GREMLIN Database
DUF3793 - Protein of unknown function (DUF3793)
PFAM: PF12672 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 166 (165)
Sequences: 1946 (1705)
Seq/√Len: 132.7
META: 0.721

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_F109_L4.0761.00
14_P61_D3.1781.00
135_E139_K2.8431.00
39_I89_K2.8121.00
123_C126_C2.8031.00
134_D137_E2.7761.00
37_R55_P2.7511.00
114_G133_G2.7481.00
118_N122_N2.5911.00
8_T16_N2.3051.00
155_L160_K2.2871.00
124_K135_E2.2661.00
74_Y116_I2.2211.00
125_C135_E2.1961.00
103_L109_L2.1541.00
15_A51_Y2.0701.00
32_N37_R2.0701.00
84_C104_F2.0181.00
14_P106_G2.0001.00
110_E133_G1.9971.00
113_K117_E1.9831.00
2_I156_L1.9561.00
125_C139_K1.9521.00
137_E140_K1.8451.00
88_L104_F1.8121.00
92_L101_I1.7711.00
141_L145_Y1.7431.00
66_E113_K1.7391.00
87_R91_R1.7241.00
70_F103_L1.6981.00
10_A152_Y1.6781.00
55_P59_E1.6711.00
114_G118_N1.6421.00
87_R90_R1.6341.00
67_V70_F1.5981.00
19_S49_L1.5651.00
150_E154_R1.5461.00
61_D103_L1.5341.00
141_L144_R1.4931.00
161_S164_Q1.4921.00
138_A141_L1.4591.00
3_R153_C1.4391.00
127_G142_F1.4291.00
49_L92_L1.4161.00
74_Y87_R1.4051.00
160_K164_Q1.4011.00
147_K151_I1.3971.00
19_S47_R1.3951.00
110_E138_A1.3881.00
131_V142_F1.3851.00
128_Y146_D1.3731.00
39_I86_A1.3391.00
71_L104_F1.3301.00
80_S83_E1.3221.00
24_L28_N1.3151.00
124_K133_G1.3131.00
73_E113_K1.3091.00
92_L97_F1.2951.00
27_L31_L1.2731.00
70_F116_I1.2501.00
38_L52_V1.2421.00
70_F74_Y1.2401.00
43_E48_A1.2251.00
40_P48_A1.2201.00
27_L38_L1.2031.00
137_E141_L1.1980.99
61_D67_V1.1930.99
116_I120_G1.1730.99
152_Y165_L1.1530.99
68_R72_K1.1440.99
39_I85_L1.1320.99
143_E147_K1.1210.99
12_I145_Y1.1180.99
17_L49_L1.1140.99
36_L54_R1.1140.99
28_N32_N1.1090.99
125_C128_Y1.1060.99
55_P82_E1.0980.99
148_C152_Y1.0900.99
85_L89_K1.0740.99
67_V109_L1.0640.99
125_C138_A1.0630.99
10_A148_C1.0530.99
36_L52_V1.0520.99
133_G138_A1.0440.99
151_I155_L1.0380.99
17_L101_I1.0360.99
155_L158_Q1.0190.98
62_L84_C1.0110.98
103_L112_V1.0010.98
120_G123_C0.9750.98
57_L60_R0.9650.98
41_L85_L0.9420.97
69_E113_K0.9220.97
17_L41_L0.9100.97
24_L27_L0.9030.96
12_I144_R0.8900.96
18_F38_L0.8810.96
39_I82_E0.8810.96
17_L107_Y0.8770.96
18_F52_V0.8770.96
124_K131_V0.8740.96
134_D138_A0.8680.96
124_K134_D0.8670.96
61_D109_L0.8650.95
154_R157_A0.8630.95
74_Y106_G0.8530.95
88_L101_I0.8450.95
49_L97_F0.8290.94
59_E63_S0.8230.94
154_R158_Q0.8000.93
42_R49_L0.7970.93
64_D67_V0.7880.93
54_R165_L0.7860.93
97_F107_Y0.7780.92
146_D149_R0.7770.92
143_E146_D0.7760.92
40_P43_E0.7740.92
120_G126_C0.7620.91
14_P57_L0.7480.91
103_L113_K0.7470.91
51_Y104_F0.7460.90
31_L38_L0.7450.90
149_R153_C0.7430.90
84_C87_R0.7370.90
131_V138_A0.7370.90
128_Y131_V0.7340.90
35_G54_R0.7320.90
27_L50_I0.7200.89
76_Y104_F0.7170.89
44_S47_R0.7100.88
119_K123_C0.7070.88
24_L40_P0.7070.88
116_I119_K0.7070.88
63_S94_E0.7050.88
24_L30_L0.7000.87
114_G131_V0.6940.87
28_N40_P0.6930.87
110_E137_E0.6890.87
140_K147_K0.6870.86
27_L162_L0.6870.86
139_K143_E0.6870.86
5_C107_Y0.6870.86
128_Y145_Y0.6810.86
19_S50_I0.6800.86
49_L101_I0.6760.86
127_G159_G0.6750.86
124_K138_A0.6740.85
59_E80_S0.6680.85
39_I53_Y0.6660.85
77_E83_E0.6640.85
30_L163_E0.6620.84
99_H130_K0.6580.84
26_E30_L0.6570.84
117_E120_G0.6480.83
16_N107_Y0.6450.83
116_I142_F0.6440.83
4_H19_S0.6430.83
97_F130_K0.6430.83
109_L113_K0.6410.82
101_I124_K0.6400.82
58_L81_L0.6380.82
58_L85_L0.6360.82
146_D150_E0.6360.82
77_E80_S0.6340.82
89_K93_R0.6340.82
41_L88_L0.6320.82
2_I6_A0.6310.81
15_A106_G0.6290.81
29_R56_E0.6290.81
83_E87_R0.6270.81
68_R77_E0.6210.80
18_F24_L0.6200.80
8_T13_K0.6170.80
28_N37_R0.6170.80
12_I139_K0.6170.80
130_K142_F0.6150.80
37_R53_Y0.6100.79
4_H16_N0.6100.79
47_R97_F0.6070.79
3_R18_F0.6040.79
3_R149_R0.5980.78
131_V141_L0.5950.78
72_K78_D0.5950.78
151_I154_R0.5940.77
92_L96_G0.5930.77
16_N97_F0.5930.77
53_Y85_L0.5890.77
98_P127_G0.5870.77
72_K77_E0.5840.76
8_T51_Y0.5830.76
127_G148_C0.5830.76
114_G141_L0.5820.76
56_E60_R0.5820.76
8_T152_Y0.5810.76
59_E81_L0.5800.76
4_H18_F0.5790.76
7_P12_I0.5750.75
140_K143_E0.5750.75
2_I153_C0.5750.75
53_Y82_E0.5690.74
2_I152_Y0.5670.74
126_C130_K0.5670.74
20_L110_E0.5670.74
4_H148_C0.5640.74
62_L67_V0.5640.74
126_C141_L0.5630.74
123_C130_K0.5580.73
66_E109_L0.5560.73
117_E121_K0.5560.73
86_A89_K0.5550.73
41_L91_R0.5540.72
83_E96_G0.5530.72
32_N39_I0.5510.72
14_P51_Y0.5480.72
160_K165_L0.5440.71
18_F50_I0.5430.71
3_R51_Y0.5430.71
71_L115_F0.5430.71
78_D84_C0.5420.71
25_R31_L0.5380.70
22_K46_G0.5370.70
25_R72_K0.5350.70
74_Y91_R0.5340.70
144_R152_Y0.5340.70
38_L50_I0.5340.70
128_Y149_R0.5330.70
18_F48_A0.5320.69
27_L107_Y0.5320.69
114_G120_G0.5310.69
151_I165_L0.5300.69
3_R6_A0.5300.69
71_L88_L0.5300.69
44_S80_S0.5230.68
147_K150_E0.5180.67
12_I148_C0.5180.67
49_L115_F0.5170.67
50_I88_L0.5170.67
45_E94_E0.5160.67
68_R79_G0.5150.67
57_L164_Q0.5140.67
11_G156_L0.5130.67
78_D83_E0.5090.66
119_K122_N0.5070.66
2_I105_L0.5060.66
158_Q164_Q0.5050.65
60_R63_S0.5030.65
69_E73_E0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3t6aA 2 0.8012 23.9 0.944 Contact Map
3w4rA 1 0.9578 19.1 0.947 Contact Map
3rdwA 1 0.5904 19 0.947 Contact Map
1s3cA 2 0.7289 17 0.948 Contact Map
2mu0A 1 0.6506 15.5 0.949 Contact Map
3cz8A 2 0.9096 15.2 0.949 Contact Map
1z2zA 1 0.8916 13.9 0.95 Contact Map
4q5yA 2 0.3795 13.7 0.95 Contact Map
3f0iA 1 0.6145 13.5 0.95 Contact Map
4b9wA 2 0.4518 11.8 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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