GREMLIN Database
Zn_ribbon_2 - Putative zinc ribbon domain
PFAM: PF12674 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 82 (81)
Sequences: 6460 (4139)
Seq/√Len: 459.9
META: 0.919

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_D79_K4.7801.00
11_D14_D2.6551.00
39_S42_I2.5001.00
39_S50_F2.3971.00
33_Q38_T2.1971.00
54_K57_E2.1431.00
18_N24_S2.1001.00
7_M30_Y1.9671.00
18_N32_Y1.9231.00
63_T66_E1.9071.00
42_I50_F1.8081.00
64_E68_R1.7221.00
44_M75_L1.6851.00
18_N22_S1.6681.00
9_L15_G1.6631.00
10_K14_D1.6581.00
43_T46_E1.6081.00
14_D29_S1.6001.00
12_D15_G1.4081.00
44_M48_I1.4061.00
46_E49_E1.3471.00
19_A36_K1.3291.00
50_F54_K1.3061.00
52_V56_K1.3061.00
70_M74_F1.2961.00
3_Q26_D1.2571.00
29_S33_Q1.2351.00
65_E69_A1.2291.00
45_E48_I1.2211.00
52_V68_R1.2151.00
4_S80_R1.1911.00
69_A73_R1.1751.00
12_D23_K1.1741.00
42_I46_E1.1501.00
68_R72_T1.1181.00
66_E69_A1.1141.00
70_M73_R1.1021.00
49_E68_R1.0971.00
20_D24_S1.0771.00
47_M51_C1.0651.00
38_T43_T1.0521.00
51_C71_M1.0471.00
15_G25_E1.0391.00
59_G62_M1.0341.00
49_E53_P1.0321.00
74_F77_K1.0181.00
71_M75_L0.9801.00
77_K82_K0.9421.00
69_A72_T0.9251.00
53_P64_E0.9161.00
56_K64_E0.8991.00
2_C5_C0.8911.00
44_M72_T0.8861.00
55_M58_M0.8821.00
44_M76_P0.8591.00
28_C31_C0.8501.00
53_P56_K0.8331.00
54_K58_M0.8301.00
55_M59_G0.7991.00
27_Y37_F0.7951.00
51_C54_K0.7941.00
16_G19_A0.7881.00
48_I72_T0.7851.00
17_T33_Q0.7791.00
15_G29_S0.7661.00
17_T23_K0.7611.00
11_D15_G0.7571.00
42_I47_M0.7481.00
45_E49_E0.7331.00
13_E23_K0.7321.00
44_M71_M0.7271.00
52_V72_T0.7231.00
64_E67_A0.7091.00
73_R77_K0.6871.00
40_P47_M0.6681.00
36_K41_D0.6581.00
4_S37_F0.6531.00
50_F53_P0.6521.00
56_K60_K0.6521.00
66_E70_M0.6501.00
36_K40_P0.6491.00
51_C75_L0.6421.00
51_C55_M0.6370.99
48_I76_P0.6300.99
62_M70_M0.6280.99
60_K67_A0.6230.99
37_F78_L0.6220.99
40_P43_T0.6210.99
11_D29_S0.6130.99
79_K82_K0.6130.99
48_I52_V0.6100.99
56_K67_A0.6090.99
45_E72_T0.6070.99
1_F74_F0.6050.99
47_M55_M0.6030.99
16_G24_S0.6030.99
13_E29_S0.5970.99
38_T42_I0.5970.99
6_G74_F0.5970.99
37_F80_R0.5930.99
48_I68_R0.5900.99
16_G35_G0.5880.99
68_R71_M0.5870.99
15_G23_K0.5810.99
52_V64_E0.5720.99
44_M47_M0.5700.99
47_M50_F0.5690.99
55_M71_M0.5680.99
40_P76_P0.5620.99
53_P58_M0.5420.98
62_M67_A0.5340.98
67_A74_F0.5310.98
42_I54_K0.5290.98
56_K65_E0.5290.98
56_K59_G0.5250.98
48_I75_L0.5230.98
71_M74_F0.5200.98
52_V69_A0.5150.98
67_A71_M0.5130.98
11_D23_K0.5120.98
3_Q32_Y0.5060.97
16_G23_K0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qqcA 1 0.8659 55.9 0.857 Contact Map
2pv0B 1 0.9512 48 0.864 Contact Map
2jtnA 1 0.4146 47.9 0.864 Contact Map
2co8A 1 0.4756 42.1 0.869 Contact Map
4u7tA 2 0.8902 40.3 0.87 Contact Map
2lzuA 1 0.4756 37.6 0.872 Contact Map
2fc7A 1 0.7195 34.5 0.874 Contact Map
4glxA 1 0.9024 32.7 0.876 Contact Map
2xqnT 1 0.378 30.1 0.878 Contact Map
3h2yA 1 0.4756 29.7 0.879 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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