GREMLIN Database
DUF3795 - Protein of unknown function (DUF3795)
PFAM: PF12675 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (82)
Sequences: 13175 (8213)
Seq/√Len: 907.0
META: 0.972

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_Y11_L2.6861.00
4_P63_A2.6041.00
4_P43_R2.3481.00
33_T36_D2.3201.00
70_F73_E2.2591.00
58_E81_K2.2031.00
22_E26_K2.0281.00
66_K76_E2.0061.00
69_E73_E2.0031.00
40_D48_R1.9011.00
18_E22_E1.8651.00
63_A68_V1.7121.00
24_W27_L1.7021.00
16_L19_K1.6671.00
20_T24_W1.5681.00
19_K22_E1.5661.00
28_F31_L1.5371.00
25_S31_L1.4371.00
68_V73_E1.4221.00
23_K27_L1.4171.00
2_I8_Y1.4151.00
19_K23_K1.3831.00
22_E25_S1.3381.00
43_R69_E1.3241.00
25_S29_G1.3231.00
23_K26_K1.3211.00
26_K29_G1.3101.00
17_R21_A1.3081.00
45_G49_K1.2441.00
16_L20_T1.2431.00
17_R38_N1.2161.00
51_G55_K1.1771.00
51_G54_R1.1711.00
40_D44_S1.1491.00
25_S30_A1.1321.00
32_I36_D1.1171.00
53_C56_D1.1151.00
24_W28_F1.1111.00
3_A7_L1.1071.00
40_D47_G1.1061.00
58_E61_K1.0911.00
60_R64_K1.0761.00
2_I10_G1.0671.00
39_C42_C1.0621.00
4_P64_K1.0371.00
27_L30_A1.0271.00
32_I37_I1.0111.00
77_F82_L1.0051.00
17_R20_T1.0021.00
2_I70_F0.9961.00
21_A24_W0.9961.00
43_R70_F0.9931.00
20_T28_F0.9821.00
50_F53_C0.9741.00
21_A25_S0.9681.00
24_W30_A0.9501.00
52_H55_K0.9471.00
16_L21_A0.9461.00
18_E21_A0.9371.00
68_V77_F0.9281.00
27_L31_L0.9141.00
61_K65_E0.8971.00
25_S28_F0.8841.00
20_T23_K0.8561.00
34_P37_I0.8261.00
18_E23_K0.8101.00
24_W29_G0.8021.00
22_E28_F0.7901.00
46_D49_K0.7831.00
40_D46_D0.7521.00
36_D51_G0.7401.00
40_D49_K0.7381.00
4_P60_R0.7341.00
26_K30_A0.7341.00
70_F77_F0.7331.00
56_D61_K0.7091.00
17_R24_W0.6971.00
20_T27_L0.6921.00
22_E30_A0.6911.00
50_F54_R0.6881.00
45_G48_R0.6721.00
13_P23_K0.6711.00
14_A37_I0.6651.00
16_L23_K0.6641.00
13_P20_T0.6621.00
19_K24_W0.6401.00
23_K28_F0.6391.00
49_K60_R0.6261.00
44_S53_C0.6251.00
26_K31_L0.6101.00
66_K75_D0.6061.00
32_I35_E0.6051.00
11_L14_A0.6031.00
68_V75_D0.6031.00
78_P81_K0.6031.00
75_D80_E0.6031.00
38_N50_F0.5981.00
47_G60_R0.5941.00
7_L59_I0.5771.00
22_E31_L0.5711.00
16_L31_L0.5651.00
33_T38_N0.5611.00
49_K53_C0.5611.00
49_K54_R0.5571.00
78_P83_K0.5491.00
10_G15_Y0.5491.00
3_A14_A0.5431.00
46_D50_F0.5371.00
70_F82_L0.5361.00
33_T37_I0.5351.00
80_E83_K0.5331.00
21_A26_K0.5321.00
17_R23_K0.5291.00
7_L11_L0.5291.00
28_F34_P0.5281.00
14_A24_W0.5221.00
14_A53_C0.5221.00
52_H56_D0.5201.00
68_V72_A0.5171.00
71_C74_C0.5091.00
63_A67_G0.5031.00
72_A77_F0.5021.00
11_L33_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ljoA 1 0.6386 3.3 0.897 Contact Map
2mcrA 1 0.1446 3.1 0.898 Contact Map
2fmaA 1 0.241 2.9 0.9 Contact Map
2b9dA 2 0.5542 2.1 0.907 Contact Map
2ewlA 1 0.5422 2 0.907 Contact Map
4kblA 2 0.8554 2 0.908 Contact Map
3t6pA 1 0.3976 1.7 0.911 Contact Map
4b7jA 3 0.3373 1.6 0.913 Contact Map
1ti6B 2 0.5904 1.5 0.914 Contact Map
2mvwA 2 0.4217 1.4 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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