√Len: 2630.3
META: 0.933

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_T81_K3.6701.00
69_T82_T2.5261.00
71_V82_T2.3241.00
71_V80_T2.1951.00
65_S86_T2.1661.00
21_T88_T2.1461.00
28_S58_A2.0301.00
19_T86_T2.0101.00
24_N63_V1.9961.00
65_S88_T1.9031.00
39_N75_E1.8921.00
13_P36_A1.7861.00
12_S15_T1.7581.00
17_S86_T1.7511.00
69_T84_T1.7331.00
67_T86_T1.7241.00
43_T71_V1.6721.00
35_A42_V1.6091.00
17_S84_T1.5851.00
74_A78_T1.5741.00
67_T84_T1.5291.00
62_N66_N1.5071.00
6_L20_A1.5041.00
76_D79_T1.4351.00
30_T58_A1.3621.00
43_T48_A1.3531.00
68_I87_V1.2861.00
23_P26_V1.2711.00
73_T80_T1.2551.00
59_I68_I1.2551.00
74_A80_T1.2291.00
37_D40_A1.2081.00
74_A77_G1.2021.00
63_V89_R1.1981.00
44_V48_A1.1951.00
29_I87_V1.1571.00
28_S60_P1.1561.00
49_V52_G1.1511.00
74_A79_T1.1471.00
19_T88_T1.1461.00
20_A87_V1.0971.00
43_T73_T1.0851.00
40_A72_V1.0801.00
5_T32_T1.0401.00
35_A40_A1.0281.00
32_T55_A1.0221.00
44_V47_T1.0111.00
31_V85_I1.0011.00
33_A42_V0.9771.00
22_V26_V0.9601.00
37_D75_E0.9601.00
22_V87_V0.9581.00
31_V68_I0.9551.00
56_S59_I0.8871.00
45_N49_V0.8751.00
7_S30_T0.8461.00
29_I33_A0.8341.00
40_A44_V0.8221.00
13_P83_Y0.8111.00
6_L31_V0.7961.00
45_N69_T0.7961.00
63_V66_N0.7891.00
35_A72_V0.7801.00
4_L7_S0.7781.00
60_P63_V0.7741.00
8_P15_T0.7631.00
47_T50_A0.7581.00
30_T56_S0.7581.00
8_P20_A0.7581.00
47_T57_G0.7571.00
41_T73_T0.7481.00
41_T48_A0.7461.00
20_A31_V0.7381.00
11_F83_Y0.7381.00
46_G49_V0.7361.00
72_V81_K0.7321.00
22_V61_L0.6981.00
3_S34_T0.6901.00
47_T51_S0.6781.00
20_A29_I0.6761.00
43_T49_V0.6731.00
54_S57_G0.6651.00
15_T18_Y0.6641.00
41_T71_V0.6581.00
6_L29_I0.6511.00
44_V68_I0.6501.00
31_V70_I0.6491.00
27_T60_P0.6431.00
33_A44_V0.6421.00
7_S32_T0.6381.00
47_T52_G0.6381.00
36_A40_A0.6361.00
79_T82_T0.6361.00
24_N89_R0.6351.00
70_I85_I0.6341.00
55_A58_A0.6281.00
46_G51_S0.6201.00
4_L85_I0.6151.00
61_L66_N0.6141.00
40_A52_G0.6131.00
33_A70_I0.6101.00
45_N71_V0.6081.00
72_V83_Y0.6051.00
30_T55_A0.5981.00
14_D36_A0.5971.00
20_A88_T0.5961.00
7_S26_V0.5951.00
73_T77_G0.5931.00
11_F15_T0.5851.00
42_V72_V0.5831.00
16_T83_Y0.5791.00
61_L68_I0.5781.00
57_G60_P0.5721.00
19_T65_S0.5691.00
67_T70_I0.5651.00
29_I68_I0.5451.00
33_A45_N0.5441.00
44_V70_I0.5391.00
32_T56_S0.5371.00
30_T33_A0.5371.00
40_A74_A0.5301.00
48_A51_S0.5281.00
3_S6_L0.5261.00
4_L8_P0.5231.00
26_V29_I0.5191.00
73_T79_T0.5081.00
45_N51_S0.5021.00
15_T19_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s30A 1 0.0111 62.2 0.76 Contact Map
4hetA 1 0.9444 59.6 0.764 Contact Map
3hbzA 1 0.8333 51.9 0.774 Contact Map
3owrA 1 0.8778 45.8 0.782 Contact Map
3rrsA 2 0.7333 16.4 0.827 Contact Map
3ncxA 1 0.8667 15 0.83 Contact Map
2l7yA 1 0.8667 13.1 0.834 Contact Map
3fipA 1 0.8667 13 0.834 Contact Map
3zmrA 1 0.7778 9.6 0.844 Contact Map
1nqjA 1 0.9222 9.3 0.845 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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