GREMLIN Database
G-patch_2 - DExH-box splicing factor binding site
PFAM: PF12656 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (73)
Sequences: 958 (736)
Seq/√Len: 86.2
META: 0.354

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_A39_G3.4361.00
36_L40_M3.1861.00
43_K46_E2.6721.00
35_A38_R2.6391.00
45_G49_G2.3541.00
11_D15_R2.2961.00
8_F12_V2.2351.00
68_L72_A2.1651.00
34_A38_R2.0041.00
19_A23_D1.9511.00
34_A42_W1.8591.00
67_R70_L1.7461.00
31_E34_A1.6851.00
12_V15_R1.6431.00
45_G48_L1.6331.00
37_L42_W1.5871.00
27_V31_E1.5721.00
32_F35_A1.5241.00
33_G37_L1.4320.99
64_R68_L1.3880.99
9_K12_V1.3830.99
47_G55_R1.2460.98
7_A10_R1.2440.98
5_E9_K1.2290.98
8_F13_E1.2290.98
65_P68_L1.2090.98
8_F11_D1.1730.97
6_E10_R1.1580.97
20_T23_D1.1340.97
26_A62_E1.1160.96
48_L54_G1.0870.96
68_L74_P1.0850.96
37_L60_E1.0570.95
42_W49_G1.0220.94
44_E49_G1.0130.94
27_V35_A0.9420.91
11_D68_L0.9350.91
38_R44_E0.9340.91
49_G59_I0.9300.90
24_Y29_V0.9230.90
47_G54_G0.9070.89
27_V33_G0.9020.89
36_L67_R0.8800.88
23_D27_V0.8710.87
19_A63_R0.8400.85
55_R58_P0.8330.85
16_P20_T0.8180.84
24_Y28_P0.8170.84
28_P32_F0.8170.84
18_E21_L0.8110.83
9_K13_E0.7980.82
29_V35_A0.7950.82
4_E8_F0.7880.81
4_E7_A0.7780.81
32_F38_R0.7750.80
28_P38_R0.7700.80
5_E10_R0.7700.80
49_G58_P0.7630.79
66_A74_P0.7620.79
24_Y65_P0.7400.77
24_Y32_F0.7330.76
48_L55_R0.7260.76
43_K48_L0.7240.76
36_L39_G0.7210.75
42_W45_G0.7170.75
27_V38_R0.7170.75
26_A59_I0.7150.75
31_E38_R0.7040.73
29_V32_F0.7040.73
28_P31_E0.7030.73
13_E16_P0.6890.72
50_K53_K0.6870.72
9_K14_S0.6800.71
62_E75_K0.6750.70
63_R67_R0.6700.70
47_G58_P0.6620.69
63_R73_K0.6570.68
32_F39_G0.6540.68
34_A63_R0.6410.66
10_R15_R0.6350.66
59_I62_E0.6340.66
24_Y72_A0.6330.65
66_A70_L0.6320.65
31_E35_A0.6240.64
24_Y27_V0.6210.64
6_E14_S0.6190.64
32_F64_R0.6110.63
8_F18_E0.6110.63
25_E30_E0.6000.61
64_R72_A0.5960.61
6_E9_K0.5870.60
37_L41_G0.5820.59
45_G50_K0.5800.59
43_K59_I0.5740.58
47_G50_K0.5740.58
54_G58_P0.5560.56
22_E25_E0.5370.53
20_T27_V0.5360.53
4_E21_L0.5350.53
65_P72_A0.5280.52
62_E70_L0.5270.52
12_V22_E0.5240.51
13_E56_V0.5190.51
64_R67_R0.5170.50
30_E65_P0.5150.50
15_R51_N0.5120.50
20_T57_E0.5040.49
62_E68_L0.5030.48
10_R76_P0.5020.48
7_A22_E0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lx9A 1 0.8312 5.3 0.891 Contact Map
2k5lA 1 0.8831 5.1 0.892 Contact Map
2k4yA 1 0.9221 4.2 0.896 Contact Map
2k5iA 1 0.8701 4.1 0.897 Contact Map
2gcxA 1 0.8312 3.9 0.898 Contact Map
2k5fA 1 0.8701 3.5 0.901 Contact Map
3mhxA 1 0.8831 3 0.904 Contact Map
2h3jA 1 0.8442 2.9 0.904 Contact Map
4o5vA 2 0.961 2.9 0.904 Contact Map
2qq9A 2 0.8831 2.5 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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