GREMLIN Database
DUF3791 - Protein of unknown function (DUF3791)
PFAM: PF12668 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (58)
Sequences: 6998 (3774)
Seq/√Len: 495.5
META: 0.959

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_K54_D3.7251.00
29_G32_D2.8071.00
37_C40_A2.0211.00
9_E46_D1.9691.00
44_Q48_Y1.8721.00
17_S20_E1.7211.00
3_L35_I1.7151.00
16_L21_A1.7071.00
23_R27_K1.6841.00
16_L20_E1.6041.00
8_E18_G1.5721.00
16_L24_L1.5491.00
40_A43_T1.5151.00
9_E12_E1.4611.00
13_R54_D1.4541.00
19_K23_R1.3661.00
45_G48_Y1.3541.00
46_D49_I1.3201.00
30_I56_Y1.3021.00
22_Y26_K1.2851.00
13_R47_E1.2461.00
10_Y14_K1.2211.00
32_D36_E1.2211.00
55_E58_K1.2161.00
22_Y31_L1.1901.00
49_I52_D1.1351.00
38_Y42_H1.1221.00
9_E50_V1.1151.00
20_E23_R1.1141.00
33_Y41_L1.0721.00
20_E24_L1.0271.00
54_D58_K1.0041.00
10_Y53_I1.0021.00
40_A44_Q0.9751.00
28_Y57_I0.9671.00
5_F9_E0.9321.00
56_Y59_N0.9271.00
6_C34_I0.9181.00
30_I57_I0.9131.00
34_I41_L0.9121.00
10_Y54_D0.8991.00
25_L31_L0.8871.00
2_F49_I0.8631.00
13_R50_V0.8441.00
11_A18_G0.8251.00
3_L31_L0.8071.00
31_L35_I0.8041.00
33_Y52_D0.7821.00
51_E55_E0.7621.00
37_C43_T0.7591.00
2_F41_L0.7391.00
44_Q49_I0.7351.00
41_L52_D0.7231.00
13_R51_E0.7191.00
47_E51_E0.7161.00
7_I22_Y0.7131.00
24_L57_I0.6811.00
21_A25_L0.6791.00
2_F8_E0.6781.00
2_F5_F0.6751.00
41_L49_I0.6741.00
25_L30_I0.6701.00
7_I31_L0.6671.00
48_Y51_E0.6661.00
30_I53_I0.6361.00
55_E59_N0.6351.00
23_R26_K0.6281.00
5_F46_D0.6211.00
24_L30_I0.6171.00
6_C41_L0.6020.99
26_K31_L0.5920.99
8_E11_A0.5920.99
4_V8_E0.5650.99
38_Y43_T0.5610.99
34_I43_T0.5380.99
39_D43_T0.5350.99
33_Y56_Y0.5320.99
24_L28_Y0.5310.99
42_H45_G0.5240.98
10_Y24_L0.5170.98
10_Y25_L0.5160.98
6_C49_I0.5140.98
52_D55_E0.5130.98
5_F8_E0.5120.98
24_L27_K0.5120.98
45_G49_I0.5020.98
33_Y37_C0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i5qB 4 0.9833 20.6 0.813 Contact Map
3i5pA 1 0.9833 16.9 0.82 Contact Map
4jzaA 2 1 12.5 0.83 Contact Map
4u9bA 1 0.9833 10.3 0.836 Contact Map
3al0B 1 1 8.3 0.843 Contact Map
3ip4B 1 1 7.8 0.845 Contact Map
3j7aZ 1 0.5833 7 0.849 Contact Map
1yx3A 1 0.8667 6.7 0.849 Contact Map
3k1tA 2 0.8833 6.7 0.849 Contact Map
3h0lB 1 1 6.5 0.851 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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