GREMLIN Database
DUF3801 - Protein of unknown function (DUF3801)
PFAM: PF12687 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 204 (200)
Sequences: 742 (627)
Seq/√Len: 44.3
META: 0.88

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_H198_K3.3261.00
174_E178_I3.1521.00
102_E105_K2.9421.00
103_I107_K2.7821.00
1_A5_A2.5491.00
173_E176_K2.4091.00
22_T57_L2.2881.00
116_E119_A2.1971.00
46_K49_K2.1681.00
129_L133_L2.1131.00
79_D82_K2.0690.99
76_R82_K2.0430.99
35_K81_S2.0260.99
33_E77_A2.0220.99
128_L132_L2.0170.99
126_D130_D2.0100.99
45_K49_K1.9790.99
151_S155_S1.9520.99
130_D133_L1.9260.99
40_K43_D1.9040.99
126_D129_L1.8980.99
171_V175_L1.8920.99
190_P193_T1.8840.99
135_K138_Q1.8750.99
50_E53_K1.8670.99
41_E71_V1.8270.99
103_I106_E1.7970.98
112_E117_K1.7600.98
35_K77_A1.7480.98
27_M76_R1.7420.98
53_K87_V1.6870.98
96_D100_I1.6530.97
192_K195_H1.5930.97
72_D90_F1.5860.96
16_K57_L1.5840.96
142_A145_T1.5640.96
162_A165_T1.5580.96
56_V86_I1.5570.96
183_K186_E1.5550.96
172_R178_I1.5160.95
154_S158_R1.5130.95
44_L74_M1.5070.95
191_E194_K1.4980.95
193_T197_Q1.4910.95
33_E56_V1.4760.95
170_S175_L1.4500.94
104_E108_A1.4240.94
35_K56_V1.3970.93
56_V82_K1.3920.93
193_T198_K1.3880.93
150_P155_S1.3770.92
195_H199_K1.3760.92
1_A6_A1.3590.92
12_L39_V1.3540.92
152_E155_S1.3480.92
141_E180_A1.3430.91
7_L10_A1.3400.91
22_T26_N1.3390.91
105_K108_A1.3370.91
192_K198_K1.3320.91
77_A82_K1.3290.91
160_K165_T1.3290.91
169_P177_E1.3230.91
116_E122_K1.3040.90
118_G124_K1.2990.90
75_V85_R1.2860.89
35_K80_A1.2830.89
132_L136_P1.2750.89
3_N6_A1.2710.89
129_L132_L1.2690.89
9_Y14_D1.2640.89
28_L34_L1.2630.89
133_L136_P1.2610.89
154_S163_E1.2520.88
43_D54_Y1.2500.88
60_V71_V1.2170.87
191_E197_Q1.2100.86
194_K197_Q1.1970.86
72_D89_R1.1940.86
53_K56_V1.1920.86
152_E159_S1.1910.85
126_D132_L1.1870.85
147_K152_E1.1780.85
133_L139_K1.1720.85
181_E185_K1.1630.84
193_T196_K1.1600.84
6_A9_Y1.1510.83
114_A117_K1.1480.83
118_G122_K1.1430.83
4_L36_V1.1330.82
168_R172_R1.1310.82
69_G74_M1.1290.82
15_Q18_T1.1260.82
33_E81_S1.1100.81
176_K179_K1.1010.81
76_R79_D1.0980.80
33_E36_V1.0920.80
184_E188_E1.0890.80
36_V54_Y1.0840.80
40_K70_L1.0840.80
131_E136_P1.0690.79
19_K24_L1.0640.78
33_E78_E1.0450.77
32_K78_E1.0430.77
172_R176_K1.0410.77
14_D22_T1.0390.77
150_P153_P1.0330.76
46_K90_F1.0080.74
121_E124_K0.9980.74
3_N11_V0.9980.74
112_E122_K0.9910.73
30_S76_R0.9640.71
5_A8_L0.9570.70
53_K63_D0.9500.70
64_K67_K0.9440.69
32_K82_K0.9390.69
128_L137_L0.9370.69
181_E184_E0.9330.68
7_L19_K0.9330.68
11_V14_D0.9310.68
18_T57_L0.9260.68
47_F170_S0.9230.68
178_I182_Q0.9200.67
14_D18_T0.9180.67
103_I108_A0.9110.67
117_K122_K0.9090.66
147_K151_S0.9070.66
36_V81_S0.9040.66
63_D74_M0.9030.66
65_K91_K0.8990.66
117_K123_S0.8980.65
146_E149_P0.8970.65
102_E107_K0.8950.65
194_K198_K0.8900.65
31_G36_V0.8840.64
154_S160_K0.8790.64
73_I91_K0.8750.63
44_L71_V0.8720.63
38_S81_S0.8720.63
16_K19_K0.8710.63
192_K197_Q0.8670.63
182_Q185_K0.8570.62
47_F51_A0.8560.62
80_A85_R0.8530.61
112_E116_E0.8510.61
122_K126_D0.8480.61
2_K29_K0.8460.61
62_R65_K0.8440.61
127_K131_E0.8420.60
5_A9_Y0.8400.60
134_G137_L0.8310.59
18_T172_R0.8250.59
23_R59_C0.8230.59
189_K194_K0.8230.59
36_V78_E0.8230.59
17_K57_L0.8190.58
122_K139_K0.8110.58
4_L71_V0.8050.57
191_E198_K0.8050.57
102_E106_E0.8030.57
37_F84_N0.8000.57
90_F93_A0.7960.56
125_E128_L0.7960.56
122_K125_E0.7950.56
126_D131_E0.7950.56
110_T118_G0.7920.56
158_R162_A0.7870.55
30_S83_I0.7870.55
144_K156_E0.7840.55
143_A147_K0.7830.55
180_A184_E0.7800.55
79_D85_R0.7750.54
35_K39_V0.7690.54
92_L95_V0.7660.53
113_A131_E0.7650.53
128_L134_G0.7640.53
173_E177_E0.7620.53
182_Q186_E0.7580.53
116_E123_S0.7580.53
34_L76_R0.7560.52
24_L30_S0.7540.52
147_K164_G0.7540.52
130_D136_P0.7500.52
14_D57_L0.7490.52
138_Q156_E0.7480.52
116_E120_P0.7470.51
35_K92_L0.7440.51
28_L35_K0.7360.50
149_P155_S0.7360.50
7_L11_V0.7310.50
35_K38_S0.7310.50
41_E60_V0.7260.49
6_A12_L0.7220.49
162_A166_T0.7200.49
31_G78_E0.7190.49
2_K10_A0.7170.49
117_K120_P0.7140.48
30_S61_L0.7110.48
121_E127_K0.7100.48
11_V15_Q0.7030.47
153_P161_S0.7030.47
62_R71_V0.7030.47
154_S157_S0.6980.47
127_K139_K0.6960.47
54_Y79_D0.6940.46
6_A18_T0.6930.46
196_K199_K0.6910.46
33_E75_V0.6900.46
36_V96_D0.6870.46
159_S162_A0.6870.46
114_A124_K0.6830.45
75_V79_D0.6800.45
93_A100_I0.6780.45
192_K196_K0.6780.45
131_E134_G0.6680.44
165_T185_K0.6680.44
60_V100_I0.6670.44
34_L78_E0.6670.44
3_N73_I0.6640.43
122_K127_K0.6580.43
132_L137_L0.6560.43
176_K180_A0.6560.43
157_S161_S0.6540.43
7_L38_S0.6540.43
111_E122_K0.6540.43
21_K57_L0.6510.42
115_P118_G0.6500.42
26_N30_S0.6480.42
151_S162_A0.6440.42
147_K153_P0.6420.41
79_D83_I0.6410.41
62_R101_K0.6390.41
24_L78_E0.6370.41
67_K70_L0.6330.41
112_E121_E0.6270.40
120_P129_L0.6220.40
149_P164_G0.6190.39
149_P162_A0.6190.39
34_L89_R0.6190.39
128_L133_L0.6180.39
146_E150_P0.6180.39
169_P174_E0.6170.39
70_L101_K0.6140.39
197_Q200_K0.6140.39
41_E62_R0.6120.39
154_S164_G0.6060.38
194_K199_K0.6060.38
122_K131_E0.5990.37
41_E70_L0.5960.37
56_V72_D0.5910.37
112_E120_P0.5860.36
109_K112_E0.5850.36
172_R179_K0.5850.36
31_G95_V0.5830.36
30_S34_L0.5770.35
181_E186_E0.5720.35
128_L136_P0.5720.35
4_L16_K0.5720.35
24_L47_F0.5650.34
7_L25_T0.5600.34
114_A118_G0.5580.34
50_E85_R0.5520.33
150_P154_S0.5520.33
185_K192_K0.5510.33
176_K199_K0.5510.33
152_E157_S0.5490.33
6_A11_V0.5480.33
125_E129_L0.5480.33
34_L74_M0.5440.33
50_E86_I0.5430.33
63_D66_N0.5400.32
27_M34_L0.5400.32
144_K152_E0.5370.32
32_K81_S0.5370.32
121_E132_L0.5370.32
54_Y83_I0.5340.32
46_K57_L0.5340.32
62_R67_K0.5320.32
96_D99_S0.5270.31
29_K44_L0.5270.31
126_D133_L0.5270.31
110_T114_A0.5260.31
22_T27_M0.5250.31
44_L61_L0.5250.31
33_E82_K0.5230.31
41_E87_V0.5220.31
193_T199_K0.5210.31
136_P140_E0.5200.31
11_V23_R0.5180.30
154_S161_S0.5170.30
6_A15_Q0.5130.30
62_R82_K0.5080.30
189_K192_K0.5070.30
148_S155_S0.5060.29
113_A119_A0.5050.29
4_L13_K0.5030.29
124_K127_K0.5020.29
129_L136_P0.5020.29
41_E53_K0.5010.29
56_V81_S0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wn2A 2 0.4559 43.9 0.925 Contact Map
2lndA 1 0.4412 40.5 0.927 Contact Map
2ohwA 1 0.4608 36.4 0.929 Contact Map
2zv3A 2 0.4559 36.2 0.929 Contact Map
3v7qA 1 0.4412 33.7 0.93 Contact Map
1xtyA 2 0.4559 33.6 0.93 Contact Map
1rlkA 2 0.4559 30.4 0.931 Contact Map
1q7sA 2 0.4559 26 0.933 Contact Map
4nutA 1 0.4804 23.6 0.935 Contact Map
1rzwA 1 0.4951 21.4 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0228 seconds.