GREMLIN Database
DUF3792 - Protein of unknown function (DUF3792)
PFAM: PF12670 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 115 (113)
Sequences: 3548 (3023)
Seq/√Len: 284.3
META: 0.802

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_L44_I3.4421.00
12_A52_G3.2541.00
11_I55_I2.4581.00
52_G71_V2.4571.00
69_L105_L2.4361.00
39_I43_I2.4041.00
65_W113_I2.2931.00
46_I107_A2.2251.00
56_A71_V2.1761.00
64_G115_G2.0991.00
16_T75_Y2.0931.00
60_A67_H2.0061.00
76_F104_C1.9881.00
76_F101_L1.9801.00
64_G68_G1.9791.00
53_G57_G1.9771.00
107_A111_G1.8831.00
64_G112_G1.8221.00
8_G56_A1.8171.00
9_L74_L1.7121.00
49_I53_G1.5841.00
36_V39_I1.5591.00
16_T48_S1.5531.00
8_G12_A1.5471.00
26_L32_L1.5281.00
68_G108_G1.5121.00
3_K7_K1.4981.00
43_I47_L1.4841.00
9_L13_L1.4681.00
23_L40_V1.4651.00
104_C108_G1.4651.00
99_I103_L1.4591.00
25_L29_F1.4431.00
26_L30_T1.4361.00
69_L109_A1.4261.00
108_G112_G1.4181.00
46_I50_F1.3491.00
11_I51_I1.2991.00
19_L23_L1.2451.00
55_I59_K1.2211.00
53_G71_V1.1991.00
8_G52_G1.1941.00
49_I104_C1.1751.00
102_L106_L1.1591.00
111_G115_G1.1291.00
5_I71_V1.1261.00
12_A48_S1.1061.00
45_T75_Y1.1051.00
54_F114_L1.1001.00
45_T104_C1.0831.00
23_L37_L1.0811.00
15_I48_S1.0811.00
49_I108_G1.0741.00
46_I103_L1.0631.00
64_G109_A1.0541.00
98_L102_L1.0481.00
57_G60_A1.0381.00
9_L71_V1.0321.00
99_I102_L1.0281.00
72_G104_C1.0061.00
103_L107_A0.9891.00
53_G111_G0.9851.00
41_I45_T0.9731.00
65_W109_A0.9661.00
26_L68_G0.9631.00
73_L105_L0.9631.00
52_G56_A0.9331.00
51_I55_I0.9191.00
30_T34_E0.9121.00
63_K67_H0.9111.00
50_F54_F0.8891.00
37_L41_I0.8671.00
93_F97_L0.8641.00
7_K59_K0.8541.00
84_L87_Y0.8381.00
42_I100_K0.8231.00
8_G55_I0.8161.00
12_A16_T0.8151.00
68_G72_G0.8120.99
57_G111_G0.8070.99
100_K115_G0.8010.99
3_K6_L0.8000.99
54_F58_K0.7890.99
95_L98_L0.7810.99
65_W69_L0.7780.99
20_L41_I0.7770.99
80_L84_L0.7760.99
94_S97_L0.7700.99
25_L115_G0.7690.99
49_I75_Y0.7620.99
56_A67_H0.7620.99
27_L34_E0.7580.99
48_S52_G0.7460.99
13_L17_L0.7430.99
4_A60_A0.7390.99
16_T42_I0.7350.99
5_I9_L0.7340.99
72_G108_G0.7300.99
67_H70_L0.7190.99
8_G48_S0.7160.99
8_G71_V0.7150.99
105_L109_A0.7140.99
41_I83_S0.7020.99
50_F97_L0.6900.98
20_L52_G0.6880.98
44_I48_S0.6880.98
4_A8_G0.6610.98
15_I102_L0.6560.98
24_A45_T0.6540.98
101_L105_L0.6520.98
39_I84_L0.6510.98
61_G64_G0.6480.98
110_L114_L0.6460.97
66_L77_L0.6430.97
75_Y79_L0.6430.97
57_G68_G0.6380.97
73_L77_L0.6370.97
15_I19_L0.6300.97
76_F100_K0.6260.97
45_T76_F0.6220.97
40_V54_F0.6210.97
82_I86_F0.6190.97
12_A20_L0.6140.97
9_L17_L0.6140.97
12_A71_V0.6140.97
56_A60_A0.6120.96
65_W115_G0.6110.96
101_L104_C0.6090.96
53_G59_K0.6090.96
97_L101_L0.6090.96
22_I26_L0.6080.96
4_A56_A0.6080.96
30_T69_L0.6050.96
96_S100_K0.6040.96
21_L24_A0.6030.96
41_I100_K0.6030.96
24_A28_Y0.6020.96
15_I51_I0.6010.96
23_L27_L0.5970.96
53_G67_H0.5970.96
5_I8_G0.5910.96
81_L85_L0.5900.96
55_I80_L0.5730.95
37_L54_F0.5710.95
88_D91_F0.5700.95
79_L83_S0.5680.95
20_L66_L0.5680.95
65_W107_A0.5590.94
6_L18_I0.5590.94
41_I44_I0.5580.94
9_L67_H0.5500.94
75_Y104_C0.5460.94
5_I67_H0.5430.93
41_I67_H0.5430.93
4_A59_K0.5360.93
45_T72_G0.5340.93
58_K61_G0.5330.93
42_I76_F0.5240.92
50_F114_L0.5230.92
36_V40_V0.5220.92
69_L73_L0.5220.92
20_L24_A0.5210.92
72_G76_F0.5200.92
28_Y31_S0.5180.92
27_L31_S0.5160.91
28_Y103_L0.5140.91
33_S46_I0.5140.91
9_L111_G0.5130.91
94_S114_L0.5100.91
14_I22_I0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev6A 3 0.5652 39.2 0.806 Contact Map
4i0uA 4 0.5478 33.9 0.812 Contact Map
2cfqA 1 1 7.5 0.861 Contact Map
4q2eA 2 0.9478 6.9 0.864 Contact Map
4pypA 1 0.9739 6.2 0.867 Contact Map
4m5bA 1 0.7043 5.7 0.869 Contact Map
3dh4A 3 0.9217 5.5 0.87 Contact Map
3pjzA 2 0.9565 4.3 0.876 Contact Map
4m64A 1 0.9043 4.3 0.877 Contact Map
3wdoA 1 0.887 4 0.878 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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