GREMLIN Database
PrgI - PrgI family protein
PFAM: PF12666 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 90 (86)
Sequences: 10161 (7486)
Seq/√Len: 807.2
META: 0.918

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_F37_F3.0801.00
49_L53_L2.8981.00
53_L57_P2.6091.00
47_A51_A2.4511.00
69_R73_K2.4261.00
78_F82_L2.2311.00
28_G58_F2.1571.00
76_L80_R2.1281.00
10_E20_R2.0841.00
20_R72_E2.0461.00
81_F86_K1.9461.00
69_R77_A1.7511.00
24_Y72_E1.7021.00
23_I27_G1.6991.00
40_P43_L1.6941.00
60_A71_L1.6471.00
50_L53_L1.6291.00
73_K76_L1.6071.00
60_A64_Y1.4911.00
51_A55_A1.4691.00
32_G55_A1.4421.00
14_F22_F1.4401.00
73_K77_A1.3601.00
80_R84_R1.3331.00
5_D8_E1.3321.00
13_I22_F1.3231.00
74_W78_F1.2991.00
22_F26_A1.2881.00
35_L54_V1.2841.00
84_R87_K1.2701.00
32_G35_L1.2591.00
50_L54_V1.2201.00
70_P73_K1.2011.00
39_L43_L1.1911.00
52_I56_L1.1851.00
74_W77_A1.1581.00
47_A53_L1.1441.00
24_Y28_G1.1121.00
59_A63_F1.0741.00
35_L39_L1.0721.00
82_L86_K1.0681.00
48_A52_I1.0461.00
79_I83_L1.0461.00
18_T21_Q1.0351.00
52_I55_A1.0301.00
48_A51_A1.0201.00
2_V5_D1.0171.00
58_F61_L0.9841.00
58_F62_A0.9731.00
51_A54_V0.9421.00
66_I74_W0.9391.00
29_A33_F0.9251.00
40_P47_A0.9241.00
47_A57_P0.9231.00
37_F40_P0.9041.00
32_G51_A0.8961.00
13_I19_L0.8781.00
54_V58_F0.8421.00
28_G32_G0.8391.00
54_V57_P0.8171.00
72_E76_L0.8101.00
37_F41_P0.8071.00
32_G58_F0.8061.00
47_A50_L0.8011.00
46_L50_L0.7991.00
77_A81_F0.7911.00
7_T11_D0.7891.00
17_L63_F0.7791.00
82_L85_P0.7781.00
69_R74_W0.7781.00
10_E18_T0.7731.00
49_L52_I0.7701.00
2_V9_V0.7421.00
78_F81_F0.7381.00
8_E12_K0.7361.00
35_L40_P0.7231.00
75_L78_F0.7091.00
48_A54_V0.6991.00
3_P13_I0.6971.00
19_L23_I0.6931.00
83_L86_K0.6901.00
10_E65_K0.6771.00
57_P60_A0.6751.00
34_L37_F0.6751.00
48_A56_L0.6711.00
43_L46_L0.6701.00
18_T22_F0.6691.00
59_A62_A0.6641.00
24_Y61_L0.6591.00
71_L76_L0.6441.00
65_K68_G0.6381.00
6_I11_D0.6361.00
56_L59_A0.6341.00
3_P6_I0.6331.00
11_D19_L0.6271.00
72_E77_A0.6241.00
50_L57_P0.6231.00
31_I35_L0.6221.00
36_Y40_P0.6141.00
23_I30_G0.6101.00
25_L28_G0.6071.00
33_F36_Y0.6041.00
57_P61_L0.6011.00
6_I9_V0.6001.00
38_L41_P0.5971.00
24_Y62_A0.5941.00
53_L56_L0.5811.00
5_D88_R0.5791.00
47_A58_F0.5791.00
8_E11_D0.5701.00
39_L42_F0.5661.00
49_L57_P0.5611.00
31_I34_L0.5591.00
17_L25_L0.5521.00
83_L87_K0.5491.00
61_L64_Y0.5491.00
46_L53_L0.5421.00
41_P47_A0.5401.00
47_A54_V0.5381.00
12_K18_T0.5321.00
27_G30_G0.5251.00
26_A30_G0.5251.00
32_G36_Y0.5241.00
61_L71_L0.5171.00
3_P12_K0.5151.00
55_A59_A0.5141.00
64_Y71_L0.5111.00
65_K70_P0.5091.00
29_A32_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j01B 1 0.8111 10.1 0.865 Contact Map
1pp0A 1 0.4556 4.7 0.884 Contact Map
4qtnA 3 0.8889 4.4 0.886 Contact Map
4qncA 2 0.7333 3.5 0.891 Contact Map
4qndA 2 0.7778 3.3 0.892 Contact Map
4b03D 5 0.5778 3 0.894 Contact Map
2lzpA 1 0.3444 2.8 0.896 Contact Map
3ux2A 2 0.3333 2.8 0.896 Contact Map
2xa0A 1 0.2333 2.8 0.897 Contact Map
4u9nA 2 0.9222 2.4 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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