GREMLIN Database
ABC2_membrane_4 - ABC-2 family transporter protein
PFAM: PF12730 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 230 (217)
Sequences: 121110 (98283)
Seq/√Len: 6671.9
META: 0.808

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_S92_E3.6161.00
42_W46_F2.9581.00
42_W45_L2.8261.00
171_L176_L2.1371.00
56_G60_P2.0841.00
219_L223_L2.0371.00
37_P40_L2.0331.00
41_G44_G1.9431.00
191_W194_R1.9431.00
131_L134_L1.9311.00
92_E96_G1.9201.00
43_D46_F1.9071.00
194_R197_P1.9001.00
197_P200_Y1.8991.00
172_L175_G1.8971.00
125_G128_P1.8491.00
126_L129_L1.7631.00
184_G187_L1.7491.00
123_L126_L1.7271.00
24_L28_G1.7161.00
127_G130_G1.6961.00
91_W95_L1.6911.00
106_L141_L1.6741.00
74_E97_K1.6701.00
14_W20_P1.6691.00
216_A219_L1.6661.00
24_L27_F1.6661.00
181_L185_F1.6441.00
83_L93_I1.6421.00
41_G46_F1.6331.00
17_L20_P1.6161.00
216_A224_L1.6021.00
101_A148_A1.5991.00
78_G81_E1.5921.00
178_L186_W1.5821.00
218_L222_L1.5631.00
181_L186_W1.5561.00
180_L183_L1.5411.00
178_L182_L1.5401.00
171_L175_G1.5341.00
193_S197_P1.5321.00
124_G127_G1.5311.00
13_L20_P1.5301.00
207_G210_L1.5291.00
220_V224_L1.5241.00
177_F181_L1.5031.00
180_L184_G1.4961.00
200_Y203_L1.4771.00
75_R80_L1.4761.00
179_L183_L1.4531.00
181_L184_G1.4451.00
200_Y204_P1.4321.00
96_G100_A1.4231.00
102_L145_L1.3991.00
5_R9_R1.3981.00
84_L90_R1.3971.00
172_L176_L1.3961.00
183_L186_W1.3941.00
211_G214_G1.3921.00
197_P201_G1.3781.00
216_A220_V1.3711.00
207_G211_G1.3701.00
121_L124_G1.3421.00
218_L221_L1.3411.00
82_L85_T1.3401.00
5_R8_F1.3341.00
198_L201_G1.3161.00
98_F149_A1.3151.00
170_L175_G1.3141.00
204_P207_G1.3111.00
206_R209_L1.3031.00
122_L125_G1.3011.00
179_L186_W1.2841.00
191_W195_L1.2701.00
4_L100_A1.2571.00
66_L69_L1.2541.00
178_L183_L1.2521.00
220_V223_L1.2501.00
160_N163_V1.2501.00
25_L28_G1.2401.00
53_G56_G1.2401.00
197_P204_P1.2391.00
12_I15_I1.2371.00
182_L186_W1.2171.00
195_L199_L1.2151.00
194_R198_L1.2141.00
32_L35_G1.2091.00
170_L174_L1.2081.00
32_L36_Q1.2011.00
192_L197_P1.1811.00
23_F28_G1.1691.00
116_A120_G1.1681.00
171_L174_L1.1611.00
204_P211_G1.1571.00
191_W197_P1.1431.00
179_L184_G1.1361.00
182_L187_L1.1351.00
64_A67_T1.1351.00
193_S200_Y1.1311.00
158_T163_V1.1301.00
80_L84_L1.1181.00
168_G171_L1.1111.00
203_L206_R1.1111.00
209_L212_G1.1091.00
219_L222_L1.1051.00
183_L187_L1.0981.00
14_W17_L1.0951.00
195_L198_L1.0911.00
169_L176_L1.0901.00
125_G130_G1.0851.00
208_F211_G1.0751.00
204_P208_F1.0751.00
205_L208_F1.0691.00
169_L172_L1.0691.00
200_Y207_G1.0671.00
64_A68_A1.0671.00
169_L175_G1.0631.00
52_P56_G1.0621.00
193_S198_L1.0611.00
180_L186_W1.0521.00
140_L143_L1.0431.00
194_R199_L1.0251.00
194_R200_Y1.0231.00
22_L26_L1.0221.00
124_G128_P1.0211.00
199_L203_L1.0201.00
13_L17_L1.0081.00
178_L181_L1.0041.00
126_L130_G1.0031.00
219_L224_L1.0031.00
41_G45_L1.0001.00
221_L224_L0.9971.00
33_F36_Q0.9931.00
125_G129_L0.9921.00
124_G129_L0.9811.00
21_L28_G0.9791.00
116_A119_A0.9771.00
11_R14_W0.9771.00
8_F11_R0.9751.00
23_F27_F0.9711.00
192_L198_L0.9701.00
203_L207_G0.9641.00
196_L200_Y0.9631.00
205_L210_L0.9601.00
206_R210_L0.9601.00
216_A221_L0.9571.00
55_I59_L0.9521.00
196_L201_G0.9511.00
75_R159_R0.9511.00
192_L195_L0.9441.00
20_P24_L0.9421.00
177_F180_L0.9411.00
201_G207_G0.9381.00
195_L200_Y0.9241.00
21_L25_L0.9231.00
130_G133_L0.9061.00
210_L213_S0.9061.00
188_P191_W0.9051.00
154_I158_T0.9041.00
23_F26_L0.9011.00
74_E79_T0.9001.00
181_L187_L0.8981.00
201_G206_R0.8981.00
54_L58_L0.8941.00
202_V206_R0.8941.00
164_A168_G0.8931.00
204_P210_L0.8931.00
14_W18_L0.8931.00
110_L137_L0.8831.00
164_A167_L0.8821.00
199_L204_P0.8751.00
4_L8_F0.8741.00
140_L144_L0.8711.00
139_L143_L0.8671.00
201_G204_P0.8611.00
198_L202_V0.8601.00
149_A153_L0.8571.00
218_L224_L0.8561.00
200_Y206_R0.8521.00
56_G59_L0.8511.00
150_L154_I0.8481.00
98_F102_L0.8481.00
182_L185_F0.8401.00
194_R201_G0.8381.00
165_I168_G0.8341.00
207_G213_S0.8311.00
29_A33_F0.8311.00
198_L204_P0.8291.00
166_G169_L0.8251.00
212_G215_L0.8221.00
180_L185_F0.8171.00
83_L86_T0.8141.00
123_L128_P0.8131.00
196_L199_L0.8081.00
196_L203_L0.8021.00
210_L215_L0.8001.00
193_S196_L0.7911.00
123_L127_G0.7881.00
153_L157_L0.7841.00
121_L126_L0.7821.00
207_G212_G0.7771.00
193_S199_L0.7751.00
138_L142_L0.7741.00
200_Y211_G0.7741.00
118_L121_L0.7701.00
203_L210_L0.7671.00
203_L209_L0.7621.00
83_L87_P0.7621.00
169_L174_L0.7611.00
209_L213_S0.7591.00
88_V93_I0.7581.00
73_R77_R0.7531.00
142_L146_A0.7501.00
204_P213_S0.7421.00
202_V205_L0.7411.00
69_L73_R0.7401.00
197_P203_L0.7391.00
210_L214_G0.7341.00
153_L156_T0.7321.00
45_L49_F0.7271.00
177_F184_G0.7251.00
204_P214_G0.7211.00
145_L149_A0.7121.00
191_W196_L0.7121.00
73_R76_E0.7081.00
170_L176_L0.7041.00
123_L130_G0.7011.00
199_L202_V0.7001.00
123_L129_L0.7001.00
178_L184_G0.7001.00
20_P23_F0.6981.00
179_L187_L0.6961.00
203_L208_F0.6941.00
88_V92_E0.6931.00
82_L86_T0.6921.00
30_A34_S0.6891.00
98_F152_L0.6881.00
211_G215_L0.6811.00
191_W198_L0.6801.00
21_L24_L0.6801.00
15_I18_L0.6781.00
143_L146_A0.6761.00
13_L16_L0.6741.00
207_G214_G0.6681.00
102_L141_L0.6651.00
195_L201_G0.6641.00
63_I67_T0.6581.00
202_V207_G0.6561.00
53_G57_L0.6531.00
168_G172_L0.6471.00
192_L196_L0.6471.00
199_L210_L0.6431.00
12_I16_L0.6421.00
4_L103_L0.6371.00
128_P131_L0.6301.00
201_G205_L0.6301.00
143_L147_F0.6301.00
31_A34_S0.6251.00
55_I58_L0.6241.00
15_I19_L0.6231.00
60_P63_I0.6201.00
208_F213_S0.6191.00
95_L99_L0.6171.00
3_E97_K0.6161.00
163_V167_L0.6131.00
129_L132_G0.6131.00
108_L112_T0.6121.00
15_I20_P0.6081.00
193_S201_G0.6081.00
104_L108_L0.6071.00
191_W200_Y0.6071.00
12_I20_P0.6031.00
122_L126_L0.6031.00
205_L209_L0.6011.00
179_L182_L0.5971.00
190_A194_R0.5921.00
162_A166_G0.5871.00
111_L114_L0.5861.00
84_L93_I0.5821.00
196_L202_V0.5821.00
52_P55_I0.5801.00
218_L223_L0.5781.00
141_L144_L0.5761.00
201_G208_F0.5751.00
118_L122_L0.5721.00
198_L203_L0.5671.00
179_L185_F0.5651.00
166_G170_L0.5631.00
29_A35_G0.5621.00
202_V211_G0.5571.00
204_P212_G0.5571.00
64_A69_L0.5551.00
200_Y210_L0.5531.00
216_A223_L0.5531.00
208_F212_G0.5491.00
14_W19_L0.5471.00
119_A122_L0.5461.00
121_L128_P0.5461.00
194_R203_L0.5431.00
168_G175_G0.5391.00
152_L155_S0.5371.00
208_F214_G0.5311.00
16_L19_L0.5281.00
155_S159_R0.5271.00
29_A32_L0.5251.00
192_L199_L0.5241.00
122_L128_P0.5221.00
197_P205_L0.5201.00
117_L121_L0.5191.00
24_L29_A0.5191.00
7_L11_R0.5181.00
137_L140_L0.5181.00
108_L111_L0.5171.00
170_L173_L0.5121.00
178_L187_L0.5121.00
201_G211_G0.5111.00
135_L139_L0.5101.00
197_P202_V0.5101.00
204_P209_L0.5091.00
200_Y209_L0.5091.00
31_A35_G0.5081.00
22_L27_F0.5041.00
22_L25_L0.5041.00
177_F183_L0.5031.00
53_G60_P0.5011.00
191_W199_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4us3A 1 0.4609 5.5 0.907 Contact Map
2a65A 2 0.6435 3.1 0.917 Contact Map
4qinA 2 0.3565 2.1 0.924 Contact Map
1qleD 1 0.187 1.9 0.926 Contact Map
3hd7A 1 0.1348 1.9 0.926 Contact Map
4jkvA 2 0.3609 1.8 0.927 Contact Map
2wswA 3 0.2826 1.7 0.928 Contact Map
4rndA 2 0.0348 1.5 0.93 Contact Map
1wjxA 1 0.1783 1.5 0.93 Contact Map
4w8yA 1 0.2435 1.5 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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