GREMLIN Database
ABC2_membrane_2 - ABC-2 family transporter protein
PFAM: PF12679 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 288 (274)
Sequences: 67010 (56040)
Seq/√Len: 3385.5
META: 0.834

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_A129_L4.0671.00
137_I141_G3.9511.00
115_S118_E3.7581.00
5_R9_R2.8421.00
6_K10_Q2.6771.00
237_S240_T2.4511.00
4_A125_L2.4451.00
222_G225_V2.3301.00
238_P241_Y2.2591.00
35_D38_G2.1631.00
3_I122_G2.1451.00
157_R160_S2.1111.00
277_A281_L2.0861.00
234_S237_S2.0751.00
234_S240_T2.0341.00
134_L137_I2.0321.00
170_L173_L2.0131.00
120_L279_A2.0001.00
168_A171_L1.9311.00
71_S74_L1.9101.00
262_W266_L1.8711.00
100_E123_K1.8371.00
7_E123_K1.8311.00
235_Y240_T1.8251.00
261_L264_S1.8231.00
78_P86_P1.8231.00
183_L278_L1.8121.00
158_G161_L1.7491.00
127_Y178_L1.7431.00
67_P70_F1.7221.00
71_S75_K1.7211.00
247_R251_L1.7181.00
267_A271_F1.7161.00
240_T243_L1.7101.00
49_F52_S1.7031.00
235_Y241_Y1.7001.00
47_A50_D1.6771.00
101_R106_L1.6471.00
190_S193_Q1.6191.00
117_L280_V1.6181.00
191_Q194_A1.6061.00
264_S267_A1.6001.00
34_L37_D1.5831.00
160_S163_L1.5561.00
243_L246_L1.5501.00
78_P82_A1.5401.00
109_L119_I1.5371.00
241_Y244_L1.5341.00
248_G252_G1.5221.00
237_S241_Y1.4941.00
64_L67_P1.4911.00
49_F53_L1.4591.00
78_P81_I1.4411.00
243_L247_R1.4361.00
244_L264_S1.4301.00
221_A224_Q1.4281.00
28_D32_A1.4281.00
209_L212_F1.4271.00
160_S164_L1.4221.00
167_L170_L1.4141.00
69_D72_R1.3911.00
29_L33_V1.3911.00
248_G251_L1.3861.00
231_Q234_S1.3851.00
242_F246_L1.3821.00
69_D73_D1.3781.00
268_L272_A1.3641.00
260_D263_P1.3621.00
32_A35_D1.3541.00
240_T244_L1.3501.00
117_L284_R1.3421.00
53_L57_S1.3161.00
215_P219_M1.3161.00
117_L121_L1.3091.00
118_E122_G1.3081.00
99_R103_R1.3021.00
137_I140_V1.2971.00
159_S163_L1.2971.00
264_S268_L1.2921.00
244_L248_G1.2891.00
265_L269_L1.2881.00
169_L172_L1.2791.00
52_S56_A1.2791.00
30_A34_L1.2771.00
28_D33_V1.2651.00
234_S238_P1.2581.00
150_L153_G1.2571.00
145_A149_L1.2531.00
271_F275_F1.2431.00
70_F74_L1.2331.00
221_A225_V1.2331.00
52_S55_F1.2201.00
66_I71_S1.2121.00
28_D31_L1.2021.00
220_P223_L1.1981.00
154_V157_R1.1921.00
51_A54_A1.1871.00
235_Y238_P1.1841.00
266_L270_A1.1821.00
68_E71_S1.1791.00
163_L167_L1.1741.00
124_L182_L1.1711.00
30_A33_V1.1691.00
153_G157_R1.1591.00
272_A276_L1.1571.00
193_Q197_L1.1551.00
31_L35_D1.1551.00
164_L168_A1.1531.00
219_M223_L1.1461.00
134_L138_L1.1441.00
37_D40_S1.1421.00
83_L86_P1.1401.00
48_A51_A1.1361.00
64_L68_E1.1291.00
138_L142_L1.1291.00
70_F76_V1.1231.00
148_L151_L1.1211.00
44_E47_A1.1191.00
151_L154_V1.1151.00
8_L133_I1.1121.00
66_I72_R1.1071.00
36_A39_S1.1071.00
65_D69_D1.1041.00
33_V36_A1.1031.00
206_A209_L1.0941.00
28_D56_A1.0931.00
82_A86_P1.0891.00
108_Q111_V1.0871.00
63_A66_I1.0821.00
138_L141_G1.0801.00
52_S58_G1.0791.00
47_A52_S1.0701.00
79_G82_A1.0691.00
50_D53_L1.0671.00
48_A52_S1.0661.00
47_A51_A1.0621.00
135_A139_L1.0621.00
22_L25_P1.0561.00
263_P267_A1.0561.00
134_L141_G1.0511.00
68_E72_R1.0481.00
233_L237_S1.0481.00
72_R75_K1.0441.00
192_Q196_Q1.0391.00
244_L247_R1.0371.00
4_A122_G1.0361.00
156_L160_S1.0331.00
200_F204_L1.0271.00
124_L179_A1.0231.00
191_Q195_A1.0221.00
66_I70_F1.0181.00
165_L168_A1.0161.00
187_L282_R1.0161.00
29_L32_A1.0151.00
207_I210_S1.0131.00
164_L171_L1.0101.00
239_L243_L1.0101.00
163_L170_L1.0091.00
11_L130_V1.0001.00
153_G156_L1.0001.00
8_L126_P1.0001.00
57_S60_A0.9991.00
216_I219_M0.9971.00
165_L169_L0.9951.00
39_S42_S0.9921.00
267_A270_A0.9911.00
193_Q196_Q0.9891.00
149_L153_G0.9861.00
9_R13_R0.9841.00
104_G107_E0.9831.00
65_D68_E0.9821.00
67_P71_S0.9821.00
54_A57_S0.9761.00
161_L164_L0.9711.00
42_S45_L0.9691.00
272_A275_F0.9681.00
45_L51_A0.9621.00
194_A197_L0.9621.00
248_G254_A0.9581.00
45_L49_F0.9571.00
62_S66_I0.9551.00
66_I69_D0.9511.00
149_L152_F0.9391.00
50_D54_A0.9361.00
209_L213_L0.9351.00
192_Q195_A0.9341.00
32_A37_D0.9321.00
28_D34_L0.9251.00
168_A172_L0.9241.00
201_L205_P0.9141.00
184_I188_A0.9131.00
21_L24_L0.9101.00
268_L271_F0.9101.00
42_S48_A0.9081.00
245_I248_G0.9051.00
46_V52_S0.9041.00
70_F75_K0.9031.00
46_V49_F0.9011.00
46_V50_D0.9001.00
99_R102_E0.8901.00
217_E220_P0.8901.00
234_S241_Y0.8891.00
114_V119_I0.8891.00
210_S214_F0.8871.00
41_L44_E0.8871.00
232_I235_Y0.8831.00
220_P224_Q0.8811.00
100_E105_T0.8811.00
56_A59_E0.8751.00
247_R250_L0.8721.00
219_M224_Q0.8711.00
35_D39_S0.8661.00
45_L48_A0.8651.00
278_L282_R0.8581.00
78_P88_I0.8571.00
54_A58_G0.8541.00
167_L172_L0.8531.00
67_P72_R0.8531.00
8_L12_L0.8511.00
150_L154_V0.8511.00
9_R12_L0.8511.00
80_L84_L0.8511.00
80_L83_L0.8511.00
260_D264_S0.8461.00
15_R19_I0.8451.00
249_I252_G0.8431.00
161_L165_L0.8421.00
49_F55_F0.8421.00
7_E10_Q0.8421.00
159_S162_L0.8401.00
270_A274_V0.8381.00
156_L159_S0.8311.00
95_L99_R0.8311.00
40_S44_E0.8291.00
38_G41_L0.8251.00
32_A36_A0.8241.00
43_R49_F0.8241.00
51_A57_S0.8221.00
180_L201_L0.8191.00
166_L170_L0.8181.00
251_L254_A0.8161.00
19_I23_L0.8141.00
121_L280_V0.8091.00
120_L280_V0.8081.00
154_V158_G0.8081.00
37_D41_L0.8071.00
28_D36_A0.8011.00
31_L34_L0.8011.00
242_F245_I0.7991.00
148_L152_F0.7961.00
53_L59_E0.7961.00
17_T21_L0.7931.00
264_S271_F0.7831.00
64_L70_F0.7811.00
29_L36_A0.7781.00
246_L249_I0.7781.00
79_G86_P0.7771.00
197_L200_F0.7751.00
167_L171_L0.7731.00
29_L35_D0.7701.00
210_S213_L0.7661.00
97_I185_S0.7611.00
122_G126_P0.7581.00
102_E191_Q0.7581.00
219_M222_G0.7571.00
237_S244_L0.7571.00
8_L129_L0.7561.00
30_A36_A0.7481.00
135_A138_L0.7481.00
162_L165_L0.7461.00
31_L37_D0.7451.00
35_D42_S0.7421.00
58_G62_S0.7351.00
166_L169_L0.7291.00
164_L167_L0.7271.00
147_A151_L0.7261.00
245_I249_I0.7231.00
259_A263_P0.7181.00
250_L253_G0.7151.00
248_G253_G0.7131.00
34_L39_S0.7081.00
269_L273_A0.7081.00
90_I93_T0.7051.00
190_S194_A0.7041.00
217_E221_A0.7031.00
48_A54_A0.7001.00
30_A35_D0.7001.00
49_F54_A0.6991.00
73_D76_V0.6961.00
33_V37_D0.6951.00
70_F73_D0.6911.00
28_D35_D0.6911.00
147_A150_L0.6861.00
151_L155_P0.6821.00
55_F58_G0.6791.00
101_R189_R0.6791.00
71_S76_V0.6771.00
160_S170_L0.6771.00
79_G83_L0.6751.00
155_P158_G0.6711.00
218_S222_G0.6711.00
54_A60_A0.6701.00
169_L173_L0.6691.00
82_A85_L0.6681.00
50_D55_F0.6671.00
59_E62_S0.6661.00
276_L280_V0.6641.00
12_L15_R0.6591.00
98_A101_R0.6551.00
110_L283_F0.6511.00
145_A148_L0.6511.00
281_L285_R0.6501.00
254_A258_L0.6491.00
86_P90_I0.6481.00
139_L143_L0.6431.00
30_A37_D0.6421.00
161_L168_A0.6421.00
49_F56_A0.6421.00
205_P209_L0.6401.00
211_G214_F0.6391.00
215_P218_S0.6391.00
246_L250_L0.6361.00
14_D17_T0.6361.00
33_V39_S0.6361.00
48_A53_L0.6331.00
63_A71_S0.6311.00
53_L56_A0.6281.00
163_L166_L0.6271.00
124_L128_L0.6261.00
77_V80_L0.6251.00
207_I213_L0.6211.00
16_R19_I0.6201.00
48_A55_F0.6171.00
183_L275_F0.6151.00
136_L140_V0.6141.00
146_L149_L0.6131.00
72_R76_V0.6131.00
69_D74_L0.6091.00
59_E63_A0.6091.00
274_V278_L0.6001.00
194_A198_A0.5981.00
64_L71_S0.5971.00
168_A173_L0.5961.00
238_P242_F0.5931.00
281_L284_R0.5931.00
233_L238_P0.5901.00
4_A126_P0.5841.00
44_E48_A0.5841.00
58_G64_L0.5811.00
58_G61_A0.5811.00
259_A262_W0.5801.00
218_S221_A0.5771.00
40_S46_V0.5761.00
206_A212_F0.5741.00
46_V51_A0.5681.00
86_P89_A0.5651.00
60_A63_A0.5651.00
179_A275_F0.5641.00
62_S65_D0.5621.00
42_S46_V0.5621.00
84_L88_I0.5611.00
199_L203_L0.5591.00
188_A197_L0.5551.00
249_I253_G0.5531.00
155_P159_S0.5521.00
206_A210_S0.5491.00
263_P266_L0.5471.00
40_S43_R0.5471.00
195_A198_A0.5461.00
68_E73_D0.5401.00
220_P225_V0.5391.00
241_Y245_I0.5391.00
35_D41_L0.5371.00
51_A58_G0.5351.00
38_G42_S0.5351.00
97_I186_T0.5331.00
35_D40_S0.5331.00
241_Y248_G0.5321.00
2_A5_R0.5321.00
15_R18_L0.5311.00
79_G88_I0.5301.00
165_L172_L0.5291.00
211_G215_P0.5271.00
216_I220_P0.5271.00
269_L272_A0.5251.00
262_W265_L0.5231.00
278_L281_L0.5231.00
114_V118_E0.5231.00
37_D42_S0.5221.00
64_L69_D0.5211.00
65_D72_R0.5201.00
280_V284_R0.5201.00
239_L242_F0.5191.00
164_L169_L0.5181.00
241_Y246_L0.5181.00
261_L268_L0.5181.00
266_L269_L0.5171.00
261_L265_L0.5151.00
89_A92_L0.5151.00
89_A93_T0.5131.00
55_F59_E0.5131.00
32_A38_G0.5121.00
159_S166_L0.5121.00
237_S248_G0.5101.00
65_D71_S0.5101.00
265_L268_L0.5091.00
134_L142_L0.5081.00
277_A280_V0.5071.00
232_I237_S0.5051.00
208_L211_G0.5031.00
31_L36_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pi7A 1 0.0139 12.8 0.922 Contact Map
2q67A 3 0.3368 6.4 0.932 Contact Map
2m20A 2 0.1111 4.1 0.938 Contact Map
1iijA 1 0.1215 3.9 0.939 Contact Map
3j2wE 1 0.1597 3.7 0.939 Contact Map
2l2tA 2 0.1354 3.6 0.939 Contact Map
2llmA 1 0.1493 3.1 0.942 Contact Map
2jwaA 2 0.1424 3.1 0.942 Contact Map
2wswA 3 0.5521 2.7 0.943 Contact Map
3wajA 1 0.8681 2.5 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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