GREMLIN Database
DUF3783 - Domain of unknown function (DUF3783)
PFAM: PF12646 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 56 (56)
Sequences: 1985 (1505)
Seq/√Len: 201.1
META: 0.826

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_S33_L3.5491.00
41_T44_D2.8571.00
9_S12_E2.4431.00
2_M42_L2.3911.00
29_L49_L2.2761.00
33_L38_E2.1411.00
48_E51_E1.8031.00
44_D48_E1.7841.00
2_M46_L1.7761.00
1_E27_I1.5901.00
28_P53_H1.5461.00
50_A54_E1.4841.00
14_D17_L1.4621.00
40_W52_E1.3761.00
14_D18_D1.3571.00
27_I30_K1.2291.00
35_P38_E1.2161.00
19_A23_A1.1691.00
53_H56_M1.1561.00
11_E15_A1.1291.00
37_N45_L1.1281.00
20_L26_P1.1231.00
20_L30_K1.1101.00
50_A53_H1.0871.00
42_L46_L1.0611.00
17_L30_K1.0201.00
12_E15_A1.0111.00
34_T52_E1.0031.00
4_I31_A0.9921.00
36_T40_W0.9811.00
47_E54_E0.9741.00
51_E55_A0.9600.99
52_E56_M0.9590.99
20_L25_L0.9340.99
31_A49_L0.9290.99
10_E14_D0.9190.99
13_L17_L0.9060.99
47_E51_E0.9010.99
15_A19_A0.8960.99
8_F12_E0.8790.99
4_I42_L0.8760.99
16_L20_L0.8750.99
11_E43_K0.8730.99
51_E54_E0.8700.99
8_F13_L0.8510.99
4_I49_L0.8280.98
36_T39_N0.8160.98
8_F16_L0.7840.98
5_F8_F0.7800.98
31_A37_N0.7780.98
34_T40_W0.7690.97
19_A22_K0.7150.96
18_D22_K0.7150.96
2_M49_L0.6970.95
21_R31_A0.6820.95
7_G39_N0.6740.94
29_L46_L0.6610.94
11_E39_N0.6450.93
4_I40_W0.6390.93
17_L27_I0.6380.93
37_N49_L0.6330.92
10_E13_L0.6170.91
15_A18_D0.6160.91
37_N40_W0.6050.91
1_E26_P0.5930.90
13_L32_V0.5910.90
14_D21_R0.5890.90
2_M29_L0.5750.88
43_K47_E0.5690.88
48_E56_M0.5670.88
46_L50_A0.5650.87
5_F13_L0.5590.87
43_K46_L0.5570.87
5_F30_K0.5480.86
10_E32_V0.5380.85
10_E22_K0.5250.83
19_A54_E0.5240.83
40_W49_L0.5200.83
10_E46_L0.5130.82
25_L30_K0.5110.82
49_L52_E0.5050.81
3_L37_N0.5030.81
4_I45_L0.5010.81
49_L53_H0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cxjA 3 0.6429 18 0.83 Contact Map
4ioyX 1 0.8393 16.3 0.833 Contact Map
2fe3A 2 0.8393 13.9 0.838 Contact Map
4n6cA 1 0.8929 13.3 0.84 Contact Map
3jszA 1 0.9821 13.3 0.84 Contact Map
2nrtA 1 0.9821 11.7 0.844 Contact Map
2nx9A 2 0.7679 10.1 0.848 Contact Map
3hp4A 1 1 9.5 0.85 Contact Map
1uw4B 1 1 9.4 0.85 Contact Map
2nsfA 1 0.7857 9.1 0.851 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0043 seconds.