GREMLIN Database
DUF3784 - Domain of unknown function (DUF3784)
PFAM: PF12650 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 96 (93)
Sequences: 2787 (2420)
Seq/√Len: 250.9
META: 0.822

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_K35_E2.6441.00
4_G54_G2.4401.00
20_A43_C2.3751.00
38_D41_K2.3471.00
11_G51_L2.2721.00
12_I17_G2.2441.00
37_Y42_L2.2411.00
8_I54_G2.2201.00
77_L81_I2.1321.00
15_L48_K2.1151.00
24_A27_N2.0511.00
30_S33_E1.9181.00
87_I91_K1.7731.00
24_A28_T1.7511.00
21_F34_K1.7191.00
72_I76_I1.7191.00
26_Y39_I1.7101.00
2_I6_L1.6981.00
4_G58_L1.6821.00
9_I13_L1.6251.00
74_A78_F1.5381.00
47_G51_L1.5301.00
56_I60_G1.5191.00
13_L19_G1.4731.00
33_E36_K1.4691.00
75_I78_F1.4581.00
43_C47_G1.3981.00
32_E35_E1.3391.00
74_A77_L1.3111.00
26_Y34_K1.2851.00
11_G54_G1.2781.00
25_G28_T1.2651.00
85_V89_I1.2311.00
63_L70_W1.2181.00
87_I90_N1.1941.00
90_N93_N1.1751.00
75_I79_I1.1661.00
3_I7_F1.1481.00
11_G15_L1.1451.00
15_L51_L1.1351.00
67_L70_W1.1311.00
63_L68_S1.1251.00
31_K34_K1.1141.00
84_G88_Y1.0971.00
23_I46_M1.0911.00
78_F81_I1.0751.00
91_K94_R1.0451.00
80_V84_G1.0351.00
39_I43_C1.0341.00
78_F82_L1.0241.00
12_I16_K0.9951.00
14_I43_C0.9891.00
20_A39_I0.9691.00
23_I42_L0.9651.00
81_I85_V0.9581.00
72_I75_I0.9561.00
16_K40_K0.9551.00
49_F53_L0.9471.00
64_S67_L0.9441.00
64_S69_N0.9371.00
52_I56_I0.9211.00
17_G47_G0.9191.00
88_Y91_K0.9151.00
51_L55_I0.8971.00
71_L75_I0.8711.00
14_I20_A0.8620.99
26_Y29_M0.8470.99
64_S70_W0.8280.99
14_I46_M0.8240.99
48_K51_L0.8090.99
86_V90_N0.8010.99
42_L46_M0.8010.99
23_I43_C0.8000.99
48_K52_I0.7800.99
18_K43_C0.7690.99
58_L61_G0.7670.99
82_L85_V0.7610.99
6_L54_G0.7560.99
81_I84_G0.7560.99
88_Y92_G0.7490.99
90_N94_R0.7430.98
4_G11_G0.7360.98
17_G20_A0.7320.98
11_G14_I0.7280.98
82_L86_V0.7240.98
20_A34_K0.7190.98
89_I92_G0.6970.98
37_Y41_K0.6940.98
41_K45_F0.6850.97
16_K48_K0.6790.97
64_S68_S0.6720.97
16_K20_A0.6670.97
53_L61_G0.6610.97
46_M50_L0.6610.97
77_L88_Y0.6610.97
81_I88_Y0.6580.97
8_I51_L0.6540.97
73_I79_I0.6480.96
84_G87_I0.6470.96
10_L13_L0.6440.96
74_A85_V0.6420.96
76_I81_I0.6390.96
85_V90_N0.6380.96
85_V88_Y0.6340.96
15_L44_R0.6260.96
29_M37_Y0.6250.96
45_F48_K0.6190.95
86_V92_G0.6180.95
37_Y43_C0.6150.95
72_I83_I0.6090.95
52_I55_I0.6000.94
7_F46_M0.5910.94
49_F85_V0.5860.94
81_I86_V0.5830.94
29_M33_E0.5790.93
49_F88_Y0.5740.93
71_L78_F0.5730.93
65_L69_N0.5720.93
88_Y94_R0.5710.93
4_G61_G0.5590.92
84_G92_G0.5530.92
57_L60_G0.5510.92
77_L80_V0.5420.91
15_L47_G0.5420.91
15_L19_G0.5370.90
81_I87_I0.5350.90
4_G57_L0.5330.90
4_G7_F0.5230.89
46_M49_F0.5230.89
55_I62_L0.5180.89
7_F53_L0.5170.89
15_L50_L0.5170.89
26_Y43_C0.5160.89
29_M47_G0.5140.88
27_N34_K0.5120.88
63_L67_L0.5110.88
57_L77_L0.5090.88
14_I50_L0.5090.88
9_I36_K0.5010.87
21_F24_A0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pjzA 2 0.625 14.5 0.852 Contact Map
2akhX 1 0.7188 9.2 0.864 Contact Map
2xq2A 2 0.8542 8.8 0.866 Contact Map
3j45G 1 0.6667 7.9 0.869 Contact Map
3dinE 1 0.6771 6.9 0.872 Contact Map
2mkvA 1 0.375 6.5 0.873 Contact Map
4a2nB 1 0.9583 6.3 0.875 Contact Map
2wjnH 1 0.4062 6.1 0.875 Contact Map
4ev6A 3 0.9479 5.6 0.878 Contact Map
2mofA 1 0.2708 5.4 0.878 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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