GREMLIN Database
DUF3782 - Protein of unknown function (DUF3782)
PFAM: PF12644 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 64 (58)
Sequences: 645 (497)
Seq/√Len: 65.2
META: 0.865

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_F57_G2.8031.00
19_E22_E2.5091.00
55_L58_I2.5021.00
10_I13_L2.3141.00
25_T28_Q2.1651.00
5_K8_E2.1371.00
15_E18_K1.9161.00
9_E14_K1.8671.00
28_Q32_L1.7511.00
38_A41_A1.6210.99
13_L17_L1.6130.99
14_K17_L1.5950.99
41_A52_R1.5680.99
54_G57_G1.5390.99
16_E21_R1.5170.99
15_E19_E1.4660.98
24_L28_Q1.3810.98
39_L52_R1.3450.97
6_L10_I1.3310.97
34_R45_I1.2490.96
46_M54_G1.2400.95
44_G52_R1.1720.94
10_I14_K1.1530.93
40_G44_G1.1380.93
9_E12_A1.1090.92
53_E56_R1.0850.91
18_K22_E1.0760.90
8_E11_E1.0660.90
40_G48_E1.0480.89
9_E13_L0.9940.87
26_K30_K0.9750.85
28_Q33_E0.9540.84
24_L35_Y0.9500.84
12_A15_E0.9470.84
24_L27_E0.9270.82
50_A53_E0.9230.82
37_D50_A0.9080.81
34_R37_D0.8980.80
43_W52_R0.8950.80
39_L44_G0.8860.80
36_I48_E0.8790.79
48_E52_R0.8730.78
45_I58_I0.8460.76
17_L23_R0.8100.73
27_E32_L0.7840.71
40_G52_R0.7830.71
36_I60_E0.7640.69
43_W48_E0.7620.68
52_R55_L0.7470.67
40_G50_A0.7390.66
35_Y46_M0.7250.65
42_R48_E0.7220.64
17_L21_R0.7200.64
33_E37_D0.7190.64
39_L43_W0.7150.64
13_L20_L0.7060.63
39_L45_I0.6990.62
46_M49_E0.6930.61
40_G43_W0.6870.60
25_T29_F0.6710.59
39_L42_R0.6670.58
42_R45_I0.6520.56
32_L35_Y0.6410.55
42_R52_R0.6140.52
55_L59_L0.6100.52
57_G60_E0.6090.51
32_L37_D0.6080.51
29_F32_L0.6080.51
47_S54_G0.6030.51
20_L23_R0.6010.51
11_E14_K0.5990.50
4_A8_E0.5900.49
7_Q10_I0.5840.49
43_W58_I0.5540.45
27_E61_D0.5520.45
56_R60_E0.5510.45
9_E19_E0.5490.44
30_K47_S0.5450.44
38_A57_G0.5450.44
27_E30_K0.5330.43
45_I49_E0.5300.42
16_E19_E0.5250.42
13_L21_R0.5240.42
38_A44_G0.5130.40
4_A12_A0.5100.40
17_L20_L0.5090.40
24_L54_G0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vlcE 1 0.5469 10.6 0.833 Contact Map
3b2eE 1 0.5469 8.7 0.839 Contact Map
3sjbC 1 0.5312 8.4 0.84 Contact Map
3itfA 2 0.7344 7.3 0.844 Contact Map
4wwfA 2 0.6406 6.7 0.847 Contact Map
2wujA 2 0.2969 5.4 0.853 Contact Map
3a7pA 2 0.6562 5.1 0.855 Contact Map
3o39A 2 0.5938 4.9 0.856 Contact Map
1h67A 1 0.5781 4.5 0.858 Contact Map
3sjaC 1 0.4688 4.5 0.858 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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