GREMLIN Database
CotJB - CotJB protein
PFAM: PF12652 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (75)
Sequences: 2997 (2340)
Seq/√Len: 270.1
META: 0.803

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_D41_R2.8501.00
41_R45_K2.5531.00
18_N57_N2.2001.00
13_A37_Y2.1831.00
5_K9_A2.1001.00
15_V18_N2.0631.00
47_E51_K2.0091.00
49_E59_G1.9351.00
17_L33_L1.8441.00
71_D76_E1.8191.00
5_K8_Q1.8041.00
7_I44_L1.7771.00
40_E43_E1.6771.00
46_K50_K1.6571.00
10_L37_Y1.5261.00
38_A42_K1.5251.00
48_Y53_G1.4571.00
20_Y27_D1.4491.00
42_K46_K1.4281.00
14_L41_R1.4261.00
33_L36_E1.4251.00
31_L35_N1.4061.00
14_L37_Y1.3561.00
10_L44_L1.3521.00
2_E6_E1.2751.00
67_Q70_D1.2711.00
7_I45_K1.2661.00
27_D30_A1.2621.00
39_K43_E1.2491.00
6_E40_E1.2481.00
14_L38_A1.2321.00
40_E44_L1.2151.00
45_K49_E1.2031.00
7_I41_R1.1941.00
29_E32_A1.1581.00
56_T60_V1.1401.00
36_E40_E1.1261.00
28_Q32_A1.1231.00
6_E9_A1.1181.00
15_V19_L1.0781.00
65_P70_D1.0491.00
31_L66_W1.0331.00
43_E47_E1.0241.00
4_L8_Q1.0191.00
11_D45_K1.0051.00
34_Y38_A0.9661.00
6_E44_L0.9311.00
69_I73_W0.9161.00
47_E50_K0.9111.00
66_W69_I0.8791.00
54_P67_Q0.8641.00
18_N34_Y0.8571.00
33_L37_Y0.8481.00
28_Q64_D0.8280.99
11_D15_V0.8220.99
12_F16_E0.8150.99
62_S65_P0.8040.99
8_Q11_D0.7890.99
37_Y40_E0.7830.99
6_E47_E0.7580.99
13_A16_E0.7560.99
36_E39_K0.7450.99
6_E10_L0.7400.99
7_I10_L0.7390.99
10_L40_E0.7360.99
10_L41_R0.7240.99
13_A33_L0.7050.98
35_N38_A0.7030.98
18_N22_D0.7030.98
14_L57_N0.6950.98
3_L47_E0.6800.98
4_L55_L0.6780.98
13_A17_L0.6740.98
53_G73_W0.6720.98
20_Y24_H0.6660.98
3_L44_L0.6620.97
3_L7_I0.6600.97
34_Y57_N0.6590.97
38_A60_V0.6580.97
18_N68_W0.6580.97
7_I55_L0.6530.97
21_L66_W0.6530.97
15_V58_F0.6520.97
22_D68_W0.6500.97
45_K56_T0.6180.96
25_P69_I0.6180.96
44_L47_E0.6030.96
20_Y30_A0.6000.95
35_N61_S0.5980.95
23_T27_D0.5910.95
35_N59_G0.5800.95
3_L48_Y0.5760.94
4_L48_Y0.5680.94
48_Y52_Y0.5660.94
49_E53_G0.5660.94
11_D14_L0.5660.94
20_Y33_L0.5630.94
60_V63_S0.5630.94
65_P69_I0.5600.93
32_A36_E0.5570.93
10_L17_L0.5520.93
33_L76_E0.5500.93
46_K49_E0.5410.92
7_I48_Y0.5400.92
21_L34_Y0.5280.91
59_G62_S0.5270.91
73_W76_E0.5260.91
18_N58_F0.5210.91
8_Q16_E0.5190.91
12_F20_Y0.5020.89
7_I11_D0.5010.89
19_L76_E0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rczB 1 0.6316 27.4 0.885 Contact Map
2mnuB 1 0.25 27.3 0.885 Contact Map
1wwzA 2 0.7368 16.5 0.897 Contact Map
2ayvA 1 0.5789 16.1 0.897 Contact Map
2wpxA 1 0.7237 16 0.897 Contact Map
2gjdA 4 0.6316 14.4 0.899 Contact Map
1zdnA 2 0.5789 14.2 0.899 Contact Map
2fbnA 2 0.5921 14.1 0.899 Contact Map
3bzhA 2 0.5921 13.9 0.9 Contact Map
2j8mA 2 0.8158 13.6 0.9 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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