GREMLIN Database
DUF3794 - Domain of unknown function (DUF3794)
PFAM: PF12673 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (74)
Sequences: 6596 (5355)
Seq/√Len: 622.5
META: 0.848

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_K51_F3.1881.00
28_G48_F2.6871.00
29_E45_E2.4951.00
8_V74_V2.1331.00
33_Q41_S2.0581.00
10_G72_I2.0191.00
20_I23_K1.9651.00
54_I57_A1.9351.00
15_T29_E1.8991.00
13_R31_E1.8791.00
20_I25_I1.8591.00
32_V46_I1.8111.00
31_E45_E1.7591.00
16_E27_E1.6921.00
33_Q43_E1.6311.00
34_I44_G1.5951.00
58_E61_M1.5731.00
22_D56_G1.5151.00
29_E47_P1.4161.00
12_V67_A1.4151.00
25_I49_S1.4041.00
22_D55_P1.3961.00
24_V63_V1.3561.00
10_G30_L1.3211.00
5_I34_I1.2621.00
17_V65_V1.2511.00
27_E49_S1.2451.00
25_I51_F1.2261.00
21_E58_E1.2141.00
24_V57_A1.2061.00
32_V44_G1.1841.00
23_K53_E1.1701.00
17_V63_V1.1571.00
26_V50_Q1.1341.00
21_E59_E1.1221.00
36_Y40_H1.1221.00
31_E43_E1.1021.00
19_V57_A1.0811.00
34_I42_L1.0781.00
57_A61_M1.0361.00
28_G47_P1.0321.00
20_I51_F1.0081.00
19_V63_V0.9671.00
10_G69_V0.9591.00
6_L39_V0.9291.00
18_K25_I0.9211.00
50_Q53_E0.9151.00
71_D74_V0.9131.00
13_R29_E0.8991.00
12_V69_V0.8951.00
18_K59_E0.8771.00
9_D33_Q0.8641.00
12_V48_F0.8461.00
11_K31_E0.8441.00
8_V34_I0.8341.00
64_D67_A0.8271.00
17_V26_V0.7761.00
19_V24_V0.7691.00
63_V67_A0.7541.00
24_V54_I0.7531.00
41_S44_G0.7471.00
22_D54_I0.7431.00
26_V65_V0.7331.00
14_I67_A0.7311.00
57_A63_V0.7281.00
35_L41_S0.7281.00
18_K27_E0.7011.00
49_S53_E0.6971.00
3_E37_G0.6951.00
3_E7_K0.6881.00
38_P41_S0.6811.00
67_A70_E0.6661.00
7_K51_F0.6611.00
17_V24_V0.6531.00
14_I29_E0.6461.00
44_G47_P0.6451.00
22_D53_E0.6411.00
40_H44_G0.6321.00
42_L74_V0.6221.00
14_I17_V0.6131.00
13_R45_E0.6131.00
3_E38_P0.6051.00
19_V61_M0.6021.00
59_E62_I0.6011.00
34_I54_I0.5881.00
8_V12_V0.5871.00
6_L32_V0.5811.00
26_V52_I0.5801.00
32_V35_L0.5711.00
38_P43_E0.5671.00
56_G59_E0.5641.00
47_P50_Q0.5641.00
12_V30_L0.5631.00
10_G32_V0.5601.00
4_K33_Q0.5571.00
4_K15_T0.5531.00
36_Y70_E0.5531.00
6_L9_D0.5521.00
64_D68_E0.5481.00
10_G28_G0.5471.00
19_V33_Q0.5460.99
69_V72_I0.5460.99
22_D57_A0.5370.99
6_L35_L0.5270.99
24_V52_I0.5200.99
3_E51_F0.5190.99
42_L73_D0.5110.99
20_I59_E0.5080.99
34_I39_V0.5030.99
26_V67_A0.5010.99
9_D64_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vv1A 2 0.5584 2.8 0.869 Contact Map
3m9dG 1 0.1299 2.5 0.873 Contact Map
4un4B 1 0.6623 2.5 0.873 Contact Map
3m91B 1 0.1299 2.4 0.874 Contact Map
4qq0A 1 0.987 2.4 0.874 Contact Map
1b77A 3 0.8571 2.2 0.877 Contact Map
4m0nA 1 0.3896 1.9 0.881 Contact Map
1usuB 1 0.8961 1.8 0.882 Contact Map
3nv1A 1 0.4675 1.8 0.883 Contact Map
4alzA 1 0.7403 1.7 0.884 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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