GREMLIN Database
DUF3786 - Domain of unknown function (DUF3786)
PFAM: PF12654 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 176 (173)
Sequences: 6339 (4874)
Seq/√Len: 370.6
META: 0.929

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_K155_A3.9531.00
70_W135_L3.4241.00
101_D104_L3.4131.00
157_A166_L3.1641.00
120_G137_I2.8391.00
109_A124_V2.5861.00
125_V135_L2.5521.00
22_P27_D2.3811.00
115_E125_V2.2811.00
31_D34_G2.2481.00
87_H92_K2.2171.00
62_K159_D2.1701.00
77_P158_E2.1111.00
141_G147_A2.0261.00
117_L123_S1.8781.00
12_E20_T1.8201.00
128_A169_L1.8201.00
106_L110_E1.7981.00
117_L135_L1.7851.00
67_S155_A1.7551.00
121_D140_E1.7191.00
106_L116_P1.6881.00
102_P140_E1.6841.00
106_L122_A1.6741.00
14_D20_T1.6621.00
20_T27_D1.6541.00
88_K92_K1.6201.00
56_H165_D1.6101.00
4_E8_R1.6101.00
11_A21_L1.6081.00
68_G154_D1.5741.00
117_L125_V1.5411.00
106_L124_V1.5381.00
115_E127_P1.5231.00
164_E167_A1.4591.00
104_L107_E1.4181.00
2_P19_L1.4171.00
71_I76_L1.4051.00
92_K96_K1.3881.00
90_A151_I1.3811.00
107_E110_E1.3731.00
54_L129_L1.3691.00
23_F50_E1.3551.00
28_Y54_L1.3461.00
82_Y89_R1.3221.00
64_T159_D1.3051.00
136_L174_V1.3001.00
76_L157_A1.2731.00
127_P133_P1.2681.00
108_A111_K1.2561.00
95_A149_A1.2531.00
11_A19_L1.2511.00
14_D17_G1.2481.00
133_P156_S1.2321.00
126_F173_L1.2291.00
21_L28_Y1.2291.00
132_V157_A1.2131.00
103_E107_E1.2041.00
136_L173_L1.2021.00
24_L128_A1.2001.00
84_P88_K1.1851.00
167_A171_E1.1761.00
72_S83_F1.1711.00
102_P122_A1.1671.00
110_E124_V1.1661.00
72_S75_E1.1601.00
69_K75_E1.1561.00
26_R39_D1.1291.00
6_A19_L1.1281.00
21_L30_V1.1211.00
99_G147_A1.1081.00
125_V133_P1.1021.00
20_T29_R1.1001.00
53_L129_L1.0961.00
4_E7_R1.0901.00
109_A126_F1.0871.00
133_P154_D1.0861.00
23_F128_A1.0861.00
12_E27_D1.0821.00
5_V19_L1.0791.00
102_P106_L1.0761.00
85_A167_A1.0611.00
83_F87_H1.0561.00
74_R83_F1.0541.00
56_H162_P1.0391.00
66_L133_P1.0361.00
82_Y85_A1.0311.00
17_G29_R1.0271.00
162_P165_D1.0221.00
30_V37_I1.0191.00
76_L166_L1.0141.00
32_P35_G1.0121.00
19_L58_L1.0061.00
29_R40_G1.0021.00
99_G138_L0.9971.00
5_V8_R0.9951.00
73_F86_F0.9941.00
76_L163_T0.9911.00
134_L173_L0.9901.00
73_F167_A0.9901.00
131_R160_Y0.9821.00
29_R38_S0.9801.00
79_G163_T0.9651.00
120_G139_W0.9611.00
8_R63_G0.9561.00
161_L165_D0.9521.00
137_I152_L0.9511.00
107_E111_K0.9451.00
6_A13_Y0.9391.00
61_A160_Y0.9321.00
90_A93_P0.9311.00
142_D145_F0.9281.00
3_E15_G0.9221.00
110_E116_P0.9221.00
64_T156_S0.9161.00
106_L109_A0.9151.00
19_L32_P0.9101.00
65_P131_R0.9101.00
91_E150_N0.8971.00
13_Y16_D0.8941.00
49_W171_E0.8881.00
2_P13_Y0.8811.00
53_L168_V0.8701.00
73_F163_T0.8671.00
86_F170_G0.8611.00
15_G18_G0.8591.00
164_E168_V0.8581.00
85_A88_K0.8571.00
28_Y46_V0.8531.00
26_R41_D0.8441.00
86_F90_A0.8441.00
100_G141_G0.8411.00
60_N162_P0.8401.00
119_L137_I0.8311.00
22_P130_P0.8191.00
105_L124_V0.8171.00
128_A133_P0.8141.00
122_A140_E0.8111.00
2_P32_P0.8071.00
20_T40_G0.8051.00
31_D36_E0.8041.00
170_G173_L0.8021.00
98_F108_A0.7961.00
56_H164_E0.7911.00
158_E163_T0.7891.00
6_A11_A0.7871.00
70_W125_V0.7831.00
21_L54_L0.7801.00
27_D40_G0.7801.00
13_Y19_L0.7781.00
94_L149_A0.7771.00
46_V51_Q0.7691.00
119_L123_S0.7671.00
123_S137_I0.7641.00
57_Y131_R0.7601.00
66_L156_S0.7541.00
67_S156_S0.7531.00
78_G81_F0.7521.00
40_G43_G0.7491.00
153_F170_G0.7491.00
103_E106_L0.7471.00
99_G141_G0.7461.00
114_G126_F0.7421.00
168_V171_E0.7341.00
14_D18_G0.7321.00
167_A170_G0.7311.00
86_F153_F0.7201.00
9_L61_A0.7171.00
102_P105_L0.7161.00
170_G174_V0.7080.99
9_L58_L0.7070.99
100_G140_E0.7050.99
119_L135_L0.7000.99
30_V58_L0.6990.99
2_P5_V0.6990.99
165_D168_V0.6970.99
94_L174_V0.6960.99
85_A89_R0.6950.99
13_Y18_G0.6870.99
28_Y39_D0.6850.99
87_H91_E0.6820.99
22_P113_G0.6790.99
78_G163_T0.6770.99
67_S154_D0.6720.99
136_L151_I0.6720.99
63_G160_Y0.6680.99
116_P124_V0.6670.99
103_E140_E0.6660.99
63_G131_R0.6620.99
47_P50_E0.6620.99
3_E7_R0.6610.99
73_F85_A0.6600.99
171_E174_V0.6590.99
141_G145_F0.6590.99
50_E54_L0.6590.99
74_R80_A0.6540.99
93_P96_K0.6500.99
118_D123_S0.6490.99
28_Y37_I0.6490.99
81_F85_A0.6420.99
97_R104_L0.6380.99
108_A112_L0.6340.99
23_F54_L0.6320.99
168_V172_L0.6200.99
5_V9_L0.6140.99
98_F138_L0.6110.98
90_A167_A0.6110.98
99_G140_E0.6050.98
109_A113_G0.6040.98
23_F172_L0.6030.98
82_Y168_V0.6030.98
90_A174_V0.6020.98
109_A114_G0.5990.98
84_P87_H0.5960.98
81_F84_P0.5910.98
132_V169_L0.5890.98
48_P51_Q0.5880.98
77_P163_T0.5860.98
89_R165_D0.5820.98
86_F91_E0.5800.98
3_E13_Y0.5800.98
3_E6_A0.5790.98
162_P168_V0.5780.98
92_K95_A0.5760.98
56_H60_N0.5750.98
73_F82_Y0.5750.98
73_F90_A0.5720.98
149_A174_V0.5630.97
142_D146_P0.5580.97
60_N160_Y0.5580.97
86_F89_R0.5580.97
67_S159_D0.5580.97
10_G131_R0.5570.97
66_L154_D0.5560.97
145_F148_S0.5550.97
134_L153_F0.5520.97
6_A9_L0.5500.97
39_D42_G0.5450.97
74_R81_F0.5440.97
55_L58_L0.5440.97
134_L151_I0.5430.97
39_D44_E0.5340.96
50_E172_L0.5320.96
52_I56_H0.5300.96
82_Y167_A0.5280.96
165_D171_E0.5280.96
101_D105_L0.5260.96
31_D38_S0.5260.96
17_G31_D0.5250.96
93_P174_V0.5230.96
47_P172_L0.5210.96
120_G123_S0.5200.96
13_Y17_G0.5160.96
151_I170_G0.5140.96
9_L19_L0.5110.95
2_P6_A0.5090.95
53_L165_D0.5060.95
89_R171_E0.5060.95
157_A161_L0.5010.95
24_L173_L0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g6vB 1 0.3352 6.7 0.946 Contact Map
3kf8B 1 0.625 6.1 0.947 Contact Map
1ghhA 1 0.1591 5.7 0.947 Contact Map
1yo5C 1 0.2955 3.3 0.953 Contact Map
4g32A 1 0.9318 3 0.954 Contact Map
1wwxA 1 0.3693 3 0.954 Contact Map
2kz3A 1 0.2784 3 0.954 Contact Map
1fi2A 5 0.5909 2.9 0.955 Contact Map
2uvaG 3 0.8409 2.7 0.955 Contact Map
3zenD 6 0.8864 2.7 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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