GREMLIN Database
DUF3800 - Protein of unknown function (DUF3800)
PFAM: PF12686 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 235 (209)
Sequences: 14232 (12764)
Seq/√Len: 882.9
META: 0.888

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_G204_A4.7921.00
61_A205_G3.8831.00
208_R212_E2.8041.00
47_K85_D2.7941.00
79_R82_L2.4311.00
152_D191_S2.3271.00
189_V194_S2.3131.00
104_K107_L2.2981.00
23_V204_A2.2961.00
23_V208_R2.2761.00
190_D193_E2.2751.00
2_I28_I2.2231.00
42_R195_P2.1331.00
89_L93_L2.0671.00
189_V197_L2.0641.00
45_K195_P2.0531.00
33_D36_E1.9391.00
40_E93_L1.9351.00
38_E195_P1.9261.00
7_S23_V1.8961.00
2_I26_G1.8931.00
75_S78_K1.8421.00
38_E42_R1.7941.00
103_V106_K1.7901.00
27_V200_A1.7861.00
2_I147_G1.7561.00
74_L78_K1.7391.00
103_V107_L1.7391.00
78_K81_R1.6891.00
30_P33_D1.6621.00
36_E40_E1.6471.00
71_F74_L1.6471.00
48_L85_D1.6331.00
162_L166_L1.6171.00
44_L48_L1.6031.00
60_H64_I1.6001.00
118_P121_P1.5901.00
74_L79_R1.5761.00
39_K43_E1.5501.00
131_L134_E1.5471.00
159_D163_E1.5391.00
76_D80_R1.5371.00
75_S82_L1.5291.00
101_V104_K1.5241.00
61_A65_R1.4821.00
173_G176_Y1.4801.00
127_Y131_L1.4301.00
4_I26_G1.4291.00
155_G159_D1.4281.00
158_E161_K1.3961.00
155_G158_E1.3891.00
97_I103_V1.3851.00
75_S79_R1.3801.00
60_H63_K1.3781.00
43_E47_K1.3781.00
130_R134_E1.3521.00
205_G209_R1.3511.00
153_S159_D1.3281.00
105_K108_L1.3211.00
100_A103_V1.3151.00
154_R159_D1.3121.00
156_K159_D1.3091.00
61_A64_I1.3031.00
40_E43_E1.3021.00
40_E92_K1.2891.00
170_I173_G1.2881.00
44_L47_K1.2721.00
154_R158_E1.2561.00
34_W38_E1.2551.00
148_I185_D1.2511.00
59_L64_I1.2471.00
83_L87_L1.2461.00
114_D117_D1.2141.00
115_N118_P1.2081.00
85_D88_D1.2061.00
99_A104_K1.1911.00
148_I187_F1.1881.00
78_K82_L1.1801.00
184_E187_F1.1781.00
41_I45_K1.1771.00
171_L174_T1.1721.00
156_K160_R1.1691.00
45_K48_L1.1691.00
136_L147_G1.1661.00
96_L104_K1.1601.00
64_I68_K1.1501.00
131_L135_R1.1481.00
100_A104_K1.1471.00
85_D89_L1.1451.00
50_G54_V1.1391.00
77_E81_R1.1371.00
27_V203_V1.1341.00
9_D19_S1.1231.00
146_R184_E1.1221.00
125_Y129_L1.1221.00
109_D112_A1.1201.00
25_G203_V1.1141.00
108_L111_Y1.1081.00
8_G208_R1.1051.00
40_E89_L1.0931.00
64_I202_L1.0901.00
139_F143_P1.0781.00
99_A103_V1.0781.00
39_K42_R1.0731.00
132_L136_L1.0661.00
160_R163_E1.0661.00
20_P212_E1.0641.00
107_L111_Y1.0621.00
62_S68_K1.0611.00
44_L89_L1.0521.00
125_Y128_A1.0441.00
209_R213_R1.0371.00
38_E196_G1.0281.00
148_I184_E1.0271.00
6_E22_F1.0241.00
42_R46_R1.0231.00
97_I104_K1.0201.00
105_K109_D1.0031.00
35_R39_K0.9871.00
74_L77_E0.9861.00
150_I187_F0.9811.00
128_A131_L0.9711.00
73_G82_L0.9601.00
76_D79_R0.9591.00
37_L41_I0.9531.00
200_A204_A0.9401.00
100_A207_I0.9381.00
150_I189_V0.9381.00
44_L85_D0.9371.00
19_S208_R0.9351.00
160_R164_E0.9321.00
74_L82_L0.9271.00
89_L92_K0.9251.00
77_E80_R0.9241.00
127_Y130_R0.9231.00
170_I174_T0.9171.00
107_L110_K0.9101.00
154_R157_K0.9081.00
162_L165_Y0.9051.00
88_D91_A0.9041.00
189_V193_E0.9011.00
4_I132_L0.8991.00
97_I100_A0.8911.00
87_L91_A0.8901.00
159_D162_L0.8901.00
87_L90_L0.8891.00
34_W196_G0.8861.00
188_F191_S0.8811.00
84_K87_L0.8741.00
158_E165_Y0.8701.00
123_Y126_K0.8681.00
161_K165_Y0.8671.00
182_I186_I0.8661.00
164_E167_R0.8651.00
73_G78_K0.8621.00
3_Y34_W0.8571.00
27_V199_L0.8571.00
77_E82_L0.8561.00
29_V34_W0.8521.00
153_S158_E0.8491.00
102_I107_L0.8271.00
37_L196_G0.8261.00
110_K113_L0.8241.00
98_F101_V0.8201.00
130_R133_L0.8161.00
187_F190_D0.8121.00
103_V111_Y0.8111.00
128_A135_R0.8091.00
121_P124_F0.8041.00
150_I197_L0.8011.00
157_K163_E0.7971.00
163_E166_L0.7941.00
155_G165_Y0.7921.00
185_D188_F0.7901.00
96_L99_A0.7891.00
76_D82_L0.7841.00
84_K88_D0.7821.00
100_A107_L0.7791.00
4_I151_F0.7751.00
161_K164_E0.7711.00
128_A133_L0.7671.00
7_S208_R0.7661.00
26_G132_L0.7631.00
10_L19_S0.7621.00
104_K108_L0.7481.00
112_A115_N0.7461.00
126_K130_R0.7411.00
29_V37_L0.7381.00
2_I136_L0.7351.00
90_L199_L0.7341.00
6_E24_L0.7341.00
75_S80_R0.7321.00
96_L103_V0.7241.00
172_R176_Y0.7211.00
96_L100_A0.7211.00
185_D189_V0.7201.00
51_K55_E0.7191.00
117_D120_D0.7181.00
120_D123_Y0.7141.00
121_P125_Y0.7091.00
72_R75_S0.7081.00
129_L132_L0.7031.00
49_F54_V0.7021.00
74_L80_R0.7001.00
174_T177_D0.7001.00
38_E41_I0.6981.00
96_L105_K0.6981.00
62_S66_K0.6971.00
73_G76_D0.6971.00
50_G55_E0.6951.00
106_K109_D0.6941.00
184_E188_F0.6901.00
9_D22_F0.6891.00
97_I105_K0.6891.00
8_G19_S0.6811.00
98_F107_L0.6761.00
33_D94_D0.6681.00
89_L94_D0.6681.00
73_G80_R0.6671.00
64_I69_G0.6601.00
154_R161_K0.6541.00
205_G208_R0.6521.00
191_S194_S0.6491.00
37_L40_E0.6481.00
159_D165_Y0.6461.00
37_L42_R0.6461.00
99_A207_I0.6421.00
157_K160_R0.6401.00
28_I147_G0.6401.00
50_G53_E0.6391.00
49_F53_E0.6381.00
25_G99_A0.6351.00
6_E125_Y0.6331.00
29_V33_D0.6331.00
76_D81_R0.6301.00
83_L86_L0.6271.00
100_A108_L0.6251.00
157_K161_K0.6211.00
124_F128_A0.6211.00
197_L200_A0.6211.00
114_D118_P0.6201.00
113_L116_E0.6201.00
38_E194_S0.6191.00
152_D190_D0.6181.00
153_S166_L0.6161.00
106_K110_K0.6161.00
213_R216_K0.6151.00
126_K129_L0.6111.00
148_I151_F0.6041.00
25_G207_I0.6021.00
88_D92_K0.6011.00
52_D55_E0.6001.00
71_F75_S0.5961.00
183_I186_I0.5941.00
99_A102_I0.5911.00
132_L135_R0.5901.00
74_L81_R0.5891.00
129_L137_E0.5881.00
48_L51_K0.5871.00
63_K69_G0.5861.00
128_A137_E0.5861.00
9_D18_S0.5841.00
113_L118_P0.5841.00
86_L89_L0.5821.00
45_K198_Q0.5811.00
60_H205_G0.5801.00
4_I149_I0.5791.00
173_G177_D0.5741.00
171_L176_Y0.5721.00
64_I67_G0.5711.00
134_E137_E0.5691.00
130_R137_E0.5661.00
191_S197_L0.5631.00
73_G79_R0.5621.00
106_K111_Y0.5621.00
163_E167_R0.5601.00
125_Y132_L0.5581.00
90_L95_F0.5581.00
83_L91_A0.5571.00
36_E39_K0.5571.00
13_D17_P0.5561.00
44_L86_L0.5531.00
66_K69_G0.5501.00
139_F142_G0.5501.00
110_K114_D0.5481.00
128_A132_L0.5451.00
61_A209_R0.5441.00
153_S156_K0.5441.00
43_E46_R0.5421.00
112_A117_D0.5381.00
171_L175_R0.5361.00
125_Y136_L0.5341.00
67_G79_R0.5271.00
153_S161_K0.5241.00
113_L117_D0.5241.00
128_A136_L0.5231.00
72_R79_R0.5231.00
102_I108_L0.5221.00
86_L202_L0.5211.00
14_F17_P0.5211.00
102_I105_K0.5191.00
41_I199_L0.5191.00
133_L149_I0.5191.00
75_S81_R0.5181.00
33_D95_F0.5141.00
159_D166_L0.5141.00
11_G14_F0.5141.00
91_A95_F0.5121.00
112_A116_E0.5121.00
51_K54_V0.5101.00
153_S157_K0.5091.00
204_A208_R0.5051.00
155_G163_E0.5011.00
11_G19_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ekeA 2 0.8128 13.8 0.914 Contact Map
2d0bA 1 0.766 7.8 0.923 Contact Map
2etjA 1 0.6128 4.1 0.933 Contact Map
1e8pA 1 0.1106 3.8 0.934 Contact Map
2qwvA 2 0.2468 3.3 0.936 Contact Map
1io2A 1 0.7532 2.7 0.939 Contact Map
1xpnA 1 0.2596 2.5 0.94 Contact Map
4yd8A 1 0.1064 2.5 0.94 Contact Map
3qecA 3 0.2596 2.4 0.94 Contact Map
2a7oA 1 0.2213 2.4 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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