GREMLIN Database
TcpE - TcpE family
PFAM: PF12648 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 103 (97)
Sequences: 833 (611)
Seq/√Len: 62.1
META: 0.701

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_F67_A4.0511.00
39_V62_I3.0831.00
31_Y70_L2.6461.00
26_L30_G2.5321.00
59_Y63_P2.3971.00
35_I66_L2.0831.00
14_K17_D1.9701.00
1_S31_Y1.8671.00
9_E13_Y1.8391.00
25_P28_Q1.8101.00
6_F13_Y1.7640.99
87_Q90_Y1.7290.99
53_L61_V1.7040.99
67_A71_T1.6710.99
35_I67_A1.6540.99
29_I64_G1.5920.99
82_R85_K1.5890.99
94_P97_W1.5890.99
33_V37_L1.5740.99
83_F87_Q1.5680.99
5_I13_Y1.5200.98
37_L40_L1.4850.98
26_L70_L1.4700.98
13_Y23_P1.4330.98
41_L62_I1.4040.97
28_Q67_A1.4010.97
85_K91_L1.3600.97
9_E86_S1.3600.97
78_K83_F1.3280.96
40_L88_L1.3260.96
10_K78_K1.3170.96
69_L75_P1.2950.96
93_R97_W1.2320.94
56_L88_L1.2250.94
1_S8_I1.2220.94
91_L95_K1.2150.94
60_V69_L1.2140.94
24_V40_L1.2110.94
9_E46_P1.2100.94
32_F59_Y1.2020.94
85_K89_R1.1490.92
33_V36_L1.1380.92
15_I33_V1.1340.92
30_G82_R1.1280.91
2_Y7_R1.1160.91
88_L92_F1.0950.90
78_K90_Y1.0750.89
64_G68_W1.0720.89
32_F64_G1.0450.88
42_L48_L1.0440.88
10_K86_S1.0240.87
3_T86_S0.9820.84
41_L76_D0.9590.83
35_I89_R0.9530.83
4_R72_R0.9530.83
1_S6_F0.9510.82
84_L96_L0.9340.81
28_Q68_W0.9320.81
50_N53_L0.9150.80
69_L73_P0.9080.79
83_F86_S0.8880.78
87_Q91_L0.8840.78
6_F27_R0.8840.78
27_R46_P0.8830.77
11_R25_P0.8690.76
4_R16_G0.8690.76
3_T68_W0.8680.76
46_P64_G0.8650.76
40_L52_V0.8600.76
62_I73_P0.8380.74
70_L74_K0.8360.74
6_F80_P0.8360.74
12_I26_L0.8320.73
65_A69_L0.8310.73
49_I52_V0.8310.73
22_F25_P0.7990.70
23_P77_G0.7980.70
13_Y20_L0.7950.70
30_G39_V0.7950.70
4_R9_E0.7850.69
72_R75_P0.7820.68
15_I85_K0.7790.68
35_I39_V0.7650.67
8_I11_R0.7610.66
31_Y76_D0.7590.66
18_F23_P0.7410.64
43_L50_N0.7410.64
33_V66_L0.7360.64
48_L60_V0.7200.62
40_L49_I0.7150.62
41_L45_L0.7140.61
34_A42_L0.7120.61
44_R48_L0.6980.60
24_V39_V0.6960.59
7_R21_P0.6940.59
50_N61_V0.6940.59
50_N54_P0.6910.59
57_L81_H0.6900.59
24_V29_I0.6830.58
79_R82_R0.6830.58
2_Y42_L0.6820.58
19_R71_T0.6800.58
57_L84_L0.6800.58
31_Y58_L0.6780.57
39_V76_D0.6730.57
23_P71_T0.6710.57
32_F80_P0.6660.56
6_F86_S0.6630.56
7_R29_I0.6530.55
8_I75_P0.6350.53
10_K16_G0.6330.52
29_I70_L0.6320.52
41_L50_N0.6260.52
37_L41_L0.6240.51
34_A53_L0.6200.51
7_R82_R0.6180.51
5_I8_I0.6160.50
26_L89_R0.6080.50
56_L65_A0.6040.49
57_L77_G0.5910.48
18_F65_A0.5900.47
31_Y67_A0.5890.47
52_V60_V0.5870.47
5_I74_K0.5850.47
61_V64_G0.5760.46
89_R93_R0.5760.46
13_Y71_T0.5710.45
40_L59_Y0.5680.45
9_E27_R0.5580.44
49_I74_K0.5570.44
23_P30_G0.5550.43
80_P84_L0.5540.43
31_Y84_L0.5480.43
9_E74_K0.5450.42
35_I49_I0.5410.42
82_R86_S0.5390.42
2_Y68_W0.5290.41
36_L39_V0.5290.41
64_G74_K0.5220.40
92_F97_W0.5190.39
5_I9_E0.5160.39
1_S28_Q0.5150.39
17_D28_Q0.5130.39
1_S10_K0.5100.39
36_L58_L0.5020.38
37_L92_F0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j01B 1 0.7573 2.4 0.919 Contact Map
4hfiA 3 0.3495 2 0.922 Contact Map
2mbgA 1 0.4951 2 0.923 Contact Map
4w252 1 0.2718 1.8 0.924 Contact Map
4b03D 5 0.5631 1.7 0.926 Contact Map
2ovjA 1 0.3786 1.6 0.927 Contact Map
1rh5B 1 0.233 1.3 0.931 Contact Map
3mp7B 1 0.233 1.2 0.933 Contact Map
1tx4A 1 0.4563 1 0.935 Contact Map
4rb5J 1 0.2913 1 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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