DUF3801 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF3801 - Protein of unknown function (DUF3801)

PFAM:	PF12687	Sequences: AKNLAALLYAVLKDQKKTKGKTRLTNMLKSGKELKVFSVKEEDLKKFAKEAKKYGVLYCVLRDKKNKDGLVDIMVRAEDASKINRIVERFKLATVDTASIKEIEKEKAKTEEAAPEKGAPEKSKEDKLLDELLGKPLQKEEAAKTEKSPPSEPSSESRSKSAEGTTERPSVREELKEIKAEQKEKEAEKPEKTKHKQKKKKKKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	204 (200)
Sequences:	742 (627)
Seq/√Len:	44.3
META:	0.88

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
195_H	198_K	3.326	1.00
174_E	178_I	3.152	1.00
102_E	105_K	2.942	1.00
103_I	107_K	2.782	1.00
1_A	5_A	2.549	1.00
173_E	176_K	2.409	1.00
22_T	57_L	2.288	1.00
116_E	119_A	2.197	1.00
46_K	49_K	2.168	1.00
129_L	133_L	2.113	1.00
79_D	82_K	2.069	0.99
76_R	82_K	2.043	0.99
35_K	81_S	2.026	0.99
33_E	77_A	2.022	0.99
128_L	132_L	2.017	0.99
126_D	130_D	2.010	0.99
45_K	49_K	1.979	0.99
151_S	155_S	1.952	0.99
130_D	133_L	1.926	0.99
40_K	43_D	1.904	0.99
126_D	129_L	1.898	0.99
171_V	175_L	1.892	0.99
190_P	193_T	1.884	0.99
135_K	138_Q	1.875	0.99
50_E	53_K	1.867	0.99
41_E	71_V	1.827	0.99
103_I	106_E	1.797	0.98
112_E	117_K	1.760	0.98
35_K	77_A	1.748	0.98
27_M	76_R	1.742	0.98
53_K	87_V	1.687	0.98
96_D	100_I	1.653	0.97
192_K	195_H	1.593	0.97
72_D	90_F	1.586	0.96
16_K	57_L	1.584	0.96
142_A	145_T	1.564	0.96
162_A	165_T	1.558	0.96
56_V	86_I	1.557	0.96
183_K	186_E	1.555	0.96
172_R	178_I	1.516	0.95
154_S	158_R	1.513	0.95
44_L	74_M	1.507	0.95
191_E	194_K	1.498	0.95
193_T	197_Q	1.491	0.95
33_E	56_V	1.476	0.95
170_S	175_L	1.450	0.94
104_E	108_A	1.424	0.94
35_K	56_V	1.397	0.93
56_V	82_K	1.392	0.93
193_T	198_K	1.388	0.93
150_P	155_S	1.377	0.92
195_H	199_K	1.376	0.92
1_A	6_A	1.359	0.92
12_L	39_V	1.354	0.92
152_E	155_S	1.348	0.92
141_E	180_A	1.343	0.91
7_L	10_A	1.340	0.91
22_T	26_N	1.339	0.91
105_K	108_A	1.337	0.91
192_K	198_K	1.332	0.91
77_A	82_K	1.329	0.91
160_K	165_T	1.329	0.91
169_P	177_E	1.323	0.91
116_E	122_K	1.304	0.90
118_G	124_K	1.299	0.90
75_V	85_R	1.286	0.89
35_K	80_A	1.283	0.89
132_L	136_P	1.275	0.89
3_N	6_A	1.271	0.89
129_L	132_L	1.269	0.89
9_Y	14_D	1.264	0.89
28_L	34_L	1.263	0.89
133_L	136_P	1.261	0.89
154_S	163_E	1.252	0.88
43_D	54_Y	1.250	0.88
60_V	71_V	1.217	0.87
191_E	197_Q	1.210	0.86
194_K	197_Q	1.197	0.86
72_D	89_R	1.194	0.86
53_K	56_V	1.192	0.86
152_E	159_S	1.191	0.85
126_D	132_L	1.187	0.85
147_K	152_E	1.178	0.85
133_L	139_K	1.172	0.85
181_E	185_K	1.163	0.84
193_T	196_K	1.160	0.84
6_A	9_Y	1.151	0.83
114_A	117_K	1.148	0.83
118_G	122_K	1.143	0.83
4_L	36_V	1.133	0.82
168_R	172_R	1.131	0.82
69_G	74_M	1.129	0.82
15_Q	18_T	1.126	0.82
33_E	81_S	1.110	0.81
176_K	179_K	1.101	0.81
76_R	79_D	1.098	0.80
33_E	36_V	1.092	0.80
184_E	188_E	1.089	0.80
36_V	54_Y	1.084	0.80
40_K	70_L	1.084	0.80
131_E	136_P	1.069	0.79
19_K	24_L	1.064	0.78
33_E	78_E	1.045	0.77
32_K	78_E	1.043	0.77
172_R	176_K	1.041	0.77
14_D	22_T	1.039	0.77
150_P	153_P	1.033	0.76
46_K	90_F	1.008	0.74
121_E	124_K	0.998	0.74
3_N	11_V	0.998	0.74
112_E	122_K	0.991	0.73
30_S	76_R	0.964	0.71
5_A	8_L	0.957	0.70
53_K	63_D	0.950	0.70
64_K	67_K	0.944	0.69
32_K	82_K	0.939	0.69
128_L	137_L	0.937	0.69
181_E	184_E	0.933	0.68
7_L	19_K	0.933	0.68
11_V	14_D	0.931	0.68
18_T	57_L	0.926	0.68
47_F	170_S	0.923	0.68
178_I	182_Q	0.920	0.67
14_D	18_T	0.918	0.67
103_I	108_A	0.911	0.67
117_K	122_K	0.909	0.66
147_K	151_S	0.907	0.66
36_V	81_S	0.904	0.66
63_D	74_M	0.903	0.66
65_K	91_K	0.899	0.66
117_K	123_S	0.898	0.65
146_E	149_P	0.897	0.65
102_E	107_K	0.895	0.65
194_K	198_K	0.890	0.65
31_G	36_V	0.884	0.64
154_S	160_K	0.879	0.64
73_I	91_K	0.875	0.63
44_L	71_V	0.872	0.63
38_S	81_S	0.872	0.63
16_K	19_K	0.871	0.63
192_K	197_Q	0.867	0.63
182_Q	185_K	0.857	0.62
47_F	51_A	0.856	0.62
80_A	85_R	0.853	0.61
112_E	116_E	0.851	0.61
122_K	126_D	0.848	0.61
2_K	29_K	0.846	0.61
62_R	65_K	0.844	0.61
127_K	131_E	0.842	0.60
5_A	9_Y	0.840	0.60
134_G	137_L	0.831	0.59
18_T	172_R	0.825	0.59
23_R	59_C	0.823	0.59
189_K	194_K	0.823	0.59
36_V	78_E	0.823	0.59
17_K	57_L	0.819	0.58
122_K	139_K	0.811	0.58
4_L	71_V	0.805	0.57
191_E	198_K	0.805	0.57
102_E	106_E	0.803	0.57
37_F	84_N	0.800	0.57
90_F	93_A	0.796	0.56
125_E	128_L	0.796	0.56
122_K	125_E	0.795	0.56
126_D	131_E	0.795	0.56
110_T	118_G	0.792	0.56
158_R	162_A	0.787	0.55
30_S	83_I	0.787	0.55
144_K	156_E	0.784	0.55
143_A	147_K	0.783	0.55
180_A	184_E	0.780	0.55
79_D	85_R	0.775	0.54
35_K	39_V	0.769	0.54
92_L	95_V	0.766	0.53
113_A	131_E	0.765	0.53
128_L	134_G	0.764	0.53
173_E	177_E	0.762	0.53
182_Q	186_E	0.758	0.53
116_E	123_S	0.758	0.53
34_L	76_R	0.756	0.52
24_L	30_S	0.754	0.52
147_K	164_G	0.754	0.52
130_D	136_P	0.750	0.52
14_D	57_L	0.749	0.52
138_Q	156_E	0.748	0.52
116_E	120_P	0.747	0.51
35_K	92_L	0.744	0.51
28_L	35_K	0.736	0.50
149_P	155_S	0.736	0.50
7_L	11_V	0.731	0.50
35_K	38_S	0.731	0.50
41_E	60_V	0.726	0.49
6_A	12_L	0.722	0.49
162_A	166_T	0.720	0.49
31_G	78_E	0.719	0.49
2_K	10_A	0.717	0.49
117_K	120_P	0.714	0.48
30_S	61_L	0.711	0.48
121_E	127_K	0.710	0.48
11_V	15_Q	0.703	0.47
153_P	161_S	0.703	0.47
62_R	71_V	0.703	0.47
154_S	157_S	0.698	0.47
127_K	139_K	0.696	0.47
54_Y	79_D	0.694	0.46
6_A	18_T	0.693	0.46
196_K	199_K	0.691	0.46
33_E	75_V	0.690	0.46
36_V	96_D	0.687	0.46
159_S	162_A	0.687	0.46
114_A	124_K	0.683	0.45
75_V	79_D	0.680	0.45
93_A	100_I	0.678	0.45
192_K	196_K	0.678	0.45
131_E	134_G	0.668	0.44
165_T	185_K	0.668	0.44
60_V	100_I	0.667	0.44
34_L	78_E	0.667	0.44
3_N	73_I	0.664	0.43
122_K	127_K	0.658	0.43
132_L	137_L	0.656	0.43
176_K	180_A	0.656	0.43
157_S	161_S	0.654	0.43
7_L	38_S	0.654	0.43
111_E	122_K	0.654	0.43
21_K	57_L	0.651	0.42
115_P	118_G	0.650	0.42
26_N	30_S	0.648	0.42
151_S	162_A	0.644	0.42
147_K	153_P	0.642	0.41
79_D	83_I	0.641	0.41
62_R	101_K	0.639	0.41
24_L	78_E	0.637	0.41
67_K	70_L	0.633	0.41
112_E	121_E	0.627	0.40
120_P	129_L	0.622	0.40
149_P	164_G	0.619	0.39
149_P	162_A	0.619	0.39
34_L	89_R	0.619	0.39
128_L	133_L	0.618	0.39
146_E	150_P	0.618	0.39
169_P	174_E	0.617	0.39
70_L	101_K	0.614	0.39
197_Q	200_K	0.614	0.39
41_E	62_R	0.612	0.39
154_S	164_G	0.606	0.38
194_K	199_K	0.606	0.38
122_K	131_E	0.599	0.37
41_E	70_L	0.596	0.37
56_V	72_D	0.591	0.37
112_E	120_P	0.586	0.36
109_K	112_E	0.585	0.36
172_R	179_K	0.585	0.36
31_G	95_V	0.583	0.36
30_S	34_L	0.577	0.35
181_E	186_E	0.572	0.35
128_L	136_P	0.572	0.35
4_L	16_K	0.572	0.35
24_L	47_F	0.565	0.34
7_L	25_T	0.560	0.34
114_A	118_G	0.558	0.34
50_E	85_R	0.552	0.33
150_P	154_S	0.552	0.33
185_K	192_K	0.551	0.33
176_K	199_K	0.551	0.33
152_E	157_S	0.549	0.33
6_A	11_V	0.548	0.33
125_E	129_L	0.548	0.33
34_L	74_M	0.544	0.33
50_E	86_I	0.543	0.33
63_D	66_N	0.540	0.32
27_M	34_L	0.540	0.32
144_K	152_E	0.537	0.32
32_K	81_S	0.537	0.32
121_E	132_L	0.537	0.32
54_Y	83_I	0.534	0.32
46_K	57_L	0.534	0.32
62_R	67_K	0.532	0.32
96_D	99_S	0.527	0.31
29_K	44_L	0.527	0.31
126_D	133_L	0.527	0.31
110_T	114_A	0.526	0.31
22_T	27_M	0.525	0.31
44_L	61_L	0.525	0.31
33_E	82_K	0.523	0.31
41_E	87_V	0.522	0.31
193_T	199_K	0.521	0.31
136_P	140_E	0.520	0.31
11_V	23_R	0.518	0.30
154_S	161_S	0.517	0.30
6_A	15_Q	0.513	0.30
62_R	82_K	0.508	0.30
189_K	192_K	0.507	0.30
148_S	155_S	0.506	0.29
113_A	119_A	0.505	0.29
4_L	13_K	0.503	0.29
124_K	127_K	0.502	0.29
129_L	136_P	0.502	0.29
41_E	53_K	0.501	0.29
56_V	81_S	0.500	0.29

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1wn2A	2	0.4559	43.9	0.925	Contact Map
2lndA	1	0.4412	40.5	0.927	Contact Map
2ohwA	1	0.4608	36.4	0.929	Contact Map
2zv3A	2	0.4559	36.2	0.929	Contact Map
3v7qA	1	0.4412	33.7	0.93	Contact Map
1xtyA	2	0.4559	33.6	0.93	Contact Map
1rlkA	2	0.4559	30.4	0.931	Contact Map
1q7sA	2	0.4559	26	0.933	Contact Map
4nutA	1	0.4804	23.6	0.935	Contact Map
1rzwA	1	0.4951	21.4	0.936	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0079 seconds.