GREMLIN Database
DUF3796 - Protein of unknown function (DUF3796)
PFAM: PF12676 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 120 (111)
Sequences: 570 (450)
Seq/√Len: 42.7
META: 0.821

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_G31_F3.1971.00
29_G32_G3.1731.00
10_G34_F2.9291.00
9_L12_L2.6461.00
57_N61_A2.6401.00
7_G10_G2.4531.00
13_G16_G2.4341.00
13_G34_F2.3831.00
7_G37_F2.1300.99
4_G40_F2.0250.99
35_G38_G2.0140.99
6_L9_L1.9500.99
4_G13_G1.9330.99
26_G29_G1.9170.99
10_G37_F1.7290.98
97_F101_I1.6470.97
28_F31_F1.4550.94
107_S111_Y1.4470.93
53_R63_L1.4260.93
66_F70_L1.4150.93
66_F107_S1.4120.93
65_A68_V1.4100.93
31_F101_I1.3650.91
20_F28_F1.3600.91
59_R63_L1.3410.90
104_F109_F1.3380.90
97_F104_F1.3310.90
25_P28_F1.3010.89
50_P58_V1.2860.89
98_A102_L1.2770.88
10_G13_G1.2670.88
3_L6_L1.2510.87
90_E98_A1.2500.87
33_F55_R1.2470.87
50_P54_F1.2310.86
12_L30_F1.2290.86
75_L80_L1.2110.85
10_G15_L1.1980.85
13_G31_F1.1930.84
105_A108_L1.1760.84
62_A67_F1.1630.83
14_F17_F1.1630.83
57_N60_K1.1450.82
108_L111_Y1.1440.82
33_F36_F1.1420.82
54_F58_V1.1340.81
100_L103_T1.0920.79
50_P55_R1.0890.79
59_R62_A1.0680.77
76_A95_L1.0680.77
108_L112_E1.0630.77
71_V75_L1.0610.77
52_E57_N1.0570.76
73_L103_T1.0510.76
79_I83_L1.0450.76
73_L77_L1.0260.74
6_L15_L1.0210.74
97_F108_L1.0140.73
99_V104_F1.0040.73
80_L85_N1.0030.73
103_T107_S1.0020.72
34_F37_F1.0020.72
30_F36_F0.9940.72
54_F69_G0.9920.72
39_Y49_I0.9890.71
60_K65_A0.9840.71
5_Y59_R0.9740.70
64_N68_V0.9640.69
49_I91_L0.9630.69
26_G32_G0.9600.69
13_G37_F0.9550.69
56_E60_K0.9460.68
101_I105_A0.9310.67
22_T32_G0.9290.67
59_R64_N0.9290.67
65_A75_L0.9280.67
109_F113_Y0.9270.66
30_F33_F0.9220.66
58_V71_V0.9210.66
89_L92_A0.9120.65
93_F98_A0.9010.64
61_A86_L0.8940.64
53_R110_L0.8650.61
10_G69_G0.8620.61
35_G39_Y0.8550.60
14_F32_G0.8530.60
79_I112_E0.8520.60
87_E90_E0.8490.60
52_E65_A0.8440.59
87_E91_L0.8350.58
21_V78_L0.8330.58
51_D65_A0.8270.58
27_F31_F0.8230.57
48_T54_F0.8080.56
97_F100_L0.8040.55
56_E83_L0.7920.54
50_P67_F0.7770.53
96_L99_V0.7740.53
98_A113_Y0.7710.52
89_L93_F0.7630.52
49_I54_F0.7620.51
54_F66_F0.7510.50
100_L109_F0.7420.50
69_G107_S0.7340.49
61_A65_A0.7230.48
93_F96_L0.7160.47
105_A109_F0.7140.47
94_A100_L0.7100.47
77_L80_L0.7030.46
91_L103_T0.6950.45
36_F79_I0.6910.45
32_G104_F0.6900.45
14_F21_V0.6850.44
97_F112_E0.6820.44
5_Y13_G0.6760.43
9_L75_L0.6740.43
14_F22_T0.6700.43
64_N107_S0.6690.43
29_G66_F0.6640.42
79_I84_G0.6610.42
53_R57_N0.6590.42
31_F34_F0.6540.41
55_R59_R0.6530.41
102_L105_A0.6490.41
39_Y56_E0.6290.39
4_G72_L0.6260.39
17_F56_E0.6160.38
98_A101_I0.6160.38
8_F16_G0.6020.37
12_L27_F0.6020.37
42_E46_S0.6000.36
77_L81_L0.5970.36
4_G7_G0.5960.36
39_Y42_E0.5950.36
79_I110_L0.5870.35
11_F77_L0.5860.35
19_T22_T0.5820.35
2_K55_R0.5810.35
107_S113_Y0.5750.34
83_L87_E0.5740.34
53_R83_L0.5730.34
36_F39_Y0.5720.34
12_L32_G0.5690.34
96_L103_T0.5660.34
80_L112_E0.5530.32
96_L113_Y0.5530.32
8_F14_F0.5500.32
88_A106_L0.5480.32
103_T112_E0.5460.32
6_L25_P0.5420.32
51_D57_N0.5400.31
52_E61_A0.5400.31
2_K75_L0.5390.31
82_L85_N0.5350.31
67_F72_L0.5300.31
54_F62_A0.5240.30
10_G25_P0.5240.30
51_D61_A0.5220.30
64_N103_T0.5220.30
102_L110_L0.5200.30
88_A92_A0.5190.30
94_A98_A0.5160.29
11_F31_F0.5150.29
80_L84_G0.5100.29
61_A64_N0.5050.29
60_K70_L0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aqpA 1 0.9583 3.7 0.93 Contact Map
3wdoA 1 0.5833 3.5 0.931 Contact Map
2cfqA 1 0.5917 2.2 0.938 Contact Map
3j1zP 8 0.6083 2.1 0.939 Contact Map
4pypA 1 0.525 1.8 0.94 Contact Map
4dx5A 3 0.9333 1.8 0.94 Contact Map
4k5yA 1 0.5583 1.8 0.94 Contact Map
3dl8G 1 0.8833 1.8 0.94 Contact Map
4oo9A 1 0.7667 1.8 0.941 Contact Map
3w9iA 3 0.9333 1.6 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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